2ISW

Structure of Giardia fructose-1,6-biphosphate aldolase in complex with phosphoglycolohydroxamate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004332	molecular_function	fructose-bisphosphate aldolase activity
A	0005515	molecular_function	protein binding
A	0005975	biological_process	carbohydrate metabolic process
A	0006096	biological_process	glycolytic process
A	0008270	molecular_function	zinc ion binding
A	0016829	molecular_function	lyase activity
A	0016832	molecular_function	aldehyde-lyase activity
A	0046872	molecular_function	metal ion binding
B	0004332	molecular_function	fructose-bisphosphate aldolase activity
B	0005515	molecular_function	protein binding
B	0005975	biological_process	carbohydrate metabolic process
B	0006096	biological_process	glycolytic process
B	0008270	molecular_function	zinc ion binding
B	0016829	molecular_function	lyase activity
B	0016832	molecular_function	aldehyde-lyase activity
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 326

Chain	Residue
A	HIS84
A	HIS178
A	HIS210
A	PGH325

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site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PGH A 325

Chain	Residue
A	LYS182
A	HIS210
A	GLY211
A	SER212
A	SER213
A	ASN253
A	ASP255
A	SER256
A	ZN326
A	HOH466
A	ASN24
A	GLN48
A	ASP83
A	HIS178
A	GLY179

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Functional Information from PROSITE/UniProt

site_id	PS00806
Number of Residues	12
Details	ALDOLASE_CLASS_II_2 Fructose-bisphosphate aldolase class-II signature 2. VEaELGtlGGiE

Chain	Residue	Details
A	VAL132-GLU143

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000269|PubMed:19236002, ECO:0000305|PubMed:17166851

Chain	Residue	Details
A	ASP83
B	ASP83

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site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269|PubMed:19236002, ECO:0007744|PDB:3GAY, ECO:0007744|PDB:3GB6

Chain	Residue	Details
A	SER50
A	ARG280
B	SER50
B	GLY179
B	LYS182
B	GLY211
B	SER213
B	ASN253
B	ASP255
B	SER256
B	ARG259
A	GLY179
B	ARG280
A	LYS182
A	GLY211
A	SER213
A	ASN253
A	ASP255
A	SER256
A	ARG259

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:17166851, ECO:0000269|PubMed:19236002, ECO:0000269|PubMed:21333622, ECO:0007744|PDB:2ISV, ECO:0007744|PDB:2ISW, ECO:0007744|PDB:3GAK, ECO:0007744|PDB:3GAY, ECO:0007744|PDB:3GB6, ECO:0007744|PDB:3OHI

Chain	Residue	Details
A	HIS84
A	HIS178
A	HIS210
B	HIS84
B	HIS178
B	HIS210

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1b57

Chain	Residue	Details
A	ASP83
A	ASN253

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1b57

Chain	Residue	Details
B	ASP83
B	ASN253

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