2IX6

SHORT CHAIN SPECIFIC ACYL-COA OXIDASE FROM ARABIDOPSIS THALIANA, ACX4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003995	molecular_function	acyl-CoA dehydrogenase activity
A	0003997	molecular_function	acyl-CoA oxidase activity
A	0005777	cellular_component	peroxisome
A	0005829	cellular_component	cytosol
A	0006631	biological_process	fatty acid metabolic process
A	0006635	biological_process	fatty acid beta-oxidation
A	0009514	cellular_component	glyoxysome
A	0009793	biological_process	embryo development ending in seed dormancy
A	0016491	molecular_function	oxidoreductase activity
A	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
A	0046459	biological_process	short-chain fatty acid metabolic process
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	1901149	molecular_function	salicylic acid binding
B	0003995	molecular_function	acyl-CoA dehydrogenase activity
B	0003997	molecular_function	acyl-CoA oxidase activity
B	0005777	cellular_component	peroxisome
B	0005829	cellular_component	cytosol
B	0006631	biological_process	fatty acid metabolic process
B	0006635	biological_process	fatty acid beta-oxidation
B	0009514	cellular_component	glyoxysome
B	0009793	biological_process	embryo development ending in seed dormancy
B	0016491	molecular_function	oxidoreductase activity
B	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
B	0046459	biological_process	short-chain fatty acid metabolic process
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	1901149	molecular_function	salicylic acid binding
C	0003995	molecular_function	acyl-CoA dehydrogenase activity
C	0003997	molecular_function	acyl-CoA oxidase activity
C	0005777	cellular_component	peroxisome
C	0005829	cellular_component	cytosol
C	0006631	biological_process	fatty acid metabolic process
C	0006635	biological_process	fatty acid beta-oxidation
C	0009514	cellular_component	glyoxysome
C	0009793	biological_process	embryo development ending in seed dormancy
C	0016491	molecular_function	oxidoreductase activity
C	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
C	0046459	biological_process	short-chain fatty acid metabolic process
C	0050660	molecular_function	flavin adenine dinucleotide binding
C	1901149	molecular_function	salicylic acid binding
D	0003995	molecular_function	acyl-CoA dehydrogenase activity
D	0003997	molecular_function	acyl-CoA oxidase activity
D	0005777	cellular_component	peroxisome
D	0005829	cellular_component	cytosol
D	0006631	biological_process	fatty acid metabolic process
D	0006635	biological_process	fatty acid beta-oxidation
D	0009514	cellular_component	glyoxysome
D	0009793	biological_process	embryo development ending in seed dormancy
D	0016491	molecular_function	oxidoreductase activity
D	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
D	0046459	biological_process	short-chain fatty acid metabolic process
D	0050660	molecular_function	flavin adenine dinucleotide binding
D	1901149	molecular_function	salicylic acid binding
E	0003995	molecular_function	acyl-CoA dehydrogenase activity
E	0003997	molecular_function	acyl-CoA oxidase activity
E	0005777	cellular_component	peroxisome
E	0005829	cellular_component	cytosol
E	0006631	biological_process	fatty acid metabolic process
E	0006635	biological_process	fatty acid beta-oxidation
E	0009514	cellular_component	glyoxysome
E	0009793	biological_process	embryo development ending in seed dormancy
E	0016491	molecular_function	oxidoreductase activity
E	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
E	0046459	biological_process	short-chain fatty acid metabolic process
E	0050660	molecular_function	flavin adenine dinucleotide binding
E	1901149	molecular_function	salicylic acid binding
F	0003995	molecular_function	acyl-CoA dehydrogenase activity
F	0003997	molecular_function	acyl-CoA oxidase activity
F	0005777	cellular_component	peroxisome
F	0005829	cellular_component	cytosol
F	0006631	biological_process	fatty acid metabolic process
F	0006635	biological_process	fatty acid beta-oxidation
F	0009514	cellular_component	glyoxysome
F	0009793	biological_process	embryo development ending in seed dormancy
F	0016491	molecular_function	oxidoreductase activity
F	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
F	0046459	biological_process	short-chain fatty acid metabolic process
F	0050660	molecular_function	flavin adenine dinucleotide binding
F	1901149	molecular_function	salicylic acid binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE FAD A 800

Chain	Residue
A	TRP172
A	TYR407
A	THR410
A	ASP412
A	PHE428
C	ARG313
C	PHE316
C	LEU320
C	PHE323
C	ASN326
C	GLU381
A	LEU174
C	LEU382
C	GLY385
A	THR175
A	GLY180
A	SER181
A	TRP205
A	GLY207
A	ASN255
A	GLN324

---

site_id	AC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE FAD B 800

Chain	Residue
B	TRP172
B	LEU174
B	THR175
B	GLY180
B	SER181
B	TRP205
B	GLY207
B	ASN255
B	TYR407
B	THR410
B	ASP412
B	PHE428
D	GLN324
E	ARG313
E	PHE316
E	PHE323
E	ASN326
E	GLU381
E	LEU382
E	GLY385

---

site_id	AC3
Number of Residues	23
Details	BINDING SITE FOR RESIDUE FAD C 800

Chain	Residue
A	ARG313
A	PHE316
A	LEU320
A	PHE323
A	ASN326
A	GLU381
A	LEU382
A	GLY385
A	ILE388
C	TRP172
C	LEU174
C	THR175
C	GLY180
C	SER181
C	TRP205
C	GLY207
C	ASN255
C	GLN324
C	PRO403
C	TYR407
C	THR410
C	ASP412
C	PHE428

---

site_id	AC4
Number of Residues	22
Details	BINDING SITE FOR RESIDUE FAD D 800

Chain	Residue
B	GLN324
D	TRP172
D	LEU174
D	THR175
D	GLY180
D	SER181
D	TRP205
D	GLY207
D	ASN255
D	PRO403
D	TYR407
D	THR410
D	ASP412
D	PHE428
F	ARG313
F	PHE316
F	LEU320
F	PHE323
F	ASN326
F	GLU381
F	LEU382
F	GLY385

---

site_id	AC5
Number of Residues	21
Details	BINDING SITE FOR RESIDUE FAD E 800

Chain	Residue
E	GLY207
E	ASN255
E	PRO403
E	TYR407
E	THR410
E	ASP412
E	PHE428
F	GLN324
B	ARG313
B	PHE316
B	PHE323
B	ASN326
B	GLU381
B	LEU382
B	GLY385
E	TRP172
E	LEU174
E	THR175
E	GLY180
E	SER181
E	TRP205

---

site_id	AC6
Number of Residues	22
Details	BINDING SITE FOR RESIDUE FAD F 800

Chain	Residue
D	ARG313
D	GLN315
D	PHE316
D	LEU320
D	PHE323
D	ASN326
D	GLU381
D	LEU382
D	GLY385
E	GLN324
F	TRP172
F	LEU174
F	THR175
F	GLY180
F	SER181
F	TRP205
F	GLY207
F	ASN255
F	TYR407
F	THR410
F	ASP412
F	PHE428

---

Functional Information from PROSITE/UniProt

site_id	PS00072
Number of Residues	13
Details	ACYL_COA_DH_1 Acyl-CoA dehydrogenases signature 1. ALTEpdNGSDasG

Chain	Residue	Details
A	ALA173-GLY185

---

site_id	PS00073
Number of Residues	20
Details	ACYL_COA_DH_2 Acyl-CoA dehydrogenases signature 2. ElLGGnGIlaDflvaKafcD

Chain	Residue	Details
A	GLU381-ASP400

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	BINDING: BINDING => ECO:0000269|PubMed:16887802, ECO:0007744|PDB:2IX5, ECO:0007744|PDB:2IX6

Chain	Residue	Details
C	GLY385
C	THR410
C	PHE428
D	TRP172
D	SER181
D	ARG313
D	GLU381
D	GLY385
D	THR410
D	PHE428
E	TRP172
E	SER181
E	ARG313
E	GLU381
E	GLY385
E	THR410
E	PHE428
F	TRP172
F	SER181
F	ARG313
F	GLU381
F	GLY385
F	THR410
F	PHE428
A	TRP172
A	SER181
A	ARG313
A	GLU381
A	GLY385
A	THR410
A	PHE428
B	TRP172
B	SER181
B	ARG313
B	GLU381
B	GLY385
B	THR410
B	PHE428
C	TRP172
C	SER181
C	ARG313
C	GLU381

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:16887802, ECO:0007744|PDB:2IX5

Chain	Residue	Details
B	GLN324
B	GLY409
C	GLY207
C	ARG288
C	GLN324
C	GLY409
D	GLY207
D	ARG288
D	GLN324
D	GLY409
E	GLY207
E	ARG288
E	GLN324
E	GLY409
F	GLY207
F	ARG288
F	GLN324
F	GLY409
A	GLY207
A	ARG288
A	GLN324
A	GLY409
B	GLY207
B	ARG288

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22223895

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2
D	ALA2
E	ALA2
F	ALA2

---