2IPO
E. coli Aspartate Transcarbamoylase complexed with N-phosphonacetyl-L-asparagine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
A | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0006520 | biological_process | amino acid metabolic process |
A | 0006541 | biological_process | glutamine metabolic process |
A | 0009347 | cellular_component | aspartate carbamoyltransferase complex |
A | 0016597 | molecular_function | amino acid binding |
A | 0016740 | molecular_function | transferase activity |
A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
A | 0070207 | biological_process | protein homotrimerization |
B | 0005515 | molecular_function | protein binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0008270 | molecular_function | zinc ion binding |
B | 0009347 | cellular_component | aspartate carbamoyltransferase complex |
B | 0046872 | molecular_function | metal ion binding |
C | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
C | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
C | 0005515 | molecular_function | protein binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
C | 0006520 | biological_process | amino acid metabolic process |
C | 0006541 | biological_process | glutamine metabolic process |
C | 0009347 | cellular_component | aspartate carbamoyltransferase complex |
C | 0016597 | molecular_function | amino acid binding |
C | 0016740 | molecular_function | transferase activity |
C | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
C | 0042802 | molecular_function | identical protein binding |
C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
C | 0070207 | biological_process | protein homotrimerization |
D | 0005515 | molecular_function | protein binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
D | 0008270 | molecular_function | zinc ion binding |
D | 0009347 | cellular_component | aspartate carbamoyltransferase complex |
D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 201 |
Chain | Residue |
B | CYS109 |
B | CYS114 |
B | CYS138 |
B | CYS141 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 201 |
Chain | Residue |
D | CYS109 |
D | CYS114 |
D | CYS138 |
D | CYS141 |
site_id | AC3 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE 1IP A 401 |
Chain | Residue |
A | THR53 |
A | ARG54 |
A | THR55 |
A | SER80 |
A | LYS84 |
A | ARG105 |
A | HIS134 |
A | GLN137 |
A | ARG167 |
A | THR168 |
A | ARG229 |
A | GLN231 |
A | LEU267 |
A | HOH408 |
A | HOH409 |
A | HOH436 |
A | HOH448 |
A | HOH507 |
A | SER52 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MAE C 411 |
Chain | Residue |
C | PRO3 |
C | LEU4 |
C | LYS7 |
C | ASP14 |
C | ASP19 |
site_id | AC5 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE 1IP C 401 |
Chain | Residue |
C | SER52 |
C | THR53 |
C | ARG54 |
C | THR55 |
C | SER80 |
C | LYS84 |
C | ARG105 |
C | HIS134 |
C | GLN137 |
C | ARG167 |
C | THR168 |
C | ARG229 |
C | GLN231 |
C | LEU267 |
C | MAE412 |
C | HOH419 |
C | HOH444 |
C | HOH446 |
site_id | AC6 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE MAE C 412 |
Chain | Residue |
C | ARG54 |
C | THR55 |
C | HIS134 |
C | GLN137 |
C | LEU140 |
C | PRO266 |
C | ALA289 |
C | ARG296 |
C | 1IP401 |
C | HOH441 |
C | HOH483 |
site_id | AC7 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE MPD A 402 |
Chain | Residue |
A | PHE48 |
A | GLU50 |
A | ALA51 |
A | SER52 |
A | ARG56 |
A | PHE73 |
A | SER74 |
A | ASN78 |
A | THR79 |
site_id | AC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MPD C 413 |
Chain | Residue |
C | LYS232 |
C | TYR240 |
Functional Information from PROSITE/UniProt
site_id | PS00097 |
Number of Residues | 8 |
Details | CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FfEaSTRT |
Chain | Residue | Details |
A | PHE48-THR55 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | BINDING: |
Chain | Residue | Details |
B | PRO110 | |
C | HIS106 | |
C | PRO135 | |
C | THR138 | |
C | PRO268 | |
C | ARG269 | |
B | ILE115 | |
B | LYS139 | |
B | GLU142 | |
D | PRO110 | |
D | ILE115 | |
D | LYS139 | |
D | GLU142 | |
C | ARG56 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00001, ECO:0000305|PubMed:3380787 |
Chain | Residue | Details |
A | GLY85 | |
A | THR168 | |
A | VAL230 | |
C | GLY85 | |
C | THR168 | |
C | VAL230 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1at1 |
Chain | Residue | Details |
A | ARG54 | |
A | HIS134 | |
A | ARG105 | |
A | THR55 |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1at1 |
Chain | Residue | Details |
C | ARG54 | |
C | HIS134 | |
C | ARG105 | |
C | THR55 |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 405 |
Chain | Residue | Details |
A | THR55 | electrostatic stabiliser |
A | ARG56 | electrostatic stabiliser, increase electrophilicity |
A | GLY85 | proton shuttle (general acid/base) |
A | HIS106 | electrostatic stabiliser, increase electrophilicity |
A | PRO135 | electrostatic stabiliser, increase electrophilicity |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 405 |
Chain | Residue | Details |
C | THR55 | electrostatic stabiliser |
C | ARG56 | electrostatic stabiliser, increase electrophilicity |
C | GLY85 | proton shuttle (general acid/base) |
C | HIS106 | electrostatic stabiliser, increase electrophilicity |
C | PRO135 | electrostatic stabiliser, increase electrophilicity |