2IHW

Crystal structure of a cubic core of the dihydrolipoamide acyltransferase (E2b) component in the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), apo form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016746	molecular_function	acyltransferase activity
B	0016746	molecular_function	acyltransferase activity
C	0016746	molecular_function	acyltransferase activity
D	0016746	molecular_function	acyltransferase activity
E	0016746	molecular_function	acyltransferase activity
F	0016746	molecular_function	acyltransferase activity
G	0016746	molecular_function	acyltransferase activity
H	0016746	molecular_function	acyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 600

Chain	Residue
A	PRO350
A	VAL351
A	LEU353
A	ILE359
A	ACT601

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 601

Chain	Residue
B	GLY396
A	ASP288
A	LEU293
A	ACT600
B	HIS391

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 600

Chain	Residue
B	PRO350
B	VAL351
B	LEU353
B	ILE359
B	ACT601

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT B 601

Chain	Residue
B	ASP288
B	LEU293
B	ACT600
C	HIS391
C	ASP395
C	GLY396

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT C 600

Chain	Residue
A	PHE215
C	VAL351
C	LEU353
C	ACT601

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT C 601

Chain	Residue
A	HIS391
A	ASP395
A	GLY396
C	ASP288
C	LEU293
C	ACT600

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT D 600

Chain	Residue
D	PRO350
D	VAL351
D	ILE359
D	ACT601

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT D 601

Chain	Residue
D	ASP288
D	LEU293
D	ACT600
E	HIS391
E	ASP395
E	GLY396

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT E 600

Chain	Residue
E	PRO350
E	VAL351
E	LEU353
E	ACT601
F	PHE215

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT E 601

Chain	Residue
E	ASP288
E	LEU293
E	SER338
E	ACT600
F	HIS391
F	ASP395
F	GLY396

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT F 600

Chain	Residue
F	PRO350
F	VAL351
F	LEU353
F	ILE359
F	ACT601

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT F 601

Chain	Residue
D	HIS391
D	ASP395
D	GLY396
F	ASP288
F	LEU293
F	ACT600

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT G 600

Chain	Residue
G	MET206
G	PRO350
G	VAL351
G	LEU353
G	ILE359
G	ACT601

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT G 601

Chain	Residue
G	ASP288
G	LEU293
G	HIS391
G	GLY396
G	ACT600

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT H 600

Chain	Residue
H	PHE215
H	PRO350
H	VAL351
H	LEU353
H	ILE359
H	ACT601

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT H 601

Chain	Residue
H	ASP288
H	LEU293
H	HIS391
H	ASP395
H	GLY396
H	ACT600

---

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL H 602

Chain	Residue
H	HOH77
H	LYS349

---

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 602

Chain	Residue
A	HOH10
C	LYS349

---

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 602

Chain	Residue
A	LYS349
B	HOH100

---

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 602

Chain	Residue
E	LYS349
F	HOH31

---

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL F 602

Chain	Residue
D	HOH59
F	LYS349

---

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 602

Chain	Residue
B	LYS349
C	HOH93

---

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 602

Chain	Residue
G	ARG370
G	ARG370
G	ARG370

---

site_id	CC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 603

Chain	Residue
C	ARG370

---

site_id	CC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 603

Chain	Residue
F	ARG370

---

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 602

Chain	Residue
D	LYS349
E	HOH63

---

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL G 603

Chain	Residue
G	HOH122
G	LYS349

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17124494","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2II4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P53395","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P53395","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P53395","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P11182","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---