2IXI

RmlC P aeruginosa with dTDP-xylose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000271	biological_process	polysaccharide biosynthetic process
A	0005829	cellular_component	cytosol
A	0008830	molecular_function	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A	0009103	biological_process	lipopolysaccharide biosynthetic process
A	0009244	biological_process	lipopolysaccharide core region biosynthetic process
A	0016853	molecular_function	isomerase activity
A	0019305	biological_process	dTDP-rhamnose biosynthetic process
B	0000271	biological_process	polysaccharide biosynthetic process
B	0005829	cellular_component	cytosol
B	0008830	molecular_function	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B	0009103	biological_process	lipopolysaccharide biosynthetic process
B	0009244	biological_process	lipopolysaccharide core region biosynthetic process
B	0016853	molecular_function	isomerase activity
B	0019305	biological_process	dTDP-rhamnose biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE TYD A1182

Chain	Residue
A	GLN47
A	HOH2229
B	PHE19
B	ARG23
B	PHE26
B	GLU28
A	TRP137
A	LYS167
A	HOH2223
A	HOH2224
A	HOH2225
A	HOH2226
A	HOH2227
A	HOH2228

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SRT A1183

Chain	Residue
A	HIS62
A	LYS71
A	HIS118
A	TYR131
A	HOH2126

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE TYD B1182

Chain	Residue
A	PHE19
A	ARG23
A	PHE26
A	GLU28
A	HOH2063
B	GLN47
B	TRP137
B	LYS167
B	HOH2183
B	HOH2200
B	HOH2219
B	HOH2220
B	HOH2222
B	HOH2223
B	HOH2225

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2IXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2IXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2003","submissionDatabase":"PDB data bank","title":"RmlC (dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase) crystal structure from Pseudomonas aeruginosa, apo structure.","authors":["Dong C.J.","Naismith J.H."]}},{"source":"PDB","id":"1RTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2003","submissionDatabase":"PDB data bank","title":"RmlC (dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase) crystal structure from Pseudomonas aeruginosa, apo structure.","authors":["Dong C.J.","Naismith J.H."]}},{"source":"PDB","id":"1RTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2003","submissionDatabase":"PDB data bank","title":"RmlC (dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase) crystal structure from Pseudomonas aeruginosa, apo structure.","authors":["Dong C.J.","Naismith J.H."]}},{"source":"PDB","id":"1RTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17046787","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2IXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IXK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Site: {"description":"Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose","evidences":[{"source":"UniProtKB","id":"Q5SFD1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1dzr

Chain	Residue	Details
A	HIS62
A	ASP168

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1dzr

Chain	Residue	Details
B	HIS62
B	ASP168

---

site_id	MCSA1
Number of Residues	4
Details	M-CSA 329

Chain	Residue	Details
A	HIS62	proton acceptor, proton donor
A	LYS71	electrostatic stabiliser
A	TYR131	proton acceptor, proton donor, proton relay
A	ASP168	electrostatic stabiliser, increase acidity, increase basicity

---

site_id	MCSA2
Number of Residues	4
Details	M-CSA 329

Chain	Residue	Details
B	HIS62	proton acceptor, proton donor
B	LYS71	electrostatic stabiliser
B	TYR131	proton acceptor, proton donor, proton relay
B	ASP168	electrostatic stabiliser, increase acidity, increase basicity

---