2IM2

Crystal structure of poliovirus polymerase complexed with UTP and Mg2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0006351	biological_process	DNA-templated transcription
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 3001

Chain	Residue
A	LEU268
A	ASN269
A	SER271
A	GLY284
A	GLY285
A	HOH669

---

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE UTP A 1001

Chain	Residue
A	LEU175
A	ILE176
A	TYR234
A	THR235
A	GLY236
A	TYR237
A	ASP238
A	SER288
A	HOH548
A	HOH606
A	HOH656
A	HOH672
A	HOH677
A	HOH678
A	HOH696
A	HOH726
A	ARG163
A	LYS167
A	ARG174

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACY A 901

Chain	Residue
A	ILE401
A	TRP403
A	THR404
A	THR410
A	HIS413
A	HOH633

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACY A 902

Chain	Residue
A	ASP71
A	TYR350

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACY A 903

Chain	Residue
A	LYS375
A	HOH686

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY A 904

Chain	Residue
A	TYR334
A	HIS336
A	PRO440
A	ARG443
A	HOH579

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21148772","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21148772","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2196557","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---