2JAJ
DDAH1 complexed with L-257
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003073 | biological_process | regulation of systemic arterial blood pressure |
| A | 0005829 | cellular_component | cytosol |
| A | 0006525 | biological_process | arginine metabolic process |
| A | 0006527 | biological_process | L-arginine catabolic process |
| A | 0008285 | biological_process | negative regulation of cell population proliferation |
| A | 0016403 | molecular_function | dimethylargininase activity |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0036487 | molecular_function | nitric-oxide synthase inhibitor activity |
| A | 0043116 | biological_process | negative regulation of vascular permeability |
| A | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
| A | 0045766 | biological_process | positive regulation of angiogenesis |
| A | 0046209 | biological_process | nitric oxide metabolic process |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1900038 | biological_process | negative regulation of cellular response to hypoxia |
| B | 0003073 | biological_process | regulation of systemic arterial blood pressure |
| B | 0005829 | cellular_component | cytosol |
| B | 0006525 | biological_process | arginine metabolic process |
| B | 0006527 | biological_process | L-arginine catabolic process |
| B | 0008285 | biological_process | negative regulation of cell population proliferation |
| B | 0016403 | molecular_function | dimethylargininase activity |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0036487 | molecular_function | nitric-oxide synthase inhibitor activity |
| B | 0043116 | biological_process | negative regulation of vascular permeability |
| B | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
| B | 0045766 | biological_process | positive regulation of angiogenesis |
| B | 0046209 | biological_process | nitric oxide metabolic process |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1900038 | biological_process | negative regulation of cellular response to hypoxia |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE D20 A 500 |
| Chain | Residue |
| A | LEU29 |
| A | VAL267 |
| A | ASP268 |
| A | THR272 |
| A | CYS273 |
| A | HOH2077 |
| A | HOH2126 |
| A | ASP72 |
| A | PHE75 |
| A | ASP78 |
| A | ARG97 |
| A | HIS172 |
| A | LYS174 |
| A | SER175 |
| A | ASN220 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE D20 B 500 |
| Chain | Residue |
| B | LEU29 |
| B | ASP72 |
| B | PHE75 |
| B | ASP78 |
| B | ARG97 |
| B | HIS172 |
| B | LYS174 |
| B | SER175 |
| B | VAL267 |
| B | ASP268 |
| B | THR272 |
| B | CYS273 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"19663506","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"19663506","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"P56965","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"9874257","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1jdw |
| Chain | Residue | Details |
| A | CYS273 | |
| A | HIS172 | |
| A | ASP126 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1jdw |
| Chain | Residue | Details |
| B | CYS273 | |
| B | HIS172 | |
| B | ASP126 |
