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2IH3

Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation

Functional Information from GO Data
ChainGOidnamespacecontents
C0005249molecular_functionvoltage-gated potassium channel activity
C0006813biological_processpotassium ion transport
C0008076cellular_componentvoltage-gated potassium channel complex
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE K C 201
ChainResidue
CTHR75
CK202
CK202
CK202
CK204
CK204
CK204
CK204
CTHR75
CTHR75
CTHR75
CVAL76
CVAL76
CVAL76
CVAL76
CK202

site_idAC2
Number of Residues16
DetailsBINDING SITE FOR RESIDUE K C 202
ChainResidue
CVAL76
CVAL76
CVAL76
CVAL76
CDAL77
CDAL77
CDAL77
CDAL77
CK201
CK201
CK201
CK201
CK203
CK203
CK203
CK203

site_idAC3
Number of Residues12
DetailsBINDING SITE FOR RESIDUE K C 203
ChainResidue
CDAL77
CDAL77
CDAL77
CDAL77
CTYR78
CTYR78
CTYR78
CTYR78
CK202
CK202
CK202
CK202

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE K C 204
ChainResidue
CTHR75
CTHR75
CTHR75
CTHR75
CK201
CK201
CK201
CK201

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE K C 206
ChainResidue
CK207
CK207
CK207
CK207

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE K C 207
ChainResidue
CK206
CK206
CK206
CK206

site_idAC7
Number of Residues8
DetailsBINDING SITE FOR RESIDUE 1EM C 301
ChainResidue
ATHR30
ASER31
CPRO63
CCYS70
CVAL84
CLEU86
CARG89
CLEU90

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
BTYR192-HIS198

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues45
DetailsTRANSMEM: Helical
ChainResidueDetails
CALA28-ALA50
CGLY88-ALA111

site_idSWS_FT_FI2
Number of Residues16
DetailsTOPO_DOM: Extracellular
ChainResidueDetails
CGLU51-THR61
CLEU81-TRP87

site_idSWS_FT_FI3
Number of Residues10
DetailsINTRAMEM: Helical; Pore-forming
ChainResidueDetails
CTYR62-THR72

site_idSWS_FT_FI4
Number of Residues7
DetailsINTRAMEM: Pore-forming
ChainResidueDetails
CALA73-ASP80

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PDB entries from 2024-11-06

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