2IWY

Human mitochondrial beta-ketoacyl ACP synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006637	biological_process	acyl-CoA metabolic process
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0032787	biological_process	monocarboxylic acid metabolic process
A	0051790	biological_process	short-chain fatty acid biosynthetic process
A	0051792	biological_process	medium-chain fatty acid biosynthetic process
B	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0006637	biological_process	acyl-CoA metabolic process
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0032787	biological_process	monocarboxylic acid metabolic process
B	0051790	biological_process	short-chain fatty acid biosynthetic process
B	0051792	biological_process	medium-chain fatty acid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NH4 A1460

Chain	Residue
A	ASN346
A	ALA347
A	GLU394
A	THR442
A	ASN443

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NH4 B1460

Chain	Residue
B	ASN443
B	ASN346
B	ALA347
B	GLU394
B	THR442

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Functional Information from PROSITE/UniProt

site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPNhaVStACTTGahAV

Chain	Residue	Details
A	GLY200-VAL216

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site_id	PS00107
Number of Residues	31
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGYGLSGDAGhItapdpegegalrcma...AALK

Chain	Residue	Details
A	LEU303-LYS333

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348

Chain	Residue	Details
A	CYS209
A	HIS348
A	HIS385
B	CYS209
B	HIS348
B	HIS385

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9D404

Chain	Residue	Details
A	LYS109
A	LYS174
B	LYS109
B	LYS174

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9D404

Chain	Residue	Details
A	LYS113
B	LYS113

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