2J41

Crystal structure of Staphylococcus aureus guanylate monophosphate kinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004385	molecular_function	GMP kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006163	biological_process	purine nucleotide metabolic process
A	0009179	biological_process	purine ribonucleoside diphosphate metabolic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0046037	biological_process	GMP metabolic process
A	0046710	biological_process	GDP metabolic process
B	0000166	molecular_function	nucleotide binding
B	0004385	molecular_function	GMP kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006163	biological_process	purine nucleotide metabolic process
B	0009179	biological_process	purine ribonucleoside diphosphate metabolic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0046037	biological_process	GMP metabolic process
B	0046710	biological_process	GDP metabolic process
C	0000166	molecular_function	nucleotide binding
C	0004385	molecular_function	GMP kinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006163	biological_process	purine nucleotide metabolic process
C	0009179	biological_process	purine ribonucleoside diphosphate metabolic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0046037	biological_process	GMP metabolic process
C	0046710	biological_process	GDP metabolic process
D	0000166	molecular_function	nucleotide binding
D	0004385	molecular_function	GMP kinase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006163	biological_process	purine nucleotide metabolic process
D	0009179	biological_process	purine ribonucleoside diphosphate metabolic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0046037	biological_process	GMP metabolic process
D	0046710	biological_process	GDP metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 C1198

Chain	Residue
C	GLY16
C	VAL17
C	GLY18
C	LYS19
C	GLY20
C	5GP1200
C	HOH2127
C	HOH2128
C	HOH2129

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B1206

Chain	Residue
B	GLY16
B	VAL17
B	GLY18
B	LYS19
B	GLY20
B	5GP1208
B	HOH2110
B	HOH2111

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 D1207

Chain	Residue
D	GLY16
D	VAL17
D	GLY18
D	LYS19
D	GLY20
D	5GP1210
D	HOH2126
D	HOH2127
D	HOH2135

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A1198

Chain	Residue
A	PRO14
A	GLY16
A	VAL17
A	GLY18
A	LYS19
A	GLY20
A	HOH2095

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D1208

Chain	Residue
D	ARG43
D	GLN44
D	ASN81
D	HOH2128
D	HOH2129
D	HOH2130
D	HOH2131
D	HOH2132

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K B1207

Chain	Residue
B	TYR36
B	SER39
B	GLU103
B	5GP1208
B	HOH2029
B	HOH2030
B	HOH2083

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C1199

Chain	Residue
C	TYR36
C	SER39
C	GLU103
C	5GP1200
C	HOH2034
C	HOH2054

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K D1209

Chain	Residue
D	TYR36
D	SER39
D	GLU103
D	5GP1210
D	HOH2028

---

site_id	AC9
Number of Residues	21
Details	BINDING SITE FOR RESIDUE 5GP C1200

Chain	Residue
C	LYS19
C	SER39
C	ARG43
C	ARG46
C	TYR55
C	GLU74
C	ALA76
C	TYR78
C	TYR83
C	GLY84
C	THR85
C	GLU103
C	ILE104
C	GLU105
C	GLY108
C	SO41198
C	K1199
C	HOH2044
C	HOH2127
C	HOH2129
C	HOH2130

---

site_id	BC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 5GP D1210

Chain	Residue
D	LYS19
D	SER39
D	ARG43
D	TYR55
D	GLU74
D	TYR78
D	TYR83
D	GLY84
D	THR85
D	GLU103
D	ILE104
D	GLU105
D	GLY108
D	SO41207
D	K1209
D	HOH2127
D	HOH2133
D	HOH2134
D	HOH2135

---

site_id	BC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 5GP B1208

Chain	Residue
B	LYS19
B	SER39
B	ARG43
B	TYR55
B	GLU74
B	ALA76
B	TYR78
B	TYR83
B	GLY84
B	THR85
B	GLU103
B	ILE104
B	GLU105
B	GLY108
B	SO41206
B	K1207
B	HOH2039
B	HOH2111

---

Functional Information from PROSITE/UniProt

site_id	PS00856
Number of Residues	18
Details	GUANYLATE_KINASE_1 Guanylate kinase-like signature. TTRqmRegEvdGvdYfFK

Chain	Residue	Details
A	THR41-LYS58

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00328","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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