2ICF

CRIg bound to C3b

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004866	molecular_function	endopeptidase inhibitor activity
B	0004866	molecular_function	endopeptidase inhibitor activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
S	0032703	biological_process	negative regulation of interleukin-2 production
S	0042130	biological_process	negative regulation of T cell proliferation
S	0043031	biological_process	negative regulation of macrophage activation

Functional Information from PROSITE/UniProt

site_id	PS00477
Number of Residues	9
Details	ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEQnM

Chain	Residue	Details
B	PRO985-MET993

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by factor I => ECO:0000255

Chain	Residue	Details
B	ARG932

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Cleavage; by factor I

Chain	Residue	Details
B	ARG1281
B	ARG1298
A	SER275
A	SER281

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Coordinates Mg2+ for interaction with Complement factor B Bb fragment => ECO:0000269|PubMed:28264884, ECO:0000269|PubMed:31507604

Chain	Residue	Details
B	ASN1641

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site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039

Chain	Residue	Details
B	SER946
B	SER1299
B	SER1551

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17051150

Chain	Residue	Details
B	ASN917

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952

Chain	Residue	Details
B	ASN1595

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CROSSLNK: Isoglutamyl cysteine thioester (Cys-Gln)

Chain	Residue	Details
B	CYS988
B	GLN991

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1hzf

Chain	Residue	Details
B	GLN991
B	CYS988

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