2J3N
X-ray structure of human thioredoxin reductase 1
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
A | 0045454 | biological_process | cell redox homeostasis |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
B | 0045454 | biological_process | cell redox homeostasis |
B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
C | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
C | 0045454 | biological_process | cell redox homeostasis |
C | 0050660 | molecular_function | flavin adenine dinucleotide binding |
D | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
D | 0045454 | biological_process | cell redox homeostasis |
D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
E | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
E | 0045454 | biological_process | cell redox homeostasis |
E | 0050660 | molecular_function | flavin adenine dinucleotide binding |
F | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
F | 0016491 | molecular_function | oxidoreductase activity |
F | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
F | 0045454 | biological_process | cell redox homeostasis |
F | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 30 |
Details | BINDING SITE FOR RESIDUE FAD A 600 |
Chain | Residue |
A | ILE18 |
A | GLY57 |
A | THR58 |
A | CYS59 |
A | CYS64 |
A | LYS67 |
A | TYR131 |
A | GLY132 |
A | ALA160 |
A | THR161 |
A | GLY162 |
A | GLY19 |
A | TYR200 |
A | VAL201 |
A | ARG293 |
A | ASP334 |
A | GLU341 |
A | LEU342 |
A | THR343 |
A | PRO344 |
A | HOH2007 |
B | HIS472 |
A | GLY20 |
B | HOH2008 |
A | GLY21 |
A | SER22 |
A | GLY23 |
A | LEU41 |
A | ASP42 |
A | PHE43 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE NAP A 601 |
Chain | Residue |
A | ARG166 |
A | LEU168 |
A | GLY197 |
A | ALA198 |
A | SER199 |
A | ARG221 |
A | SER222 |
A | ARG226 |
A | ILE291 |
A | GLY292 |
A | ARG293 |
A | LYS315 |
A | GLU341 |
site_id | AC3 |
Number of Residues | 30 |
Details | BINDING SITE FOR RESIDUE FAD B 600 |
Chain | Residue |
A | HIS472 |
B | ILE18 |
B | GLY19 |
B | GLY21 |
B | SER22 |
B | GLY23 |
B | LEU41 |
B | ASP42 |
B | PHE43 |
B | GLY57 |
B | THR58 |
B | CYS59 |
B | GLY63 |
B | CYS64 |
B | LYS67 |
B | ALA130 |
B | TYR131 |
B | GLY132 |
B | ALA160 |
B | THR161 |
B | GLY162 |
B | TYR200 |
B | VAL201 |
B | ARG293 |
B | ASP334 |
B | GLU341 |
B | LEU342 |
B | THR343 |
B | PRO344 |
B | ALA346 |
site_id | AC4 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE NAP B 601 |
Chain | Residue |
B | ARG166 |
B | LEU168 |
B | GLY197 |
B | ALA198 |
B | SER199 |
B | ARG221 |
B | SER222 |
B | ILE223 |
B | ARG226 |
B | VAL252 |
B | ILE291 |
B | GLY292 |
B | ARG293 |
B | LYS315 |
B | GLU341 |
site_id | AC5 |
Number of Residues | 31 |
Details | BINDING SITE FOR RESIDUE FAD C 600 |
Chain | Residue |
C | CYS59 |
C | VAL62 |
C | GLY63 |
C | CYS64 |
C | LYS67 |
C | TYR131 |
C | GLY132 |
C | ALA160 |
C | THR161 |
C | GLY162 |
C | SER180 |
C | TYR200 |
C | ASP334 |
C | GLU341 |
C | LEU342 |
C | THR343 |
C | PRO344 |
C | ALA346 |
C | HOH2001 |
D | HIS472 |
C | GLY19 |
C | GLY20 |
C | GLY21 |
C | SER22 |
C | GLY23 |
C | LEU41 |
C | ASP42 |
C | PHE43 |
C | VAL44 |
C | GLY57 |
C | THR58 |
site_id | AC6 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE NAP C 601 |
Chain | Residue |
C | ARG166 |
C | LEU168 |
C | GLY197 |
C | ALA198 |
C | SER199 |
C | ARG221 |
C | SER222 |
C | ARG226 |
C | ILE291 |
C | GLY292 |
C | ARG293 |
C | GLU341 |
C | HOH2007 |
site_id | AC7 |
Number of Residues | 34 |
Details | BINDING SITE FOR RESIDUE FAD D 600 |
Chain | Residue |
C | HIS472 |
C | PRO473 |
C | HOH2006 |
D | ILE18 |
D | GLY19 |
D | GLY20 |
D | GLY21 |
D | SER22 |
D | GLY23 |
D | LEU41 |
D | ASP42 |
D | PHE43 |
D | GLY57 |
D | THR58 |
D | CYS59 |
D | VAL62 |
D | GLY63 |
D | CYS64 |
D | LYS67 |
D | TYR131 |
D | GLY132 |
D | ALA160 |
D | THR161 |
D | GLY162 |
D | TYR200 |
D | VAL201 |
D | ARG293 |
D | ASP334 |
D | GLU341 |
D | LEU342 |
D | THR343 |
D | PRO344 |
D | ALA346 |
D | HOH2006 |
site_id | AC8 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE NAP D 601 |
Chain | Residue |
D | LEU168 |
D | ALA198 |
D | SER199 |
D | ARG221 |
D | SER222 |
D | ARG226 |
D | VAL252 |
D | ILE291 |
D | GLY292 |
D | GLU341 |
site_id | AC9 |
Number of Residues | 29 |
Details | BINDING SITE FOR RESIDUE FAD E 600 |
Chain | Residue |
E | GLY19 |
E | GLY20 |
E | GLY21 |
E | SER22 |
E | GLY23 |
E | ASP42 |
E | PHE43 |
E | VAL44 |
E | GLY57 |
E | THR58 |
E | CYS59 |
E | VAL62 |
E | GLY63 |
E | CYS64 |
E | LYS67 |
E | TYR131 |
E | GLY132 |
E | ALA160 |
E | THR161 |
E | GLY162 |
E | TYR200 |
E | ARG293 |
E | ASP334 |
E | GLU341 |
E | LEU342 |
E | THR343 |
E | PRO344 |
F | HIS472 |
F | PRO473 |
site_id | BC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE NAP E 601 |
Chain | Residue |
E | ARG166 |
E | ALA198 |
E | SER199 |
E | ARG221 |
E | SER222 |
E | ARG226 |
E | GLY227 |
E | PHE228 |
E | ILE291 |
E | GLY292 |
E | ARG293 |
E | LYS315 |
E | GLU341 |
site_id | BC2 |
Number of Residues | 29 |
Details | BINDING SITE FOR RESIDUE FAD F 600 |
Chain | Residue |
E | HIS472 |
F | GLY19 |
F | GLY21 |
F | SER22 |
F | GLY23 |
F | ASP42 |
F | PHE43 |
F | GLY57 |
F | THR58 |
F | CYS59 |
F | VAL62 |
F | GLY63 |
F | CYS64 |
F | LYS67 |
F | TYR131 |
F | GLY132 |
F | THR161 |
F | GLY162 |
F | SER180 |
F | TYR200 |
F | VAL201 |
F | ARG293 |
F | ASP334 |
F | GLU341 |
F | LEU342 |
F | THR343 |
F | PRO344 |
F | ALA346 |
F | HOH2004 |
site_id | BC3 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE NAP F 601 |
Chain | Residue |
F | ARG166 |
F | LEU168 |
F | ALA198 |
F | SER199 |
F | ARG221 |
F | SER222 |
F | ARG226 |
F | ILE291 |
F | GLY292 |
F | ARG293 |
F | GLU341 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MPD A 701 |
Chain | Residue |
A | SER404 |
A | VAL478 |
A | THR481 |
A | SER483 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MPD B 700 |
Chain | Residue |
A | LEU75 |
A | LEU76 |
B | GLN72 |
B | LEU76 |
B | ALA79 |
site_id | BC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MPD B 701 |
Chain | Residue |
B | SER415 |
B | ARG416 |
B | ASN418 |
C | GLU122 |
site_id | BC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MPD D 700 |
Chain | Residue |
C | GLN72 |
C | LEU76 |
C | ALA79 |
site_id | BC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MPD F 700 |
Chain | Residue |
E | LEU76 |
E | ALA79 |
F | GLN72 |
F | LEU75 |
F | LEU76 |
F | ALA79 |
F | HOH2007 |
Functional Information from PROSITE/UniProt
site_id | PS00076 |
Number of Residues | 11 |
Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCIP |
Chain | Residue | Details |
A | GLY56-PRO66 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Proton acceptor => ECO:0000250 |
Chain | Residue | Details |
A | HIS472 | |
B | HIS472 | |
C | HIS472 | |
D | HIS472 | |
E | HIS472 | |
F | HIS472 |
site_id | SWS_FT_FI2 |
Number of Residues | 72 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17512005, ECO:0007744|PDB:2J3N |
Chain | Residue | Details |
A | GLY172 | |
A | LEU465 | |
A | VAL484 | |
A | HIS472 | |
B | GLY172 | |
B | LYS192 | |
B | PHE208 | |
B | GLY213 | |
B | GLU281 | |
B | ILE316 | |
B | GLN348 | |
A | LYS192 | |
B | PRO371 | |
B | GLY442 | |
B | LEU465 | |
B | VAL484 | |
B | HIS472 | |
C | GLY172 | |
C | LYS192 | |
C | PHE208 | |
C | GLY213 | |
C | GLU281 | |
A | PHE208 | |
C | ILE316 | |
C | GLN348 | |
C | PRO371 | |
C | GLY442 | |
C | LEU465 | |
C | VAL484 | |
C | HIS472 | |
D | GLY172 | |
D | LYS192 | |
D | PHE208 | |
A | GLY213 | |
D | GLY213 | |
D | GLU281 | |
D | ILE316 | |
D | GLN348 | |
D | PRO371 | |
D | GLY442 | |
D | LEU465 | |
D | VAL484 | |
D | HIS472 | |
E | GLY172 | |
A | GLU281 | |
E | LYS192 | |
E | PHE208 | |
E | GLY213 | |
E | GLU281 | |
E | ILE316 | |
E | GLN348 | |
E | PRO371 | |
E | GLY442 | |
E | LEU465 | |
E | VAL484 | |
A | ILE316 | |
E | HIS472 | |
F | GLY172 | |
F | LYS192 | |
F | PHE208 | |
F | GLY213 | |
F | GLU281 | |
F | ILE316 | |
F | GLN348 | |
F | PRO371 | |
F | GLY442 | |
A | GLN348 | |
F | LEU465 | |
F | VAL484 | |
F | HIS472 | |
A | PRO371 | |
A | GLY442 |
site_id | SWS_FT_FI3 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0007744|PDB:2J3N |
Chain | Residue | Details |
A | GLU311 | |
E | SER491 | |
F | GLU311 | |
F | SER491 | |
A | SER491 | |
B | GLU311 | |
B | SER491 | |
C | GLU311 | |
C | SER491 | |
D | GLU311 | |
D | SER491 | |
E | GLU311 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0007744|PDB:2ZZ0, ECO:0007744|PDB:2ZZB, ECO:0007744|PDB:3QFA |
Chain | Residue | Details |
A | GLY350 | |
B | GLY350 | |
C | GLY350 | |
D | GLY350 | |
E | GLY350 | |
F | GLY350 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:O89049 |
Chain | Residue | Details |
A | THR376 | |
B | THR376 | |
C | THR376 | |
D | THR376 | |
E | THR376 | |
F | THR376 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9JMH6 |
Chain | Residue | Details |
A | VAL218 | |
B | VAL218 | |
C | VAL218 | |
D | VAL218 | |
E | VAL218 | |
F | VAL218 |
site_id | SWS_FT_FI7 |
Number of Residues | 6 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
Chain | Residue | Details |
A | GLU281 | |
B | GLU281 | |
C | GLU281 | |
D | GLU281 | |
E | GLU281 | |
F | GLU281 |
site_id | SWS_FT_FI8 |
Number of Residues | 12 |
Details | CROSSLNK: Cysteinyl-selenocysteine (Cys-Sec) => ECO:0000250 |
Chain | Residue | Details |
A | CYS497 | |
E | CYS498 | |
F | CYS497 | |
F | CYS498 | |
A | CYS498 | |
B | CYS497 | |
B | CYS498 | |
C | CYS497 | |
C | CYS498 | |
D | CYS497 | |
D | CYS498 | |
E | CYS497 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
A | HIS472 | |
A | GLU477 | |
B | CYS64 | |
B | CYS59 |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
A | CYS64 | |
A | CYS59 | |
B | HIS472 | |
B | GLU477 |
site_id | CSA3 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
D | CYS64 | |
D | CYS59 | |
C | HIS472 | |
C | GLU477 |
site_id | CSA4 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
D | HIS472 | |
D | GLU477 | |
C | CYS64 | |
C | CYS59 |
site_id | CSA5 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
F | CYS64 | |
F | CYS59 | |
E | HIS472 | |
E | GLU477 |
site_id | CSA6 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
F | HIS472 | |
F | GLU477 | |
E | CYS64 | |
E | CYS59 |
site_id | CSA7 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
A | ASP181 | |
A | CYS177 | |
A | SER180 |
site_id | CSA8 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
B | ASP181 | |
B | CYS177 | |
B | SER180 |
site_id | CSA9 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
C | ASP181 | |
C | CYS177 | |
C | SER180 |
site_id | CSA10 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
D | ASP181 | |
D | CYS177 | |
D | SER180 |
site_id | CSA11 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
E | ASP181 | |
E | CYS177 | |
E | SER180 |
site_id | CSA12 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
F | ASP181 | |
F | CYS177 | |
F | SER180 |