2JAN

TYROSYL-TRNA SYNTHETASE FROM MYCOBACTERIUM TUBERCULOSIS IN UNLIGANDED STATE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003723	molecular_function	RNA binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004831	molecular_function	tyrosine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006412	biological_process	translation
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006437	biological_process	tyrosyl-tRNA aminoacylation
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016874	molecular_function	ligase activity
A	0042803	molecular_function	protein homodimerization activity
A	0043039	biological_process	tRNA aminoacylation
B	0000166	molecular_function	nucleotide binding
B	0003723	molecular_function	RNA binding
B	0004812	molecular_function	aminoacyl-tRNA ligase activity
B	0004831	molecular_function	tyrosine-tRNA ligase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006412	biological_process	translation
B	0006418	biological_process	tRNA aminoacylation for protein translation
B	0006437	biological_process	tyrosyl-tRNA aminoacylation
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0016874	molecular_function	ligase activity
B	0042803	molecular_function	protein homodimerization activity
B	0043039	biological_process	tRNA aminoacylation
C	0000166	molecular_function	nucleotide binding
C	0003723	molecular_function	RNA binding
C	0004812	molecular_function	aminoacyl-tRNA ligase activity
C	0004831	molecular_function	tyrosine-tRNA ligase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006412	biological_process	translation
C	0006418	biological_process	tRNA aminoacylation for protein translation
C	0006437	biological_process	tyrosyl-tRNA aminoacylation
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0016874	molecular_function	ligase activity
C	0042803	molecular_function	protein homodimerization activity
C	0043039	biological_process	tRNA aminoacylation
D	0000166	molecular_function	nucleotide binding
D	0003723	molecular_function	RNA binding
D	0004812	molecular_function	aminoacyl-tRNA ligase activity
D	0004831	molecular_function	tyrosine-tRNA ligase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006412	biological_process	translation
D	0006418	biological_process	tRNA aminoacylation for protein translation
D	0006437	biological_process	tyrosyl-tRNA aminoacylation
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0016874	molecular_function	ligase activity
D	0042803	molecular_function	protein homodimerization activity
D	0043039	biological_process	tRNA aminoacylation

Functional Information from PROSITE/UniProt

site_id	PS00178
Number of Residues	11
Details	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. Pt.APsLHAGHL

Chain	Residue	Details
A	PRO41-LEU51

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	228
Details	Domain: {"description":"S4 RNA-binding","evidences":[{"source":"HAMAP-Rule","id":"MF_02006","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	36
Details	Motif: {"description":"'HIGH' region"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	16
Details	Motif: {"description":"'KMSKS' region"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_02006","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1d2r

Chain	Residue	Details
A	LYS231
A	LYS234

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1d2r

Chain	Residue	Details
B	LYS231
B	LYS234

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1d2r

Chain	Residue	Details
C	LYS231
C	LYS234

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1d2r

Chain	Residue	Details
D	LYS231
D	LYS234

---

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1d2r

Chain	Residue	Details
A	LYS231
A	ASP83
A	LYS234
A	ARG87

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