Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2JG7

Crystal structure of Seabream Antiquitin and Elucidation of its substrate specificity

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
A	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0000166	molecular_function	nucleotide binding
B	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
B	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0000166	molecular_function	nucleotide binding
C	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
C	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0000166	molecular_function	nucleotide binding
D	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
D	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity
D	0005634	cellular_component	nucleus
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0000166	molecular_function	nucleotide binding
E	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
E	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity
E	0005634	cellular_component	nucleus
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0000166	molecular_function	nucleotide binding
F	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
F	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity
F	0005634	cellular_component	nucleus
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G	0000166	molecular_function	nucleotide binding
G	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
G	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity
G	0005634	cellular_component	nucleus
G	0005739	cellular_component	mitochondrion
G	0005829	cellular_component	cytosol
G	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
G	0016491	molecular_function	oxidoreductase activity
G	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H	0000166	molecular_function	nucleotide binding
H	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
H	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity
H	0005634	cellular_component	nucleus
H	0005739	cellular_component	mitochondrion
H	0005829	cellular_component	cytosol
H	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
H	0016491	molecular_function	oxidoreductase activity
H	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAD A1510

Chain	Residue
A	ILE162
A	GLY229
A	THR230
A	PHE243
A	THR244
A	GLY245
A	SER246
A	VAL249
A	MET252
A	VAL253
A	GLU267
A	THR163
A	LEU268
A	GLY269
A	CYS301
A	GLU398
A	PHE400
A	PHE467
A	ALA164
A	PHE165
A	ASN166
A	LYS189
A	ALA191
A	PRO192
A	ALA226

site_id	AC2
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAD B1510

Chain	Residue
B	ILE162
B	THR163
B	ALA164
B	PHE165
B	ASN166
B	LYS189
B	ALA191
B	PRO192
B	ALA226
B	GLY229
B	THR230
B	PHE243
B	THR244
B	GLY245
B	SER246
B	VAL249
B	MET252
B	VAL253
B	GLU267
B	LEU268
B	GLY269
B	CYS301
B	GLU398
B	PHE400
B	PHE467

site_id	AC3
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAD C1510

Chain	Residue
C	ILE162
C	THR163
C	ALA164
C	PHE165
C	ASN166
C	LYS189
C	ALA191
C	PRO192
C	ALA226
C	GLY229
C	THR230
C	PHE243
C	THR244
C	GLY245
C	SER246
C	VAL249
C	MET252
C	VAL253
C	GLU267
C	LEU268
C	GLY269
C	CYS301
C	GLU398
C	PHE400
C	PHE467

site_id	AC4
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAD D1510

Chain	Residue
D	PHE467
D	ILE162
D	THR163
D	ALA164
D	PHE165
D	ASN166
D	LYS189
D	ALA191
D	PRO192
D	ALA226
D	GLY229
D	THR230
D	PHE243
D	THR244
D	GLY245
D	SER246
D	VAL249
D	MET252
D	VAL253
D	GLU267
D	LEU268
D	GLY269
D	CYS301
D	GLU398
D	PHE400

site_id	AC5
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAD E1510

Chain	Residue
E	ILE162
E	THR163
E	ALA164
E	PHE165
E	ASN166
E	LYS189
E	ALA191
E	PRO192
E	ALA226
E	GLY229
E	THR230
E	PHE243
E	THR244
E	GLY245
E	SER246
E	VAL249
E	MET252
E	VAL253
E	GLU267
E	LEU268
E	GLY269
E	CYS301
E	GLU398
E	PHE400
E	PHE467

site_id	AC6
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAD F1510

Chain	Residue
F	ILE162
F	THR163
F	ALA164
F	PHE165
F	ASN166
F	LYS189
F	ALA191
F	PRO192
F	ALA226
F	GLY229
F	THR230
F	PHE243
F	THR244
F	GLY245
F	SER246
F	VAL249
F	MET252
F	VAL253
F	GLU267
F	LEU268
F	GLY269
F	CYS301
F	GLU398
F	PHE400
F	PHE467
F	HOH2021

site_id	AC7
Number of Residues	28
Details	BINDING SITE FOR RESIDUE NAD G1510

Chain	Residue
G	ILE162
G	THR163
G	ALA164
G	PHE165
G	ASN166
G	LYS189
G	ALA191
G	PRO192
G	ALA226
G	GLY229
G	THR230
G	PHE243
G	THR244
G	GLY245
G	SER246
G	VAL249
G	MET252
G	VAL253
G	GLU267
G	LEU268
G	GLY269
G	CYS301
G	GLU398
G	PHE400
G	PHE467
G	HOH2015
G	HOH2030
G	HOH2031

site_id	AC8
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAD H1510

Chain	Residue
H	ILE162
H	THR163
H	ALA164
H	PHE165
H	ASN166
H	LYS189
H	ALA191
H	PRO192
H	ALA226
H	GLY229
H	THR230
H	PHE243
H	THR244
H	GLY245
H	SER246
H	VAL249
H	MET252
H	VAL253
H	GLU267
H	LEU268
H	GLY269
H	CYS301
H	GLU398
H	PHE400
H	PHE467
H	HOH2014

Functional Information from PROSITE/UniProt

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGNNA

Chain	Residue	Details
A	LEU266-ALA273

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
A	ASN166
A	CYS301
A	GLU267

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
B	ASN166
B	CYS301
B	GLU267

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
C	ASN166
C	CYS301
C	GLU267

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
D	ASN166
D	CYS301
D	GLU267

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
E	ASN166
E	CYS301
E	GLU267

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
F	ASN166
F	CYS301
F	GLU267

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
G	ASN166
G	CYS301
G	GLU267

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
H	ASN166
H	CYS301
H	GLU267

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)