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2J5X

STRUCTURE OF THE SMALL G PROTEIN ARF6 IN COMPLEX WITH GTPGAMMAS

Replaces:  1HFV
Functional Information from GO Data
ChainGOidnamespacecontents
A0001726cellular_componentruffle
A0001889biological_processliver development
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0005938cellular_componentcell cortex
A0006886biological_processintracellular protein transport
A0007155biological_processcell adhesion
A0007399biological_processnervous system development
A0010975biological_processregulation of neuron projection development
A0010976biological_processpositive regulation of neuron projection development
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016192biological_processvesicle-mediated transport
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0030139cellular_componentendocytic vesicle
A0030154biological_processcell differentiation
A0030496cellular_componentmidbody
A0030838biological_processpositive regulation of actin filament polymerization
A0030866biological_processcortical actin cytoskeleton organization
A0031527cellular_componentfilopodium membrane
A0031901cellular_componentearly endosome membrane
A0031996molecular_functionthioesterase binding
A0032154cellular_componentcleavage furrow
A0032456biological_processendocytic recycling
A0034394biological_processprotein localization to cell surface
A0035020biological_processregulation of Rac protein signal transduction
A0035591molecular_functionsignaling adaptor activity
A0036010biological_processprotein localization to endosome
A0042995cellular_componentcell projection
A0048261biological_processnegative regulation of receptor-mediated endocytosis
A0048488biological_processsynaptic vesicle endocytosis
A0050714biological_processpositive regulation of protein secretion
A0051301biological_processcell division
A0051489biological_processregulation of filopodium assembly
A0051549biological_processpositive regulation of keratinocyte migration
A0055037cellular_componentrecycling endosome
A0055038cellular_componentrecycling endosome membrane
A0060998biological_processregulation of dendritic spine development
A0070062cellular_componentextracellular exosome
A0072659biological_processprotein localization to plasma membrane
A0090162biological_processestablishment of epithelial cell polarity
A0090543cellular_componentFlemming body
A0097178biological_processruffle assembly
A0097284biological_processhepatocyte apoptotic process
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099562biological_processmaintenance of postsynaptic density structure
A0120183biological_processpositive regulation of focal adhesion disassembly
A1902217biological_processerythrocyte apoptotic process
A1903078biological_processpositive regulation of protein localization to plasma membrane
A1903438biological_processpositive regulation of mitotic cytokinetic process
A1905345biological_processprotein localization to cleavage furrow
A1905606biological_processregulation of presynapse assembly
A1990090biological_processcellular response to nerve growth factor stimulus
A2000009biological_processnegative regulation of protein localization to cell surface
A2000171biological_processnegative regulation of dendrite development
B0001726cellular_componentruffle
B0001889biological_processliver development
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0005938cellular_componentcell cortex
B0006886biological_processintracellular protein transport
B0007155biological_processcell adhesion
B0007399biological_processnervous system development
B0010975biological_processregulation of neuron projection development
B0010976biological_processpositive regulation of neuron projection development
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0016192biological_processvesicle-mediated transport
B0016787molecular_functionhydrolase activity
B0019003molecular_functionGDP binding
B0030139cellular_componentendocytic vesicle
B0030154biological_processcell differentiation
B0030496cellular_componentmidbody
B0030838biological_processpositive regulation of actin filament polymerization
B0030866biological_processcortical actin cytoskeleton organization
B0031527cellular_componentfilopodium membrane
B0031901cellular_componentearly endosome membrane
B0031996molecular_functionthioesterase binding
B0032154cellular_componentcleavage furrow
B0032456biological_processendocytic recycling
B0034394biological_processprotein localization to cell surface
B0035020biological_processregulation of Rac protein signal transduction
B0035591molecular_functionsignaling adaptor activity
B0036010biological_processprotein localization to endosome
B0042995cellular_componentcell projection
B0048261biological_processnegative regulation of receptor-mediated endocytosis
B0048488biological_processsynaptic vesicle endocytosis
B0050714biological_processpositive regulation of protein secretion
B0051301biological_processcell division
B0051489biological_processregulation of filopodium assembly
B0051549biological_processpositive regulation of keratinocyte migration
B0055037cellular_componentrecycling endosome
B0055038cellular_componentrecycling endosome membrane
B0060998biological_processregulation of dendritic spine development
B0070062cellular_componentextracellular exosome
B0072659biological_processprotein localization to plasma membrane
B0090162biological_processestablishment of epithelial cell polarity
B0090543cellular_componentFlemming body
B0097178biological_processruffle assembly
B0097284biological_processhepatocyte apoptotic process
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099562biological_processmaintenance of postsynaptic density structure
B0120183biological_processpositive regulation of focal adhesion disassembly
B1902217biological_processerythrocyte apoptotic process
B1903078biological_processpositive regulation of protein localization to plasma membrane
B1903438biological_processpositive regulation of mitotic cytokinetic process
B1905345biological_processprotein localization to cleavage furrow
B1905606biological_processregulation of presynapse assembly
B1990090biological_processcellular response to nerve growth factor stimulus
B2000009biological_processnegative regulation of protein localization to cell surface
B2000171biological_processnegative regulation of dendrite development
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 200
ChainResidue
ATHR27
ATHR44
AGSP190
AHOH2004
AHOH2010

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B 200
ChainResidue
BHOH2006
BTHR27
BTHR44
BGSP190
BHOH2002

site_idAC3
Number of Residues25
DetailsBINDING SITE FOR RESIDUE GSP A 190
ChainResidue
AASP22
AALA23
AALA24
AGLY25
ALYS26
ATHR27
ATHR28
ATHR41
APRO43
ATHR44
AGLY65
AGLY66
AASN122
ALYS123
AASP125
ALEU126
ACYS155
AALA156
ATHR157
AMG200
AHOH2004
AHOH2010
BVAL45
BGLY46
BPHE47

site_idAC4
Number of Residues22
DetailsBINDING SITE FOR RESIDUE GSP B 190
ChainResidue
AGLY46
APHE47
BALA23
BALA24
BGLY25
BLYS26
BTHR27
BTHR28
BTHR41
BTHR44
BGLY66
BHIS76
BASN122
BLYS123
BASP125
BCYS155
BALA156
BTHR157
BMG200
BHOH2002
BHOH2006
BHOH2012

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:16099990, ECO:0000269|PubMed:19644450, ECO:0000269|PubMed:21170023, ECO:0000269|PubMed:22939626, ECO:0000269|PubMed:23940353
ChainResidueDetails
AALA24
BALA156
AILE42
AVAL64
ALYS123
AALA156
BALA24
BILE42
BVAL64
BLYS123

site_idSWS_FT_FI2
Number of Residues2
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:7589240
ChainResidueDetails
ALYS3
BLYS3

site_idSWS_FT_FI3
Number of Residues2
DetailsLIPID: N6-myristoyl lysine => ECO:0000269|PubMed:32103017
ChainResidueDetails
AVAL4
BVAL4

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLN67

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
BGLN67

222624

PDB entries from 2024-07-17

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