2IP4

Crystal Structure of Glycinamide Ribonucleotide Synthetase from Thermus thermophilus HB8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004637	molecular_function	phosphoribosylamine-glycine ligase activity
A	0005524	molecular_function	ATP binding
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0009113	biological_process	purine nucleobase biosynthetic process
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004637	molecular_function	phosphoribosylamine-glycine ligase activity
B	0005524	molecular_function	ATP binding
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006189	biological_process	'de novo' IMP biosynthetic process
B	0009113	biological_process	purine nucleobase biosynthetic process
B	0016874	molecular_function	ligase activity
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 418

Chain	Residue
A	ARG11
A	GLU70
A	ARG281

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 419

Chain	Residue
A	TYR332
A	GLY370
A	ARG371

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 418

Chain	Residue
B	TYR332
B	ARG371
B	HOH427

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 419

Chain	Residue
B	ARG11
B	PRO69
B	GLU70
B	ARG281
B	HOH432

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Functional Information from PROSITE/UniProt

site_id	PS00184
Number of Residues	8
Details	GARS Phosphoribosylglycinamide synthetase signature. RFGDPEaQ

Chain	Residue	Details
A	ARG281-GLN288

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