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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

2J0Q

The crystal structure of the Exon Junction Complex at 3.2 A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
A0000398biological_processmRNA splicing, via spliceosome
A0003676molecular_functionnucleic acid binding
A0003723molecular_functionRNA binding
A0003724molecular_functionRNA helicase activity
A0003729molecular_functionmRNA binding
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005681cellular_componentspliceosomal complex
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006364biological_processrRNA processing
A0006397biological_processmRNA processing
A0006406biological_processmRNA export from nucleus
A0006417biological_processregulation of translation
A0008143molecular_functionpoly(A) binding
A0008306biological_processassociative learning
A0008380biological_processRNA splicing
A0010629biological_processnegative regulation of gene expression
A0016020cellular_componentmembrane
A0016607cellular_componentnuclear speck
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0017148biological_processnegative regulation of translation
A0030425cellular_componentdendrite
A0035145cellular_componentexon-exon junction complex
A0035368molecular_functionselenocysteine insertion sequence binding
A0035613molecular_functionRNA stem-loop binding
A0035640biological_processexploration behavior
A0043021molecular_functionribonucleoprotein complex binding
A0043025cellular_componentneuronal cell body
A0045727biological_processpositive regulation of translation
A0048701biological_processembryonic cranial skeleton morphogenesis
A0051028biological_processmRNA transport
A0071006cellular_componentU2-type catalytic step 1 spliceosome
A0071013cellular_componentcatalytic step 2 spliceosome
A0072715biological_processcellular response to selenite ion
A0090394biological_processnegative regulation of excitatory postsynaptic potential
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
A1904570biological_processnegative regulation of selenocysteine incorporation
A1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
A1990904cellular_componentribonucleoprotein complex
A2000622biological_processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
B0000166molecular_functionnucleotide binding
B0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
B0000398biological_processmRNA splicing, via spliceosome
B0003676molecular_functionnucleic acid binding
B0003723molecular_functionRNA binding
B0003724molecular_functionRNA helicase activity
B0003729molecular_functionmRNA binding
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005681cellular_componentspliceosomal complex
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006364biological_processrRNA processing
B0006397biological_processmRNA processing
B0006406biological_processmRNA export from nucleus
B0006417biological_processregulation of translation
B0008143molecular_functionpoly(A) binding
B0008306biological_processassociative learning
B0008380biological_processRNA splicing
B0010629biological_processnegative regulation of gene expression
B0016020cellular_componentmembrane
B0016607cellular_componentnuclear speck
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0017148biological_processnegative regulation of translation
B0030425cellular_componentdendrite
B0035145cellular_componentexon-exon junction complex
B0035368molecular_functionselenocysteine insertion sequence binding
B0035613molecular_functionRNA stem-loop binding
B0035640biological_processexploration behavior
B0043021molecular_functionribonucleoprotein complex binding
B0043025cellular_componentneuronal cell body
B0045727biological_processpositive regulation of translation
B0048701biological_processembryonic cranial skeleton morphogenesis
B0051028biological_processmRNA transport
B0071006cellular_componentU2-type catalytic step 1 spliceosome
B0071013cellular_componentcatalytic step 2 spliceosome
B0072715biological_processcellular response to selenite ion
B0090394biological_processnegative regulation of excitatory postsynaptic potential
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
B1904570biological_processnegative regulation of selenocysteine incorporation
B1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
B1990904cellular_componentribonucleoprotein complex
B2000622biological_processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
C0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
C0000381biological_processregulation of alternative mRNA splicing, via spliceosome
C0000398biological_processmRNA splicing, via spliceosome
C0003723molecular_functionRNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005681cellular_componentspliceosomal complex
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006397biological_processmRNA processing
C0006406biological_processmRNA export from nucleus
C0006417biological_processregulation of translation
C0008380biological_processRNA splicing
C0016607cellular_componentnuclear speck
C0035145cellular_componentexon-exon junction complex
C0050684biological_processregulation of mRNA processing
C0051028biological_processmRNA transport
C0071013cellular_componentcatalytic step 2 spliceosome
C1990501cellular_componentexon-exon junction subcomplex mago-y14
C2000622biological_processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
D0003676molecular_functionnucleic acid binding
D0003723molecular_functionRNA binding
D0003729molecular_functionmRNA binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0006396biological_processRNA processing
F0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
F0000381biological_processregulation of alternative mRNA splicing, via spliceosome
F0000398biological_processmRNA splicing, via spliceosome
F0003723molecular_functionRNA binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005681cellular_componentspliceosomal complex
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006397biological_processmRNA processing
F0006406biological_processmRNA export from nucleus
F0006417biological_processregulation of translation
F0008380biological_processRNA splicing
F0016607cellular_componentnuclear speck
F0035145cellular_componentexon-exon junction complex
F0050684biological_processregulation of mRNA processing
F0051028biological_processmRNA transport
F0071013cellular_componentcatalytic step 2 spliceosome
F1990501cellular_componentexon-exon junction subcomplex mago-y14
F2000622biological_processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
G0003676molecular_functionnucleic acid binding
G0003723molecular_functionRNA binding
G0003729molecular_functionmRNA binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0006396biological_processRNA processing
I0003723molecular_functionRNA binding
I0003729molecular_functionmRNA binding
I0006397biological_processmRNA processing
I0035145cellular_componentexon-exon junction complex
T0003723molecular_functionRNA binding
T0003729molecular_functionmRNA binding
T0006397biological_processmRNA processing
T0035145cellular_componentexon-exon junction complex
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 1412
ChainResidue
ATHR89
AASP187
AGLU188
AGLY340
AANP1413
site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG B 1412
ChainResidue
BTHR89
BASP187
BGLU188
BANP1413
site_idAC3
Number of Residues16
DetailsBINDING SITE FOR RESIDUE ANP A 1413
ChainResidue
APHE58
ALYS60
AGLN65
ASER84
AGLY85
AGLY87
ALYS88
ATHR89
AALA90
AGLU188
AGLY340
AASP342
AARG367
AARG370
ATYR371
AMG1412
site_idAC4
Number of Residues17
DetailsBINDING SITE FOR RESIDUE ANP B 1413
ChainResidue
BPHE58
BLYS60
BGLN65
BSER84
BGLY85
BTHR86
BGLY87
BLYS88
BTHR89
BALA90
BGLU188
BGLY340
BASP342
BARG367
BARG370
BTYR371
BMG1412
Functional Information from PROSITE/UniProt
site_idPS00039
Number of Residues9
DetailsDEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADEmL
ChainResidueDetails
AVAL185-LEU193
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues340
DetailsDomain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues322
DetailsDomain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues56
DetailsMotif: {"description":"Q motif"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues6
DetailsMotif: {"description":"DEAD box","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16923391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16931718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19033377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20479275","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EX7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P60842","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P60843","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"P60842","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues6
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues156
DetailsDomain: {"description":"RRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-10-22

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