Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0008442 | molecular_function | 3-hydroxyisobutyrate dehydrogenase activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0050661 | molecular_function | NADP binding |
A | 0051287 | molecular_function | NAD binding |
B | 0008442 | molecular_function | 3-hydroxyisobutyrate dehydrogenase activity |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0050661 | molecular_function | NADP binding |
B | 0051287 | molecular_function | NAD binding |
C | 0008442 | molecular_function | 3-hydroxyisobutyrate dehydrogenase activity |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0050661 | molecular_function | NADP binding |
C | 0051287 | molecular_function | NAD binding |
D | 0008442 | molecular_function | 3-hydroxyisobutyrate dehydrogenase activity |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0050661 | molecular_function | NADP binding |
D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE NAD A 500 |
Chain | Residue |
A | ILE45 |
A | MET102 |
A | LEU103 |
A | PRO104 |
A | ASN108 |
A | THR134 |
A | VAL159 |
A | GLY161 |
A | GLY162 |
A | LYS209 |
A | PHE277 |
A | GLY46 |
A | LEU281 |
A | LYS284 |
A | ASP285 |
A | GLY48 |
A | ASN49 |
A | MET50 |
A | TYR68 |
A | ASP69 |
A | VAL70 |
A | PHE71 |
site_id | AC2 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE NAD B 500 |
Chain | Residue |
B | ILE45 |
B | GLY46 |
B | GLY48 |
B | ASN49 |
B | MET50 |
B | TYR68 |
B | ASP69 |
B | VAL70 |
B | MET102 |
B | LEU103 |
B | PRO104 |
B | ASN108 |
B | THR134 |
B | VAL159 |
B | GLY161 |
B | GLY162 |
B | LYS209 |
B | PHE277 |
B | LEU281 |
B | LYS284 |
B | ASP285 |
site_id | AC3 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE NAD C 500 |
Chain | Residue |
C | ILE45 |
C | GLY46 |
C | GLY48 |
C | ASN49 |
C | MET50 |
C | GLY51 |
C | TYR68 |
C | ASP69 |
C | VAL70 |
C | PHE71 |
C | MET102 |
C | LEU103 |
C | PRO104 |
C | ASN108 |
C | THR134 |
C | VAL159 |
C | GLY161 |
C | GLY162 |
C | LYS209 |
C | LYS284 |
C | ASP285 |
site_id | AC4 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE NAD D 500 |
Chain | Residue |
D | GLY46 |
D | GLY48 |
D | ASN49 |
D | MET50 |
D | TYR68 |
D | ASP69 |
D | VAL70 |
D | PHE71 |
D | MET102 |
D | LEU103 |
D | PRO104 |
D | ASN108 |
D | THR134 |
D | VAL159 |
D | GLY161 |
D | GLY162 |
D | LYS209 |
D | PHE277 |
D | LYS284 |
D | ASP285 |
Functional Information from PROSITE/UniProt
site_id | PS00895 |
Number of Residues | 14 |
Details | 3_HYDROXYISOBUT_DH 3-hydroxyisobutyrate dehydrogenase signature. FIGLGnMGnpMAkN |
Chain | Residue | Details |
A | PHE44-ASN57 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: ACT_SITE => ECO:0000250 |
Chain | Residue | Details |
A | LYS209 | |
B | LYS209 | |
C | LYS209 | |
D | LYS209 | |
site_id | SWS_FT_FI2 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000269|Ref.12 |
Chain | Residue | Details |
A | MET40 | |
B | LYS284 | |
C | MET40 | |
C | LEU103 | |
C | ASN108 | |
C | THR134 | |
C | LYS284 | |
D | MET40 | |
D | LEU103 | |
D | ASN108 | |
D | THR134 | |
A | LEU103 | |
D | LYS284 | |
A | ASN108 | |
A | THR134 | |
A | LYS284 | |
B | MET40 | |
B | LEU103 | |
B | ASN108 | |
B | THR134 | |
Chain | Residue | Details |
A | LYS60 | |
B | LYS238 | |
B | LYS242 | |
B | LYS321 | |
C | LYS60 | |
C | LYS76 | |
C | LYS149 | |
C | LYS238 | |
C | LYS242 | |
C | LYS321 | |
D | LYS60 | |
A | LYS76 | |
D | LYS76 | |
D | LYS149 | |
D | LYS238 | |
D | LYS242 | |
D | LYS321 | |
A | LYS149 | |
A | LYS238 | |
A | LYS242 | |
A | LYS321 | |
B | LYS60 | |
B | LYS76 | |
B | LYS149 | |
Chain | Residue | Details |
A | LYS95 | |
D | LYS95 | |
D | LYS141 | |
D | LYS297 | |
A | LYS141 | |
A | LYS297 | |
B | LYS95 | |
B | LYS141 | |
B | LYS297 | |
C | LYS95 | |
C | LYS141 | |
C | LYS297 | |
Chain | Residue | Details |
A | LYS121 | |
A | LYS145 | |
B | LYS121 | |
B | LYS145 | |
C | LYS121 | |
C | LYS145 | |
D | LYS121 | |
D | LYS145 | |