2IS6
Crystal structure of UvrD-DNA-ADPMgF3 ternary complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000725 | biological_process | recombinational repair |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003678 | molecular_function | DNA helicase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006260 | biological_process | DNA replication |
| A | 0006289 | biological_process | nucleotide-excision repair |
| A | 0006298 | biological_process | mismatch repair |
| A | 0009314 | biological_process | response to radiation |
| A | 0009432 | biological_process | SOS response |
| A | 0015616 | molecular_function | DNA translocase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0017116 | molecular_function | single-stranded DNA helicase activity |
| A | 0017117 | cellular_component | single-stranded DNA-dependent ATP-dependent DNA helicase complex |
| A | 0031297 | biological_process | replication fork processing |
| A | 0033202 | cellular_component | DNA helicase complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043138 | molecular_function | 3'-5' DNA helicase activity |
| A | 0070581 | biological_process | rolling circle DNA replication |
| A | 0070716 | biological_process | mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication |
| B | 0000725 | biological_process | recombinational repair |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003678 | molecular_function | DNA helicase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006260 | biological_process | DNA replication |
| B | 0006289 | biological_process | nucleotide-excision repair |
| B | 0006298 | biological_process | mismatch repair |
| B | 0009314 | biological_process | response to radiation |
| B | 0009432 | biological_process | SOS response |
| B | 0015616 | molecular_function | DNA translocase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0017116 | molecular_function | single-stranded DNA helicase activity |
| B | 0017117 | cellular_component | single-stranded DNA-dependent ATP-dependent DNA helicase complex |
| B | 0031297 | biological_process | replication fork processing |
| B | 0033202 | cellular_component | DNA helicase complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0043138 | molecular_function | 3'-5' DNA helicase activity |
| B | 0070581 | biological_process | rolling circle DNA replication |
| B | 0070716 | biological_process | mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 681 |
| Chain | Residue |
| A | THR36 |
| A | MGF699 |
| A | ADP700 |
| A | HOH837 |
| A | HOH838 |
| A | HOH839 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 681 |
| Chain | Residue |
| B | HOH732 |
| B | HOH777 |
| B | HOH778 |
| B | THR36 |
| B | MGF701 |
| B | ADP702 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE MGF A 699 |
| Chain | Residue |
| A | ALA31 |
| A | GLY32 |
| A | LYS35 |
| A | GLU221 |
| A | GLN251 |
| A | ARG284 |
| A | GLY564 |
| A | ARG605 |
| A | MG681 |
| A | ADP700 |
| A | HOH702 |
| A | HOH748 |
| A | HOH837 |
| A | HOH838 |
| A | HOH839 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ADP A 700 |
| Chain | Residue |
| A | SER9 |
| A | GLN14 |
| A | GLY32 |
| A | SER33 |
| A | GLY34 |
| A | LYS35 |
| A | THR36 |
| A | ARG37 |
| A | ARG73 |
| A | TYR283 |
| A | ARG284 |
| A | GLU566 |
| A | MG681 |
| A | MGF699 |
| A | HOH770 |
| A | HOH773 |
| A | HOH805 |
| A | HOH806 |
| A | HOH838 |
| A | HOH839 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE MGF B 701 |
| Chain | Residue |
| B | ALA31 |
| B | GLY32 |
| B | LYS35 |
| B | GLU221 |
| B | GLN251 |
| B | ARG284 |
| B | GLY564 |
| B | ARG605 |
| B | MG681 |
| B | ADP702 |
| B | HOH703 |
| B | HOH732 |
| B | HOH752 |
| B | HOH777 |
| B | HOH778 |
| site_id | AC6 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ADP B 702 |
| Chain | Residue |
| B | SER9 |
| B | GLN14 |
| B | GLY32 |
| B | SER33 |
| B | GLY34 |
| B | LYS35 |
| B | THR36 |
| B | ARG37 |
| B | ARG73 |
| B | TYR283 |
| B | ARG284 |
| B | GLU566 |
| B | MG681 |
| B | MGF701 |
| B | HOH732 |
| B | HOH764 |
| B | HOH778 |
| B | HOH790 |
| B | HOH793 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 701 |
| Chain | Residue |
| A | GLN555 |
| A | GLU566 |
| A | PHE567 |
| A | HOH752 |
| A | HOH926 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 278 |
| Details | Domain: {"description":"UvrD-like helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00560","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00560","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qhg |
| Chain | Residue | Details |
| A | ARG605 | |
| A | GLU221 | |
| A | LYS35 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qhg |
| Chain | Residue | Details |
| B | ARG605 | |
| B | GLU221 | |
| B | LYS35 |
