2IU9
Chlamydia trachomatis LpxD with 100mM UDPGlcNAc (Complex II)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0009245 | biological_process | lipid A biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016410 | molecular_function | N-acyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0103118 | molecular_function | UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0009245 | biological_process | lipid A biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016410 | molecular_function | N-acyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0103118 | molecular_function | UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0009245 | biological_process | lipid A biosynthetic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016410 | molecular_function | N-acyltransferase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0103118 | molecular_function | UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A1348 |
| Chain | Residue |
| A | SER64 |
| A | ARG65 |
| A | THR66 |
| A | THR81 |
| A | SER82 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A1349 |
| Chain | Residue |
| C | LEU242 |
| C | GLN260 |
| A | LEU242 |
| A | GLN260 |
| B | LEU242 |
| B | GLN260 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B1346 |
| Chain | Residue |
| A | GLN20 |
| A | ARG72 |
| B | SER64 |
| B | ARG65 |
| B | THR66 |
| B | THR81 |
| B | SER82 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C1349 |
| Chain | Residue |
| C | ARG65 |
| C | SER82 |
| C | HOH2004 |
| C | HOH2020 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C1350 |
| Chain | Residue |
| A | HIS162 |
| A | GLN180 |
| C | ARG168 |
| C | CYS188 |
| C | HIS202 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B1351 |
| Chain | Residue |
| B | PHE14 |
| B | HOH2031 |
| B | HOH2032 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BME A1347 |
| Chain | Residue |
| A | ARG168 |
| A | CYS188 |
| A | HIS202 |
| B | HIS162 |
| B | GLN180 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PLM A1350 |
| Chain | Residue |
| A | GLN244 |
| A | ALA246 |
| A | GLY262 |
| A | ILE263 |
| A | ALA264 |
| A | GLY280 |
| A | ILE281 |
| A | THR282 |
| A | VAL299 |
| A | THR300 |
| B | ASP240 |
| B | ALA295 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE UD1 B1347 |
| Chain | Residue |
| A | HIS247 |
| A | GLN248 |
| A | HIS284 |
| B | GLU32 |
| B | ILE33 |
| B | GLU34 |
| B | PHE43 |
| B | LEU44 |
| B | ASP45 |
| B | ASN46 |
| B | TYR49 |
| site_id | BC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PLM B1348 |
| Chain | Residue |
| B | GLN244 |
| B | ALA246 |
| B | GLY262 |
| B | ILE263 |
| B | ALA264 |
| B | GLY280 |
| B | ILE281 |
| B | GLY298 |
| B | THR300 |
| C | ASP240 |
| C | VAL258 |
| C | ALA259 |
| C | ALA295 |
| C | GLN296 |
| site_id | BC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE UD1 C1351 |
| Chain | Residue |
| B | TYR192 |
| B | HIS247 |
| B | GLN248 |
| B | GLY265 |
| B | GLY283 |
| B | HIS284 |
| C | GLU32 |
| C | ILE33 |
| C | GLU34 |
| C | THR42 |
| C | PHE43 |
| C | LEU44 |
| C | ASP45 |
| C | TYR49 |
| site_id | BC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PLM C1352 |
| Chain | Residue |
| A | ASP240 |
| A | VAL258 |
| A | ALA259 |
| A | MET294 |
| A | ALA295 |
| C | GLN244 |
| C | ALA246 |
| C | GLY262 |
| C | ILE263 |
| C | ALA264 |
| C | ILE281 |
| C | THR282 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17360522","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 15 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17360522","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Site: {"description":"Participates in a stacking interaction with the uracil ring of UDP-GlcNAc"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1lxa |
| Chain | Residue | Details |
| A | HIS247 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1lxa |
| Chain | Residue | Details |
| B | HIS247 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1lxa |
| Chain | Residue | Details |
| C | HIS247 |
