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2IPO

E. coli Aspartate Transcarbamoylase complexed with N-phosphonacetyl-L-asparagine

Functional Information from GO Data
ChainGOidnamespacecontents
A0004070molecular_functionaspartate carbamoyltransferase activity
A0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006221biological_processpyrimidine nucleotide biosynthetic process
A0006520biological_processamino acid metabolic process
A0006541biological_processglutamine metabolic process
A0009347cellular_componentaspartate carbamoyltransferase complex
A0016597molecular_functionamino acid binding
A0016740molecular_functiontransferase activity
A0016743molecular_functioncarboxyl- or carbamoyltransferase activity
A0042802molecular_functionidentical protein binding
A0044205biological_process'de novo' UMP biosynthetic process
A0070207biological_processprotein homotrimerization
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
B0006221biological_processpyrimidine nucleotide biosynthetic process
B0008270molecular_functionzinc ion binding
B0009347cellular_componentaspartate carbamoyltransferase complex
B0046872molecular_functionmetal ion binding
C0004070molecular_functionaspartate carbamoyltransferase activity
C0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
C0006221biological_processpyrimidine nucleotide biosynthetic process
C0006520biological_processamino acid metabolic process
C0006541biological_processglutamine metabolic process
C0009347cellular_componentaspartate carbamoyltransferase complex
C0016597molecular_functionamino acid binding
C0016740molecular_functiontransferase activity
C0016743molecular_functioncarboxyl- or carbamoyltransferase activity
C0042802molecular_functionidentical protein binding
C0044205biological_process'de novo' UMP biosynthetic process
C0070207biological_processprotein homotrimerization
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
D0006221biological_processpyrimidine nucleotide biosynthetic process
D0008270molecular_functionzinc ion binding
D0009347cellular_componentaspartate carbamoyltransferase complex
D0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 201
ChainResidue
BCYS109
BCYS114
BCYS138
BCYS141

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 201
ChainResidue
DCYS109
DCYS114
DCYS138
DCYS141

site_idAC3
Number of Residues19
DetailsBINDING SITE FOR RESIDUE 1IP A 401
ChainResidue
ATHR53
AARG54
ATHR55
ASER80
ALYS84
AARG105
AHIS134
AGLN137
AARG167
ATHR168
AARG229
AGLN231
ALEU267
AHOH408
AHOH409
AHOH436
AHOH448
AHOH507
ASER52

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MAE C 411
ChainResidue
CPRO3
CLEU4
CLYS7
CASP14
CASP19

site_idAC5
Number of Residues18
DetailsBINDING SITE FOR RESIDUE 1IP C 401
ChainResidue
CSER52
CTHR53
CARG54
CTHR55
CSER80
CLYS84
CARG105
CHIS134
CGLN137
CARG167
CTHR168
CARG229
CGLN231
CLEU267
CMAE412
CHOH419
CHOH444
CHOH446

site_idAC6
Number of Residues11
DetailsBINDING SITE FOR RESIDUE MAE C 412
ChainResidue
CARG54
CTHR55
CHIS134
CGLN137
CLEU140
CPRO266
CALA289
CARG296
C1IP401
CHOH441
CHOH483

site_idAC7
Number of Residues9
DetailsBINDING SITE FOR RESIDUE MPD A 402
ChainResidue
APHE48
AGLU50
AALA51
ASER52
AARG56
APHE73
ASER74
AASN78
ATHR79

site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MPD C 413
ChainResidue
CLYS232
CTYR240

Functional Information from PROSITE/UniProt
site_idPS00097
Number of Residues8
DetailsCARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FfEaSTRT
ChainResidueDetails
APHE48-THR55

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING:
ChainResidueDetails
BPRO110
CHIS106
CPRO135
CTHR138
CPRO268
CARG269
BILE115
BLYS139
BGLU142
DPRO110
DILE115
DLYS139
DGLU142
CARG56

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00001, ECO:0000305|PubMed:3380787
ChainResidueDetails
AGLY85
ATHR168
AVAL230
CGLY85
CTHR168
CVAL230

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1at1
ChainResidueDetails
AARG54
AHIS134
AARG105
ATHR55

site_idCSA2
Number of Residues4
DetailsAnnotated By Reference To The Literature 1at1
ChainResidueDetails
CARG54
CHIS134
CARG105
CTHR55

site_idMCSA1
Number of Residues5
DetailsM-CSA 405
ChainResidueDetails
ATHR55electrostatic stabiliser
AARG56electrostatic stabiliser, increase electrophilicity
AGLY85proton shuttle (general acid/base)
AHIS106electrostatic stabiliser, increase electrophilicity
APRO135electrostatic stabiliser, increase electrophilicity

site_idMCSA2
Number of Residues5
DetailsM-CSA 405
ChainResidueDetails
CTHR55electrostatic stabiliser
CARG56electrostatic stabiliser, increase electrophilicity
CGLY85proton shuttle (general acid/base)
CHIS106electrostatic stabiliser, increase electrophilicity
CPRO135electrostatic stabiliser, increase electrophilicity

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PDB entries from 2024-11-20

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