2J9E

Structure of GlnK1 with bound effectors indicates regulatory mechanism for ammonia uptake

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006808	biological_process	regulation of nitrogen utilization
A	0030234	molecular_function	enzyme regulator activity
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006808	biological_process	regulation of nitrogen utilization
B	0030234	molecular_function	enzyme regulator activity
C	0000166	molecular_function	nucleotide binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006808	biological_process	regulation of nitrogen utilization
C	0030234	molecular_function	enzyme regulator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 1116

Chain	Residue
A	GLU14
A	HOH2111
A	HOH2112
B	GLU79
C	ILE15
C	LYS18

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1117

Chain	Residue
A	LYS3
B	LYS3
C	LYS3

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1118

Chain	Residue
A	ARG103
B	ARG82

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA B 1119

Chain	Residue
B	GLU14
B	LYS17
C	HOH2087

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 1116

Chain	Residue
C	ATP1115
C	HOH2052
C	HOH2066
C	HOH2137

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL C 1117

Chain	Residue
A	HOH2005
C	LYS3
C	GLU5
C	LYS60
C	GLU62
C	HOH2010

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 1118

Chain	Residue
B	ARG103
C	GLY84

---

site_id	AC8
Number of Residues	29
Details	BINDING SITE FOR RESIDUE ATP A 1115

Chain	Residue
A	ILE7
A	GLY35
A	ARG36
A	GLY37
A	VAL38
A	GLN39
A	LYS58
A	PRO86
A	GLY87
A	ASP88
A	GLY89
A	LYS90
A	HOH2083
A	HOH2103
A	HOH2104
A	HOH2105
A	HOH2106
A	HOH2107
A	HOH2108
A	HOH2109
A	HOH2110
C	GLY27
C	MET28
C	THR29
C	GLU62
C	LEU63
C	VAL64
C	ARG101
C	ARG103

---

site_id	AC9
Number of Residues	24
Details	BINDING SITE FOR RESIDUE ATP B 1118

Chain	Residue
A	GLY27
A	MET28
A	THR29
A	GLU62
A	LEU63
A	VAL64
A	ARG101
A	ARG103
B	ILE7
B	GLY35
B	ARG36
B	GLY37
B	VAL38
B	GLN39
B	LYS58
B	PRO86
B	GLY87
B	ASP88
B	GLY89
B	LYS90
B	HOH2105
B	HOH2135
B	HOH2136
B	HOH2137

---

site_id	BC1
Number of Residues	27
Details	BINDING SITE FOR RESIDUE ATP C 1115

Chain	Residue
C	HOH2052
C	HOH2065
C	HOH2066
C	HOH2137
C	HOH2138
C	HOH2139
C	HOH2140
B	GLY27
B	MET28
B	THR29
B	GLU62
B	VAL64
B	ARG101
B	ARG103
B	HIS115
C	ILE7
C	GLY35
C	ARG36
C	GLY37
C	VAL38
C	LYS58
C	PRO86
C	GLY87
C	ASP88
C	GLY89
C	LYS90
C	MG1116

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE AKG C 1119

Chain	Residue
C	GLU50
C	TYR51
C	ILE52
C	VAL53
C	ASP54
C	HOH2141
C	HOH2142
C	HOH2143

---

Functional Information from PROSITE/UniProt

site_id	PS00638
Number of Residues	14
Details	PII_GLNB_CTER P-II protein C-terminal region signature. TgnpGDGKIFVipV

Chain	Residue	Details
A	THR83-VAL96

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	BINDING: BINDING => ECO:0000269|PubMed:17203075, ECO:0007744|PDB:2J9C, ECO:0007744|PDB:2J9E

Chain	Residue	Details
A	THR29
B	ARG101
C	THR29
C	VAL38
C	VAL64
C	PRO86
C	ARG101
A	VAL38
A	VAL64
A	PRO86
A	ARG101
B	THR29
B	VAL38
B	VAL64
B	PRO86

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:17203075

Chain	Residue	Details
A	ILE52
B	ILE52
C	ILE52

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:17203075, ECO:0007744|PDB:2J9D

Chain	Residue	Details
A	ASP88
B	ASP88
C	ASP88

---