2I9A

Crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (ATF)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008236	molecular_function	serine-type peptidase activity
A	0031639	biological_process	plasminogen activation
B	0008236	molecular_function	serine-type peptidase activity
B	0031639	biological_process	plasminogen activation
C	0008236	molecular_function	serine-type peptidase activity
C	0031639	biological_process	plasminogen activation
D	0008236	molecular_function	serine-type peptidase activity
D	0031639	biological_process	plasminogen activation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 C 802

Chain	Residue
B	ARG109
C	ASN75
C	HIS87
C	LYS98

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 D 803

Chain	Residue
D	HOH872
D	HOH883
D	HOH895
A	ARG109
A	HOH190
D	ASN75
D	HIS87
D	LYS98

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 D 804

Chain	Residue
D	ARG110
D	HIS129
D	HOH901

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 D 805

Chain	Residue
D	ARG108
D	ARG109

---

Functional Information from PROSITE/UniProt

site_id	PS00021
Number of Residues	13
Details	KRINGLE_1 Kringle domain signature. YCRNpdnrrrp.WC

Chain	Residue	Details
A	TYR101-CYS113

---

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CnCpkKfgGQhC

Chain	Residue	Details
A	CYS31-CYS42

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	324
Details	Domain: {"description":"Kringle","evidences":[{"source":"PROSITE-ProRule","id":"PRU00121","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	92
Details	Region: {"description":"Binds urokinase plasminogen activator surface receptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Glycosylation: {"description":"O-linked (Fuc) threonine","evidences":[{"source":"PubMed","id":"2023947","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	36
Details	Domain: {"description":"EGF-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---