2IXI
RmlC P aeruginosa with dTDP-xylose
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0008830 | molecular_function | dTDP-4-dehydrorhamnose 3,5-epimerase activity |
| A | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| A | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| A | 0045226 | biological_process | extracellular polysaccharide biosynthetic process |
| B | 0005829 | cellular_component | cytosol |
| B | 0008830 | molecular_function | dTDP-4-dehydrorhamnose 3,5-epimerase activity |
| B | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| B | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| B | 0045226 | biological_process | extracellular polysaccharide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TYD A1182 |
| Chain | Residue |
| A | GLN47 |
| A | HOH2229 |
| B | PHE19 |
| B | ARG23 |
| B | PHE26 |
| B | GLU28 |
| A | TRP137 |
| A | LYS167 |
| A | HOH2223 |
| A | HOH2224 |
| A | HOH2225 |
| A | HOH2226 |
| A | HOH2227 |
| A | HOH2228 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SRT A1183 |
| Chain | Residue |
| A | HIS62 |
| A | LYS71 |
| A | HIS118 |
| A | TYR131 |
| A | HOH2126 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TYD B1182 |
| Chain | Residue |
| A | PHE19 |
| A | ARG23 |
| A | PHE26 |
| A | GLU28 |
| A | HOH2063 |
| B | GLN47 |
| B | TRP137 |
| B | LYS167 |
| B | HOH2183 |
| B | HOH2200 |
| B | HOH2219 |
| B | HOH2220 |
| B | HOH2222 |
| B | HOH2223 |
| B | HOH2225 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:17046787 |
| Chain | Residue | Details |
| A | HIS62 | |
| B | HIS62 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:17046787 |
| Chain | Residue | Details |
| A | TYR131 | |
| B | TYR131 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0007744|PDB:2IXI, ECO:0007744|PDB:2IXK |
| Chain | Residue | Details |
| A | ARG23 | |
| A | GLU28 | |
| B | ARG23 | |
| B | GLU28 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:17046787, ECO:0007744|PDB:2IXH |
| Chain | Residue | Details |
| A | GLN47 | |
| B | GLN47 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0000269|Ref.3, ECO:0007744|PDB:1RTV, ECO:0007744|PDB:2IXH, ECO:0007744|PDB:2IXJ, ECO:0007744|PDB:2IXK |
| Chain | Residue | Details |
| A | ARG59 | |
| B | ARG59 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0000269|Ref.3, ECO:0007744|PDB:1RTV, ECO:0007744|PDB:2IXH, ECO:0007744|PDB:2IXI, ECO:0007744|PDB:2IXJ, ECO:0007744|PDB:2IXK |
| Chain | Residue | Details |
| A | LYS71 | |
| A | HIS118 | |
| B | LYS71 | |
| B | HIS118 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0000269|Ref.3, ECO:0007744|PDB:1RTV, ECO:0007744|PDB:2IXJ |
| Chain | Residue | Details |
| A | GLU142 | |
| B | GLU142 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17046787, ECO:0007744|PDB:2IXH, ECO:0007744|PDB:2IXK |
| Chain | Residue | Details |
| A | LYS167 | |
| B | LYS167 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | SITE: Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose => ECO:0000250|UniProtKB:Q5SFD1 |
| Chain | Residue | Details |
| A | TRP137 | |
| B | TRP137 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dzr |
| Chain | Residue | Details |
| A | HIS62 | |
| A | ASP168 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dzr |
| Chain | Residue | Details |
| B | HIS62 | |
| B | ASP168 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 329 |
| Chain | Residue | Details |
| A | HIS62 | proton acceptor, proton donor |
| A | LYS71 | electrostatic stabiliser |
| A | TYR131 | proton acceptor, proton donor, proton relay |
| A | ASP168 | electrostatic stabiliser, increase acidity, increase basicity |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 329 |
| Chain | Residue | Details |
| B | HIS62 | proton acceptor, proton donor |
| B | LYS71 | electrostatic stabiliser |
| B | TYR131 | proton acceptor, proton donor, proton relay |
| B | ASP168 | electrostatic stabiliser, increase acidity, increase basicity |
