2IRF
CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| G | 0000976 | molecular_function | transcription cis-regulatory region binding |
| G | 0003700 | molecular_function | DNA-binding transcription factor activity |
| G | 0006355 | biological_process | regulation of DNA-templated transcription |
| H | 0000976 | molecular_function | transcription cis-regulatory region binding |
| H | 0003700 | molecular_function | DNA-binding transcription factor activity |
| H | 0006355 | biological_process | regulation of DNA-templated transcription |
| I | 0000976 | molecular_function | transcription cis-regulatory region binding |
| I | 0003700 | molecular_function | DNA-binding transcription factor activity |
| I | 0006355 | biological_process | regulation of DNA-templated transcription |
| J | 0000976 | molecular_function | transcription cis-regulatory region binding |
| J | 0003700 | molecular_function | DNA-binding transcription factor activity |
| J | 0006355 | biological_process | regulation of DNA-templated transcription |
| K | 0000976 | molecular_function | transcription cis-regulatory region binding |
| K | 0003700 | molecular_function | DNA-binding transcription factor activity |
| K | 0006355 | biological_process | regulation of DNA-templated transcription |
| L | 0000976 | molecular_function | transcription cis-regulatory region binding |
| L | 0003700 | molecular_function | DNA-binding transcription factor activity |
| L | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K G 4001 |
| Chain | Residue |
| G | MET85 |
| G | ASN86 |
| G | LEU88 |
| G | ILE91 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K L 4002 |
| Chain | Residue |
| L | MET2085 |
| L | ASN2086 |
| L | LEU2088 |
| L | ILE2091 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K I 4003 |
| Chain | Residue |
| I | ASN486 |
| I | LEU488 |
| I | ILE491 |
| I | MET485 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K K 4004 |
| Chain | Residue |
| K | MET885 |
| K | ASN886 |
| K | LEU888 |
| K | ILE891 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K J 4005 |
| Chain | Residue |
| J | MET685 |
| J | ASN686 |
| J | LEU688 |
| J | ILE691 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K H 4006 |
| Chain | Residue |
| H | MET285 |
| H | ASN286 |
| H | LEU288 |
| H | ILE291 |
Functional Information from PROSITE/UniProt
| site_id | PS00601 |
| Number of Residues | 34 |
| Details | IRF_1 IRF tryptophan pentad repeat DNA-binding domain signature. WlNkekkiFqIPWmHaarhgwdvekDapLFRnWA |
| Chain | Residue | Details |
| G | TRP26-ALA59 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 648 |
| Details | DNA_BIND: IRF tryptophan pentad repeat => ECO:0000255|PROSITE-ProRule:PRU00840 |
| Chain | Residue | Details |
| G | ARG5-PRO113 | |
| H | ARG205-PRO313 | |
| I | ARG405-PRO513 | |
| J | ARG605-PRO713 | |
| K | ARG805-PRO913 | |
| L | ARG2005-PRO2113 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P14316 |
| Chain | Residue | Details |
| G | LYS75 | |
| K | LYS878 | |
| L | LYS2075 | |
| L | LYS2078 | |
| G | LYS78 | |
| H | LYS275 | |
| H | LYS278 | |
| I | LYS475 | |
| I | LYS478 | |
| J | LYS675 | |
| J | LYS678 | |
| K | LYS875 |
