2IM3

Crystal structure of poliovirus polymerase complexed with UTP and Mn2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0006351	biological_process	DNA-templated transcription
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN A 2001

Chain	Residue
A	TYR234
A	ASP328
A	UTP1001

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MN A 2002

Chain	Residue
A	ASP328

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 3001

Chain	Residue
A	GLY285
A	LEU268
A	ASN269
A	SER271
A	VAL282
A	GLY284

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site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE UTP A 1001

Chain	Residue
A	ARG163
A	LYS167
A	ARG174
A	LEU175
A	ILE176
A	TYR234
A	THR235
A	GLY236
A	TYR237
A	ASP238
A	SER288
A	LYS359
A	HOH536
A	HOH582
A	HOH583
A	MN2001

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site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY A 901

Chain	Residue
A	ILE401
A	TRP403
A	THR404
A	THR410
A	HIS413

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACY A 902

Chain	Residue
A	ASP71
A	ASP349
A	TYR350

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site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACY A 903

Chain	Residue
A	TYR334
A	PRO440
A	ARG443
A	HOH557

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site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ACY A 904

Chain	Residue
A	ARG379

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21148772","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21148772","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2196557","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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