Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2J7P

GMPPNP-stabilized NG domain complex of the SRP GTPases Ffh and FtsY

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0048500	cellular_component	signal recognition particle
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0048500	cellular_component	signal recognition particle
D	0003924	molecular_function	GTPase activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0006612	biological_process	protein targeting to membrane
D	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
E	0003924	molecular_function	GTPase activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0006612	biological_process	protein targeting to membrane
E	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A1299

Chain	Residue
A	ARG181

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A1300

Chain	Residue
A	ARG286
A	HOH2147
A	HOH2151

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A1302

Chain	Residue
A	HOH2103
A	HOH2107

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A1401

Chain	Residue
A	HOH2084
A	HOH2100
A	THR112
A	GNP1400
A	HOH2073

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD B1298

Chain	Residue
A	HOH2016

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD B1299

Chain	Residue
B	ARG35
B	MET39

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD B1300

Chain	Residue
B	ARG181

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD B1301

Chain	Residue
B	HOH2159
B	HOH2162

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD B1302

Chain	Residue
B	HOH2085

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B1401

Chain	Residue
B	THR112
B	GNP1400
B	HOH2087
B	HOH2122
B	HOH2165

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD D1308

Chain	Residue
D	SER47
D	ARG271

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD D1309

Chain	Residue
D	GLY25
D	HOH2017

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD D1310

Chain	Residue
D	GLU66
D	LYS69

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D1401

Chain	Residue
D	THR116
D	GNP1400
D	HOH2047
D	HOH2054
D	HOH2072

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K D1402

Chain	Residue
D	LEU257
D	GLY259
D	ALA261
D	HOH2027
D	HOH2106
D	HOH2111

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD E1308

Chain	Residue
E	LYS199
E	ASN201

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG E1401

Chain	Residue
E	THR116
E	GNP1400
E	HOH2037
E	HOH2042
E	HOH2061

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E1402

Chain	Residue
E	LEU257
E	GLY259
E	ALA261
E	HOH2020
E	HOH2091
E	HOH2095

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A1297

Chain	Residue
A	ARG128
A	ARG181

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A1298

Chain	Residue
A	GLN137
D	GLU284
D	HOH2117

site_id	CC3
Number of Residues	30
Details	BINDING SITE FOR RESIDUE GNP A1400

Chain	Residue
A	GLN107
A	GLY108
A	SER109
A	GLY110
A	LYS111
A	THR112
A	THR113
A	LYS117
A	ASP135
A	ARG138
A	GLN144
A	GLY190
A	LYS246
A	ASP248
A	GLY271
A	VAL272
A	SER273
A	GLU274
A	MG1401
A	HOH2069
A	HOH2073
A	HOH2075
A	HOH2084
A	HOH2100
A	HOH2152
D	ASN111
D	ARG142
D	LEU196
D	GNP1400
D	HOH2124

site_id	CC4
Number of Residues	31
Details	BINDING SITE FOR RESIDUE GNP B1400

Chain	Residue
B	LYS246
B	ASP248
B	GLY271
B	VAL272
B	SER273
B	GLU274
B	MG1401
B	HOH2079
B	HOH2081
B	HOH2087
B	HOH2088
B	HOH2092
B	HOH2122
B	HOH2164
B	HOH2165
E	ASN111
E	ARG142
E	LEU196
E	GNP1400
E	HOH2029
B	GLN107
B	GLY108
B	SER109
B	GLY110
B	LYS111
B	THR112
B	THR113
B	LYS117
B	ARG138
B	GLN144
B	GLY190

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D1306

Chain	Residue
D	PRO291
D	PHE292
D	ASP293
D	PHE297
D	HOH2123

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D1307

Chain	Residue
A	GLN193
D	GLY259
D	THR260
D	ALA261
D	HOH2105

site_id	CC7
Number of Residues	28
Details	BINDING SITE FOR RESIDUE GNP D1400

Chain	Residue
A	GLN107
A	ARG138
A	GNP1400
D	ASN111
D	GLY112
D	VAL113
D	GLY114
D	LYS115
D	THR116
D	THR117
D	LYS121
D	ARG142
D	GLN148
D	GLY194
D	LYS256
D	ASP258
D	GLY281
D	VAL282
D	GLY283
D	GLU284
D	MG1401
D	HOH2038
D	HOH2047
D	HOH2049
D	HOH2054
D	HOH2072
D	HOH2124
D	HOH2125

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E1306

Chain	Residue
B	LEU106
B	GLN193
E	GLY259
E	THR260
E	ALA261
E	HOH2090

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO E1307

Chain	Residue
E	SER157
E	PRO159

site_id	DC1
Number of Residues	28
Details	BINDING SITE FOR RESIDUE GNP E1400

Chain	Residue
B	GLN107
B	ARG138
B	GNP1400
B	HOH2092
E	ASN111
E	GLY112
E	VAL113
E	GLY114
E	LYS115
E	THR116
E	THR117
E	LYS121
E	ARG142
E	GLN148
E	GLY194
E	LYS256
E	ASP258
E	GLY281
E	VAL282
E	GLY283
E	GLU284
E	MG1401
E	HOH2036
E	HOH2037
E	HOH2042
E	HOH2061
E	HOH2111
E	HOH2112

Functional Information from PROSITE/UniProt

site_id	PS00300
Number of Residues	14
Details	SRP54 SRP54-type proteins GTP-binding domain signature. PIyFAGVSEkPegL

Chain	Residue	Details
A	PRO266-LEU279
D	PRO276-LEU289

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00306

Chain	Residue	Details
A	LEU106
A	THR188
A	LYS246
B	LEU106
B	THR188
B	LYS246

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)