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2IS6

Crystal structure of UvrD-DNA-ADPMgF3 ternary complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000717biological_processnucleotide-excision repair, DNA duplex unwinding
A0000725biological_processrecombinational repair
A0003677molecular_functionDNA binding
A0003678molecular_functionDNA helicase activity
A0003689molecular_functionDNA clamp loader activity
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006260biological_processDNA replication
A0006268biological_processDNA unwinding involved in DNA replication
A0006281biological_processDNA repair
A0006289biological_processnucleotide-excision repair
A0006298biological_processmismatch repair
A0006338biological_processchromatin remodeling
A0009314biological_processresponse to radiation
A0009378molecular_functionfour-way junction helicase activity
A0009432biological_processSOS response
A0015616molecular_functionDNA translocase activity
A0016787molecular_functionhydrolase activity
A0016853molecular_functionisomerase activity
A0016887molecular_functionATP hydrolysis activity
A0017116molecular_functionsingle-stranded DNA helicase activity
A0017117cellular_componentsingle-stranded DNA-dependent ATP-dependent DNA helicase complex
A0031297biological_processreplication fork processing
A0032508biological_processDNA duplex unwinding
A0033202cellular_componentDNA helicase complex
A0036121molecular_functiondouble-stranded DNA helicase activity
A0042803molecular_functionprotein homodimerization activity
A0043138molecular_function3'-5' DNA helicase activity
A0061749molecular_functionforked DNA-dependent helicase activity
A0061775molecular_functioncohesin loader activity
A0070581biological_processrolling circle DNA replication
A0070716biological_processmismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
A0140584molecular_functionchromatin extrusion motor activity
A0140588biological_processchromatin looping
A0140665molecular_functionATP-dependent H3-H4 histone complex chaperone activity
A0140849molecular_functionATP-dependent H2AZ histone chaperone activity
A1990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
B0000717biological_processnucleotide-excision repair, DNA duplex unwinding
B0000725biological_processrecombinational repair
B0003677molecular_functionDNA binding
B0003678molecular_functionDNA helicase activity
B0003689molecular_functionDNA clamp loader activity
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006260biological_processDNA replication
B0006268biological_processDNA unwinding involved in DNA replication
B0006281biological_processDNA repair
B0006289biological_processnucleotide-excision repair
B0006298biological_processmismatch repair
B0006338biological_processchromatin remodeling
B0009314biological_processresponse to radiation
B0009378molecular_functionfour-way junction helicase activity
B0009432biological_processSOS response
B0015616molecular_functionDNA translocase activity
B0016787molecular_functionhydrolase activity
B0016853molecular_functionisomerase activity
B0016887molecular_functionATP hydrolysis activity
B0017116molecular_functionsingle-stranded DNA helicase activity
B0017117cellular_componentsingle-stranded DNA-dependent ATP-dependent DNA helicase complex
B0031297biological_processreplication fork processing
B0032508biological_processDNA duplex unwinding
B0033202cellular_componentDNA helicase complex
B0036121molecular_functiondouble-stranded DNA helicase activity
B0042803molecular_functionprotein homodimerization activity
B0043138molecular_function3'-5' DNA helicase activity
B0061749molecular_functionforked DNA-dependent helicase activity
B0061775molecular_functioncohesin loader activity
B0070581biological_processrolling circle DNA replication
B0070716biological_processmismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
B0140584molecular_functionchromatin extrusion motor activity
B0140588biological_processchromatin looping
B0140665molecular_functionATP-dependent H3-H4 histone complex chaperone activity
B0140849molecular_functionATP-dependent H2AZ histone chaperone activity
B1990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 681
ChainResidue
ATHR36
AMGF699
AADP700
AHOH837
AHOH838
AHOH839

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG B 681
ChainResidue
BHOH732
BHOH777
BHOH778
BTHR36
BMGF701
BADP702

site_idAC3
Number of Residues15
DetailsBINDING SITE FOR RESIDUE MGF A 699
ChainResidue
AALA31
AGLY32
ALYS35
AGLU221
AGLN251
AARG284
AGLY564
AARG605
AMG681
AADP700
AHOH702
AHOH748
AHOH837
AHOH838
AHOH839

site_idAC4
Number of Residues20
DetailsBINDING SITE FOR RESIDUE ADP A 700
ChainResidue
ASER9
AGLN14
AGLY32
ASER33
AGLY34
ALYS35
ATHR36
AARG37
AARG73
ATYR283
AARG284
AGLU566
AMG681
AMGF699
AHOH770
AHOH773
AHOH805
AHOH806
AHOH838
AHOH839

site_idAC5
Number of Residues15
DetailsBINDING SITE FOR RESIDUE MGF B 701
ChainResidue
BALA31
BGLY32
BLYS35
BGLU221
BGLN251
BARG284
BGLY564
BARG605
BMG681
BADP702
BHOH703
BHOH732
BHOH752
BHOH777
BHOH778

site_idAC6
Number of Residues19
DetailsBINDING SITE FOR RESIDUE ADP B 702
ChainResidue
BSER9
BGLN14
BGLY32
BSER33
BGLY34
BLYS35
BTHR36
BARG37
BARG73
BTYR283
BARG284
BGLU566
BMG681
BMGF701
BHOH732
BHOH764
BHOH778
BHOH790
BHOH793

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 701
ChainResidue
AGLN555
AGLU566
APHE567
AHOH752
AHOH926

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00560
ChainResidueDetails
AGLY32
BGLY32

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AARG284
BARG284

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1qhg
ChainResidueDetails
AARG605
AGLU221
ALYS35

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1qhg
ChainResidueDetails
BARG605
BGLU221
BLYS35

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PDB entries from 2024-11-06

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