2IOC
The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partenring
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 401 |
| Chain | Residue |
| B | ASP18 |
| B | GLU20 |
| B | ASP200 |
| B | D5M303 |
| B | MN402 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MN B 402 |
| Chain | Residue |
| B | HOH474 |
| B | HOH508 |
| B | HOH516 |
| B | ASP18 |
| B | D5M303 |
| B | MN401 |
| B | HOH473 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 403 |
| Chain | Residue |
| A | ASP18 |
| A | GLU20 |
| A | ASP200 |
| A | D5M302 |
| A | MN404 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 404 |
| Chain | Residue |
| A | ASP18 |
| A | D5M302 |
| A | MN403 |
| A | HOH466 |
| A | HOH468 |
| A | HOH510 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE D5M A 302 |
| Chain | Residue |
| A | ASP18 |
| A | LEU19 |
| A | GLU20 |
| A | ALA21 |
| A | GLY23 |
| A | LEU24 |
| A | SER78 |
| A | ALA81 |
| A | ILE84 |
| A | THR85 |
| A | TYR129 |
| A | HIS195 |
| A | ASP200 |
| A | MN403 |
| A | MN404 |
| A | HOH410 |
| A | HOH448 |
| A | HOH466 |
| site_id | AC6 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE D5M B 303 |
| Chain | Residue |
| B | ASP18 |
| B | LEU19 |
| B | GLU20 |
| B | ALA21 |
| B | GLY23 |
| B | LEU24 |
| B | SER78 |
| B | GLY80 |
| B | ALA81 |
| B | ILE84 |
| B | THR85 |
| B | TYR129 |
| B | HIS195 |
| B | ASP200 |
| B | MN401 |
| B | MN402 |
| B | HOH404 |
| B | HOH437 |
| B | HOH441 |
| B | HOH474 |
| B | HOH500 |
| B | HOH508 |
| B | HOH516 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"17355961","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17293595","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17355961","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18780819","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22071149","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9NSU2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
