2IBZ

Yeast Cytochrome BC1 Complex with Stigmatellin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005750	cellular_component	mitochondrial respiratory chain complex III
A	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
A	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
A	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
A	0009060	biological_process	aerobic respiration
A	0016020	cellular_component	membrane
A	0045333	biological_process	cellular respiration
A	0046872	molecular_function	metal ion binding
A	0070469	cellular_component	respirasome
A	1902600	biological_process	proton transmembrane transport
B	0004222	molecular_function	metalloendopeptidase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005750	cellular_component	mitochondrial respiratory chain complex III
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0006508	biological_process	proteolysis
B	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
B	0009060	biological_process	aerobic respiration
B	0016020	cellular_component	membrane
B	0030061	cellular_component	mitochondrial crista
B	0045333	biological_process	cellular respiration
B	0046872	molecular_function	metal ion binding
B	0070469	cellular_component	respirasome
B	1902600	biological_process	proton transmembrane transport
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005750	cellular_component	mitochondrial respiratory chain complex III
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0009060	biological_process	aerobic respiration
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0022904	biological_process	respiratory electron transport chain
C	0045275	cellular_component	respiratory chain complex III
C	0045333	biological_process	cellular respiration
C	0046872	molecular_function	metal ion binding
C	0070469	cellular_component	respirasome
C	1902600	biological_process	proton transmembrane transport
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
E	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
E	0016020	cellular_component	membrane
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005750	cellular_component	mitochondrial respiratory chain complex III
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
F	0009060	biological_process	aerobic respiration
F	0016020	cellular_component	membrane
F	0034551	biological_process	mitochondrial respiratory chain complex III assembly
F	0045333	biological_process	cellular respiration
F	0070469	cellular_component	respirasome
F	0099617	cellular_component	matrix side of mitochondrial inner membrane
F	1902600	biological_process	proton transmembrane transport
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005750	cellular_component	mitochondrial respiratory chain complex III
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0009060	biological_process	aerobic respiration
G	0016020	cellular_component	membrane
G	0045333	biological_process	cellular respiration
G	0070469	cellular_component	respirasome
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0005750	cellular_component	mitochondrial respiratory chain complex III
I	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
I	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
I	0009060	biological_process	aerobic respiration
I	0016020	cellular_component	membrane
I	0034551	biological_process	mitochondrial respiratory chain complex III assembly
I	0045333	biological_process	cellular respiration
I	0070469	cellular_component	respirasome
I	1902600	biological_process	proton transmembrane transport
X	0002250	biological_process	adaptive immune response
X	0002376	biological_process	immune system process
X	0003823	molecular_function	antigen binding
X	0005576	cellular_component	extracellular region
X	0005886	cellular_component	plasma membrane
X	0016064	biological_process	immunoglobulin mediated immune response
X	0019814	cellular_component	immunoglobulin complex
X	0072562	cellular_component	blood microparticle
Y	0005615	cellular_component	extracellular space
Y	0006955	biological_process	immune response

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEC C 401

Chain	Residue
C	LEU40
C	THR127
C	ALA128
C	GLY131
C	VAL135
C	HIS183
C	TYR184
C	PRO187
C	HOH526
C	HOH538
C	GLN43
C	GLY47
C	ILE48
C	MET50
C	ALA51
C	ARG79
C	HIS82
C	PHE89

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEC C 402

Chain	Residue
C	TRP30
C	GLY33
C	LEU36
C	HIS96
C	LYS99
C	SER105
C	LEU113
C	TRP114
C	GLY117
C	VAL118
C	ILE120
C	HIS197
C	LEU201
C	SER206
C	SER207
C	UQ6506
C	HOH508
C	HOH527

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEC D 3

Chain	Residue
D	VAL100
D	CYS101
D	CYS104
D	HIS105
D	ASN169
D	PRO175
D	ARG184
D	TYR190
D	ILE191
D	PHE218
D	ILE223
D	ALA224
D	MET225
D	VAL228
D	HOH319

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FES E 4

Chain	Residue
E	CYS159
E	HIS161
E	LEU162
E	CYS178
E	HIS181
E	SER183

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE UQ6 C 506

Chain	Residue
C	TYR16
C	GLN22
C	ILE44
C	LEU185
C	LEU201
C	SER206
C	MET221
C	ASP229
C	HEC402

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SMA C 505

Chain	Residue
C	ILE125
C	VAL146
C	PRO271
C	GLU272
C	LEU275
C	TYR279
C	MET295
C	PHE296
C	HOH545
E	HIS181

---

Functional Information from PROSITE/UniProt

site_id	PS00143
Number of Residues	23
Details	INSULINASE Insulinase family, zinc-binding region signature. Ggsryatkd.GvAHLLNRFnFqNT

Chain	Residue	Details
B	GLY37-THR59

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554

Chain	Residue	Details
E	LYS31-ASP50
C	GLY205-SER223
C	ASP309-LYS319
C	ILE365-LYS385
C	TYR103-ARG110

---

site_id	SWS_FT_FI2
Number of Residues	29
Details	TRANSMEM: Helical => ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554

Chain	Residue	Details
E	LYS51-SER80
C	ASN173-HIS204
C	TYR224-TYR246
C	LYS288-THR308
C	VAL320-GLY340
C	TYR348-LEU364
C	GLY75-TYR102
C	VAL111-VAL135

---

site_id	SWS_FT_FI3
Number of Residues	134
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554

Chain	Residue	Details
E	SER81-GLY215
C	SER247-ASP287
C	ALA341-PRO347
C	TYR136-SER172

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:10873857, ECO:0000269|PubMed:11880631, ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554, ECO:0007744|PDB:1EZV, ECO:0007744|PDB:1KB9, ECO:0007744|PDB:1KYO, ECO:0007744|PDB:1P84, ECO:0007744|PDB:2IBZ, ECO:0007744|PDB:3CX5, ECO:0007744|PDB:3CXH, ECO:0007744|PDB:4PD4

Chain	Residue	Details
E	CYS159
E	CYS178
E	HIS181
E	HIS161

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0000269|PubMed:11880631, ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554, ECO:0007744|PDB:1KYO

Chain	Residue	Details
C	HIS183
C	HIS197
D	HIS105
C	HIS96

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0000269|PubMed:10873857, ECO:0000269|PubMed:11880631, ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554, ECO:0007744|PDB:1EZV, ECO:0007744|PDB:1KYO

Chain	Residue	Details
D	MET225

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 208

Chain	Residue	Details
E	HIS181	covalently attached, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
C	SER206	electrostatic stabiliser, hydrogen bond donor, radical stabiliser
C	LYS228	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
C	ASP229	electrostatic stabiliser, hydrogen bond acceptor, radical stabiliser
C	GLU272	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser

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