2JCK

Crystal structure of alpha-1,3 Galactosyltransferase (R365K) in complex with UDP and 2 manganese ion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005975	biological_process	carbohydrate metabolic process
A	0016020	cellular_component	membrane
A	0016758	molecular_function	hexosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN A3362

Chain	Residue
A	ASP1225
A	ASP1227
A	HOH2406
A	UDP3361

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN A3363

Chain	Residue
A	GLN1247
A	HIS1280
A	GLU1317
A	HOH2407

---

site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE UDP A3361

Chain	Residue
A	LYS1104
A	PHE1134
A	ALA1135
A	VAL1136
A	TYR1139
A	ILE1198
A	SER1199
A	ARG1202
A	ASP1225
A	VAL1226
A	ASP1227
A	GLU1360
A	HOH2257
A	HOH2403
A	HOH2404
A	HOH2405
A	HOH2407
A	MN3362
A	LYS1102

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"11179209","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G8O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11179209","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11592969","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12011052","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G93","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O7Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JCK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VS3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VS4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VS5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VXL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11179209","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11592969","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12011052","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1G93","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O7Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JCK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VS3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VS4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VS5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VXL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12011052","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O7Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VS4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1g8o

Chain	Residue	Details
A	GLU1317

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1g8o

Chain	Residue	Details
A	GLU1317
A	TRP1314

---

site_id	MCSA1
Number of Residues	5
Details	M-CSA 356

Chain	Residue	Details
A	GLN1247	electrostatic stabiliser, hydrogen bond donor
A	HIS1280	electrostatic stabiliser, hydrogen bond donor
A	TRP1314	electrostatic stabiliser, hydrogen bond donor
A	GLU1317	activator, covalently attached, electrostatic stabiliser, nucleofuge, nucleophile
A	TRP1356	electrostatic stabiliser, hydrogen bond donor

---