2I62
Mouse Nicotinamide N-methyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006769 | biological_process | nicotinamide metabolic process |
| A | 0008112 | molecular_function | nicotinamide N-methyltransferase activity |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019677 | biological_process | NAD+ catabolic process |
| A | 0032259 | biological_process | methylation |
| A | 0045722 | biological_process | positive regulation of gluconeogenesis |
| A | 0090312 | biological_process | positive regulation of protein deacetylation |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006769 | biological_process | nicotinamide metabolic process |
| B | 0008112 | molecular_function | nicotinamide N-methyltransferase activity |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019677 | biological_process | NAD+ catabolic process |
| B | 0032259 | biological_process | methylation |
| B | 0045722 | biological_process | positive regulation of gluconeogenesis |
| B | 0090312 | biological_process | positive regulation of protein deacetylation |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006769 | biological_process | nicotinamide metabolic process |
| C | 0008112 | molecular_function | nicotinamide N-methyltransferase activity |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0019677 | biological_process | NAD+ catabolic process |
| C | 0032259 | biological_process | methylation |
| C | 0045722 | biological_process | positive regulation of gluconeogenesis |
| C | 0090312 | biological_process | positive regulation of protein deacetylation |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006769 | biological_process | nicotinamide metabolic process |
| D | 0008112 | molecular_function | nicotinamide N-methyltransferase activity |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0019677 | biological_process | NAD+ catabolic process |
| D | 0032259 | biological_process | methylation |
| D | 0045722 | biological_process | positive regulation of gluconeogenesis |
| D | 0090312 | biological_process | positive regulation of protein deacetylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE SAH A 4001 |
| Chain | Residue |
| A | TYR12 |
| A | TYR87 |
| A | THR88 |
| A | ASN91 |
| A | CYS142 |
| A | ASP143 |
| A | VAL144 |
| A | THR164 |
| A | LEU165 |
| A | ALA170 |
| A | HOH4014 |
| A | TYR21 |
| A | HOH4070 |
| A | HOH4075 |
| A | TYR26 |
| A | GLY64 |
| A | SER65 |
| A | GLY66 |
| A | THR68 |
| A | TYR70 |
| A | ASP86 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SAH B 4002 |
| Chain | Residue |
| B | TYR12 |
| B | TYR21 |
| B | TYR26 |
| B | GLY64 |
| B | SER65 |
| B | GLY66 |
| B | THR68 |
| B | TYR70 |
| B | ASP86 |
| B | TYR87 |
| B | THR88 |
| B | ASN91 |
| B | ASP143 |
| B | VAL144 |
| B | THR164 |
| B | LEU165 |
| B | ALA170 |
| B | HOH4038 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SAH C 4003 |
| Chain | Residue |
| C | TYR12 |
| C | TYR21 |
| C | TYR26 |
| C | GLY64 |
| C | SER65 |
| C | GLY66 |
| C | THR68 |
| C | TYR70 |
| C | ASP86 |
| C | TYR87 |
| C | THR88 |
| C | ASN91 |
| C | CYS142 |
| C | ASP143 |
| C | VAL144 |
| C | THR145 |
| C | THR164 |
| C | LEU165 |
| C | HOH4022 |
| C | HOH4043 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SAH D 4004 |
| Chain | Residue |
| D | TYR12 |
| D | TYR21 |
| D | TYR26 |
| D | GLY64 |
| D | SER65 |
| D | GLY66 |
| D | THR68 |
| D | TYR70 |
| D | ASP86 |
| D | TYR87 |
| D | THR88 |
| D | ASN91 |
| D | CYS142 |
| D | ASP143 |
| D | VAL144 |
| D | THR164 |
| D | LEU165 |
| D | HOH4026 |
| D | HOH4036 |
Functional Information from PROSITE/UniProt
| site_id | PS01100 |
| Number of Residues | 17 |
| Details | NNMT_PNMT_TEMT NNMT/PNMT/TEMT family of methyltransferases signature. LIDIGSGPTIYQLLSAC |
| Chain | Residue | Details |
| A | LEU60-CYS76 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29483571","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"AUG-2006","submissionDatabase":"PDB data bank","title":"The Crystal Structure of Mouse Nicotinamide N-methyltransferase in complex with SAH.","authors":["Wu H.","Min J.","Zeng H.","Loppnau P.","Weigelt J.","Sundstrom M.","Arrowsmith C.H.","Edwards A.M.","Bochkarev A.","Plotnikov A.N."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P40261","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"Citrulline; alternate","evidences":[{"source":"UniProtKB","id":"P40261","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
