2J8F

Crystal structure of the modular Cpl-1 endolysin complexed with a peptidoglycan analogue (E94Q mutant in complex with a disaccharide- pentapeptide)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0008152	biological_process	metabolic process
A	0009253	biological_process	peptidoglycan catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PROSITE/UniProt

site_id	PS00953
Number of Residues	34
Details	GLYCOSYL_HYDROL_F25_1 Glycosyl hydrolases family 25 active site signature. DVsshNGyditgileqm.....GttntIIKiSESttYlN

Chain	Residue	Details
A	ASP10-ASN43

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01252

Chain	Residue	Details
A	ASP10
A	ASP92
A	GLN94

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 774

Chain	Residue	Details
A	ASP10	activator, electrostatic stabiliser, increase nucleophilicity, proton acceptor, proton donor
A	ASP92	proton donor
A	GLN94	activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor
A	ASP182	proton acceptor

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