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2IOC

The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partenring

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0008408molecular_function3'-5' exonuclease activity
B0003676molecular_functionnucleic acid binding
B0008408molecular_function3'-5' exonuclease activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN B 401
ChainResidue
BASP18
BGLU20
BASP200
BD5M303
BMN402

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MN B 402
ChainResidue
BHOH474
BHOH508
BHOH516
BASP18
BD5M303
BMN401
BHOH473

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN A 403
ChainResidue
AASP18
AGLU20
AASP200
AD5M302
AMN404

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN A 404
ChainResidue
AASP18
AD5M302
AMN403
AHOH466
AHOH468
AHOH510

site_idAC5
Number of Residues18
DetailsBINDING SITE FOR RESIDUE D5M A 302
ChainResidue
AASP18
ALEU19
AGLU20
AALA21
AGLY23
ALEU24
ASER78
AALA81
AILE84
ATHR85
ATYR129
AHIS195
AASP200
AMN403
AMN404
AHOH410
AHOH448
AHOH466

site_idAC6
Number of Residues23
DetailsBINDING SITE FOR RESIDUE D5M B 303
ChainResidue
BASP18
BLEU19
BGLU20
BALA21
BGLY23
BLEU24
BSER78
BGLY80
BALA81
BILE84
BTHR85
BTYR129
BHIS195
BASP200
BMN401
BMN402
BHOH404
BHOH437
BHOH441
BHOH474
BHOH500
BHOH508
BHOH516

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:17355961
ChainResidueDetails
BHIS195
AHIS195

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:17293595, ECO:0000269|PubMed:17355961, ECO:0000269|PubMed:18780819, ECO:0000269|PubMed:22071149
ChainResidueDetails
BASP18
BGLU20
BTYR129
BASP200
AASP18
AGLU20
ATYR129
AASP200

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9NSU2
ChainResidueDetails
BSER78
BSER167
ASER78
ASER167

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PDB entries from 2024-10-30

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