2IDV

Crystal structure of wheat C113S mutant EIF4E bound TO 7-methyl-GDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003743	molecular_function	translation initiation factor activity
A	0005737	cellular_component	cytoplasm
A	0006413	biological_process	translational initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE M7G A 1000

Chain	Residue
A	ARG58
A	HOH1076
A	HOH1092
A	HOH1093
A	TRP62
A	LYS107
A	TRP108
A	GLU109
A	ARG158
A	ARG163
A	HOH1012
A	HOH1066

---

Functional Information from PROSITE/UniProt

site_id	PS00813
Number of Residues	24
Details	IF4E Eukaryotic initiation factor 4E signature. DFhcFKnkIePkWEDpisanGGKW

Chain	Residue	Details
A	ASP96-TRP119

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Region: {"description":"EIF4G-binding","evidences":[{"source":"UniProtKB","id":"Q00LS8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17322339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2IDV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q00LS8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---