2JJ8
Structural Studies of Nucleoside Analog and Feedback Inhibitor Binding to Drosophila Melanogaster Multisubstrate Deoxyribonucleoside Kinase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004136 | molecular_function | deoxyadenosine kinase activity |
| A | 0004137 | molecular_function | deoxycytidine kinase activity |
| A | 0004138 | molecular_function | deoxyguanosine kinase activity |
| A | 0004797 | molecular_function | thymidine kinase activity |
| A | 0004849 | molecular_function | uridine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006170 | biological_process | dAMP biosynthetic process |
| A | 0006222 | biological_process | UMP biosynthetic process |
| A | 0009157 | biological_process | deoxyribonucleoside monophosphate biosynthetic process |
| A | 0009224 | biological_process | CMP biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0019136 | molecular_function | deoxynucleoside kinase activity |
| A | 0043174 | biological_process | nucleoside salvage |
| A | 0043771 | molecular_function | cytidine kinase activity |
| A | 1901293 | biological_process | nucleoside phosphate biosynthetic process |
| B | 0004136 | molecular_function | deoxyadenosine kinase activity |
| B | 0004137 | molecular_function | deoxycytidine kinase activity |
| B | 0004138 | molecular_function | deoxyguanosine kinase activity |
| B | 0004797 | molecular_function | thymidine kinase activity |
| B | 0004849 | molecular_function | uridine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0006170 | biological_process | dAMP biosynthetic process |
| B | 0006222 | biological_process | UMP biosynthetic process |
| B | 0009157 | biological_process | deoxyribonucleoside monophosphate biosynthetic process |
| B | 0009224 | biological_process | CMP biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0019136 | molecular_function | deoxynucleoside kinase activity |
| B | 0043174 | biological_process | nucleoside salvage |
| B | 0043771 | molecular_function | cytidine kinase activity |
| B | 1901293 | biological_process | nucleoside phosphate biosynthetic process |
| C | 0004136 | molecular_function | deoxyadenosine kinase activity |
| C | 0004137 | molecular_function | deoxycytidine kinase activity |
| C | 0004138 | molecular_function | deoxyguanosine kinase activity |
| C | 0004797 | molecular_function | thymidine kinase activity |
| C | 0004849 | molecular_function | uridine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| C | 0006170 | biological_process | dAMP biosynthetic process |
| C | 0006222 | biological_process | UMP biosynthetic process |
| C | 0009157 | biological_process | deoxyribonucleoside monophosphate biosynthetic process |
| C | 0009224 | biological_process | CMP biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0019136 | molecular_function | deoxynucleoside kinase activity |
| C | 0043174 | biological_process | nucleoside salvage |
| C | 0043771 | molecular_function | cytidine kinase activity |
| C | 1901293 | biological_process | nucleoside phosphate biosynthetic process |
| D | 0004136 | molecular_function | deoxyadenosine kinase activity |
| D | 0004137 | molecular_function | deoxycytidine kinase activity |
| D | 0004138 | molecular_function | deoxyguanosine kinase activity |
| D | 0004797 | molecular_function | thymidine kinase activity |
| D | 0004849 | molecular_function | uridine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| D | 0006170 | biological_process | dAMP biosynthetic process |
| D | 0006222 | biological_process | UMP biosynthetic process |
| D | 0009157 | biological_process | deoxyribonucleoside monophosphate biosynthetic process |
| D | 0009224 | biological_process | CMP biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0019136 | molecular_function | deoxynucleoside kinase activity |
| D | 0043174 | biological_process | nucleoside salvage |
| D | 0043771 | molecular_function | cytidine kinase activity |
| D | 1901293 | biological_process | nucleoside phosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1209 |
| Chain | Residue |
| A | ILE29 |
| A | LYS33 |
| A | GLU52 |
| A | ARG105 |
| A | SO41210 |
| A | AZZ1211 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1210 |
| Chain | Residue |
| A | LYS33 |
| A | THR34 |
| A | SO41209 |
| A | GLY30 |
| A | SER31 |
| A | GLY32 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE AZZ A 1211 |
| Chain | Residue |
| A | GLU52 |
| A | TRP57 |
| A | PHE80 |
| A | GLN81 |
| A | VAL84 |
| A | ARG105 |
| A | ALA110 |
| A | PHE114 |
| A | SO41209 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1209 |
| Chain | Residue |
| B | ASN28 |
| B | GLY30 |
| B | SER31 |
| B | GLY32 |
| B | LYS33 |
| B | THR34 |
| B | SO41210 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1210 |
| Chain | Residue |
| B | ILE29 |
| B | LYS33 |
| B | GLU52 |
| B | ARG105 |
| B | SO41209 |
| B | AZZ1211 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE AZZ B 1211 |
| Chain | Residue |
| B | GLU52 |
| B | TRP57 |
| B | TYR70 |
| B | PHE80 |
| B | GLN81 |
| B | VAL84 |
| B | ARG105 |
| B | ALA110 |
| B | PHE114 |
| B | SO41210 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1209 |
| Chain | Residue |
| C | GLY30 |
| C | SER31 |
| C | GLY32 |
| C | LYS33 |
| C | THR34 |
| C | SO41210 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1210 |
| Chain | Residue |
| C | ILE29 |
| C | LYS33 |
| C | GLU52 |
| C | ARG105 |
| C | SO41209 |
| C | AZZ1211 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE AZZ C 1211 |
| Chain | Residue |
| C | GLU52 |
| C | TRP57 |
| C | PHE80 |
| C | GLN81 |
| C | ARG105 |
| C | ALA110 |
| C | PHE114 |
| C | MET118 |
| C | SO41210 |
| site_id | BC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1209 |
| Chain | Residue |
| D | ASN28 |
| D | GLY30 |
| D | SER31 |
| D | GLY32 |
| D | LYS33 |
| D | THR34 |
| D | GLU104 |
| D | ARG167 |
| D | SO41210 |
| D | HOH2015 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1210 |
| Chain | Residue |
| D | ILE29 |
| D | LYS33 |
| D | GLU52 |
| D | ARG105 |
| D | SO41209 |
| D | AZZ1211 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE AZZ D 1211 |
| Chain | Residue |
| D | GLU52 |
| D | TRP57 |
| D | PHE80 |
| D | GLN81 |
| D | VAL84 |
| D | ARG105 |
| D | ALA110 |
| D | PHE114 |
| D | SO41210 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1kim |
| Chain | Residue | Details |
| A | GLY30 | |
| A | GLU52 | |
| A | ARG105 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1kim |
| Chain | Residue | Details |
| B | GLY30 | |
| B | GLU52 | |
| B | ARG105 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1kim |
| Chain | Residue | Details |
| C | GLY30 | |
| C | GLU52 | |
| C | ARG105 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1kim |
| Chain | Residue | Details |
| D | GLY30 | |
| D | GLU52 | |
| D | ARG105 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kim |
| Chain | Residue | Details |
| A | GLU52 | |
| A | ARG105 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kim |
| Chain | Residue | Details |
| B | GLU52 | |
| B | ARG105 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kim |
| Chain | Residue | Details |
| C | GLU52 | |
| C | ARG105 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kim |
| Chain | Residue | Details |
| D | GLU52 | |
| D | ARG105 |
