Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 1100 |
| Chain | Residue |
| A | TRP42 |
| A | PRO44 |
| A | GLU65 |
| A | GLY68 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 1101 |
| Chain | Residue |
| A | GLU21 |
| A | VAL82 |
| A | ASN83 |
| A | HOH2059 |
| A | HOH2061 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 1102 |
| Chain | Residue |
| A | PHE99 |
| A | HOH2201 |
| A | HOH2202 |
| A | HOH2203 |
| A | HOH2204 |
| B | PHE53 |
| B | LYS55 |
| B | HIS69 |
| B | ACT1100 |
| B | SO41103 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1103 |
| Chain | Residue |
| A | THR12 |
| A | LYS41 |
| A | TRP42 |
| A | HOH2032 |
| A | HOH2033 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GOL A 1104 |
| Chain | Residue |
| A | GLN2 |
| A | HOH2205 |
| A | HOH2206 |
| A | HOH2207 |
| A | HOH2208 |
| A | HOH2209 |
| A | HOH2210 |
| A | HOH2211 |
| A | HOH2212 |
| B | PRO44 |
| B | VAL56 |
| B | ARG57 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1105 |
| Chain | Residue |
| A | PRO1 |
| A | ASN37 |
| A | ARG57 |
| A | HIS69 |
| A | SO41109 |
| A | HOH2213 |
| A | HOH2214 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1109 |
| Chain | Residue |
| A | PRO1 |
| A | HIS69 |
| A | SO41105 |
| B | PHE99 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1112 |
| Chain | Residue |
| A | HOH2039 |
| A | HOH2080 |
| A | HOH2122 |
| A | HOH2215 |
| B | ARG14 |
| B | ILE15 |
| B | GLY16 |
| B | GLY17 |
| B | PRO63 |
| B | SO41102 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT B 1100 |
| Chain | Residue |
| A | LYS70 |
| A | GOL1102 |
| B | LYS55 |
| B | SO41103 |
| B | HOH2170 |
| B | HOH2171 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 1101 |
| Chain | Residue |
| A | LYS55 |
| A | LYS70 |
| B | ARG14 |
| B | LYS70 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1102 |
| Chain | Residue |
| A | ARG14 |
| A | GLY17 |
| A | SO41112 |
| A | HOH2040 |
| A | HOH2042 |
| A | HOH2080 |
| A | HOH2215 |
| B | ILE15 |
| B | GLY16 |
| B | GLY17 |
| B | PRO63 |
| site_id | BC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1103 |
| Chain | Residue |
| A | HIS69 |
| A | GOL1102 |
| A | HOH2157 |
| A | HOH2158 |
| B | PRO1 |
| B | HIS69 |
| B | ACT1100 |
| B | HOH2168 |
| B | HOH2169 |
| B | HOH2172 |
| B | HOH2173 |
| site_id | BC4 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR CHAIN C OF INHIBITOR MOLECULE JG365 |
| Chain | Residue |
| A | ILE84 |
| A | HOH2107 |
| A | HOH2112 |
| A | HOH2116 |
| A | HOH2117 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP29 |
| B | VAL32 |
| B | GLY48 |
| B | GLY49 |
| B | VAL82 |
| B | ILE84 |
| B | HOH2098 |
| B | HOH2099 |
| A | ARG8 |
| A | ASP25 |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | ILE47 |
| A | GLY48 |
| A | GLY49 |
| A | ILE50 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
| Chain | Residue | Details |
| A | ALA22-ILE33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| A | THR26 | |
| B | ASP25 | |
| B | THR26 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| B | ASP25 | |
