2I9P
Crystal structure of human hydroxyisobutyrate dehydrogenase complexed with NAD+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008442 | molecular_function | 3-hydroxyisobutyrate dehydrogenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0008442 | molecular_function | 3-hydroxyisobutyrate dehydrogenase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| C | 0008442 | molecular_function | 3-hydroxyisobutyrate dehydrogenase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0050661 | molecular_function | NADP binding |
| C | 0051287 | molecular_function | NAD binding |
| D | 0008442 | molecular_function | 3-hydroxyisobutyrate dehydrogenase activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0050661 | molecular_function | NADP binding |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE NAD A 500 |
| Chain | Residue |
| A | ILE45 |
| A | MET102 |
| A | LEU103 |
| A | PRO104 |
| A | ASN108 |
| A | THR134 |
| A | VAL159 |
| A | GLY161 |
| A | GLY162 |
| A | LYS209 |
| A | PHE277 |
| A | GLY46 |
| A | LEU281 |
| A | LYS284 |
| A | ASP285 |
| A | GLY48 |
| A | ASN49 |
| A | MET50 |
| A | TYR68 |
| A | ASP69 |
| A | VAL70 |
| A | PHE71 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NAD B 500 |
| Chain | Residue |
| B | ILE45 |
| B | GLY46 |
| B | GLY48 |
| B | ASN49 |
| B | MET50 |
| B | TYR68 |
| B | ASP69 |
| B | VAL70 |
| B | MET102 |
| B | LEU103 |
| B | PRO104 |
| B | ASN108 |
| B | THR134 |
| B | VAL159 |
| B | GLY161 |
| B | GLY162 |
| B | LYS209 |
| B | PHE277 |
| B | LEU281 |
| B | LYS284 |
| B | ASP285 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NAD C 500 |
| Chain | Residue |
| C | ILE45 |
| C | GLY46 |
| C | GLY48 |
| C | ASN49 |
| C | MET50 |
| C | GLY51 |
| C | TYR68 |
| C | ASP69 |
| C | VAL70 |
| C | PHE71 |
| C | MET102 |
| C | LEU103 |
| C | PRO104 |
| C | ASN108 |
| C | THR134 |
| C | VAL159 |
| C | GLY161 |
| C | GLY162 |
| C | LYS209 |
| C | LYS284 |
| C | ASP285 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE NAD D 500 |
| Chain | Residue |
| D | GLY46 |
| D | GLY48 |
| D | ASN49 |
| D | MET50 |
| D | TYR68 |
| D | ASP69 |
| D | VAL70 |
| D | PHE71 |
| D | MET102 |
| D | LEU103 |
| D | PRO104 |
| D | ASN108 |
| D | THR134 |
| D | VAL159 |
| D | GLY161 |
| D | GLY162 |
| D | LYS209 |
| D | PHE277 |
| D | LYS284 |
| D | ASP285 |
Functional Information from PROSITE/UniProt
| site_id | PS00895 |
| Number of Residues | 14 |
| Details | 3_HYDROXYISOBUT_DH 3-hydroxyisobutyrate dehydrogenase signature. FIGLGnMGnpMAkN |
| Chain | Residue | Details |
| A | PHE44-ASN57 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2006","submissionDatabase":"PDB data bank","title":"Crystal structure of human hydroxyisobutyrate dehydrogenase.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q99L13","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q99L13","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q99L13","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
