Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2IS6

Crystal structure of UvrD-DNA-ADPMgF3 ternary complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000725	biological_process	recombinational repair
A	0003677	molecular_function	DNA binding
A	0003678	molecular_function	DNA helicase activity
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006289	biological_process	nucleotide-excision repair
A	0006298	biological_process	mismatch repair
A	0006974	biological_process	DNA damage response
A	0009314	biological_process	response to radiation
A	0009432	biological_process	SOS response
A	0015616	molecular_function	DNA translocase activity
A	0016787	molecular_function	hydrolase activity
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0017116	molecular_function	single-stranded DNA helicase activity
A	0017117	cellular_component	single-stranded DNA-dependent ATP-dependent DNA helicase complex
A	0031297	biological_process	replication fork processing
A	0033202	cellular_component	DNA helicase complex
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043138	molecular_function	3'-5' DNA helicase activity
A	0070581	biological_process	rolling circle DNA replication
A	0070716	biological_process	mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
B	0000166	molecular_function	nucleotide binding
B	0000725	biological_process	recombinational repair
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0006281	biological_process	DNA repair
B	0006289	biological_process	nucleotide-excision repair
B	0006298	biological_process	mismatch repair
B	0006974	biological_process	DNA damage response
B	0009314	biological_process	response to radiation
B	0009432	biological_process	SOS response
B	0015616	molecular_function	DNA translocase activity
B	0016787	molecular_function	hydrolase activity
B	0016853	molecular_function	isomerase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0017116	molecular_function	single-stranded DNA helicase activity
B	0017117	cellular_component	single-stranded DNA-dependent ATP-dependent DNA helicase complex
B	0031297	biological_process	replication fork processing
B	0033202	cellular_component	DNA helicase complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043138	molecular_function	3'-5' DNA helicase activity
B	0070581	biological_process	rolling circle DNA replication
B	0070716	biological_process	mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 681

Chain	Residue
A	THR36
A	MGF699
A	ADP700
A	HOH837
A	HOH838
A	HOH839

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 681

Chain	Residue
B	HOH732
B	HOH777
B	HOH778
B	THR36
B	MGF701
B	ADP702

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE MGF A 699

Chain	Residue
A	ALA31
A	GLY32
A	LYS35
A	GLU221
A	GLN251
A	ARG284
A	GLY564
A	ARG605
A	MG681
A	ADP700
A	HOH702
A	HOH748
A	HOH837
A	HOH838
A	HOH839

site_id	AC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP A 700

Chain	Residue
A	SER9
A	GLN14
A	GLY32
A	SER33
A	GLY34
A	LYS35
A	THR36
A	ARG37
A	ARG73
A	TYR283
A	ARG284
A	GLU566
A	MG681
A	MGF699
A	HOH770
A	HOH773
A	HOH805
A	HOH806
A	HOH838
A	HOH839

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE MGF B 701

Chain	Residue
B	ALA31
B	GLY32
B	LYS35
B	GLU221
B	GLN251
B	ARG284
B	GLY564
B	ARG605
B	MG681
B	ADP702
B	HOH703
B	HOH732
B	HOH752
B	HOH777
B	HOH778

site_id	AC6
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ADP B 702

Chain	Residue
B	SER9
B	GLN14
B	GLY32
B	SER33
B	GLY34
B	LYS35
B	THR36
B	ARG37
B	ARG73
B	TYR283
B	ARG284
B	GLU566
B	MG681
B	MGF701
B	HOH732
B	HOH764
B	HOH778
B	HOH790
B	HOH793

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 701

Chain	Residue
A	GLN555
A	GLU566
A	PHE567
A	HOH752
A	HOH926

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	278
Details	Domain: {"description":"UvrD-like helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00560","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00560","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1qhg

Chain	Residue	Details
A	ARG605
A	GLU221
A	LYS35

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1qhg

Chain	Residue	Details
B	ARG605
B	GLU221
B	LYS35

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)