2I54

Phosphomannomutase from Leishmania mexicana

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004615	molecular_function	phosphomannomutase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006013	biological_process	mannose metabolic process
A	0006487	biological_process	protein N-linked glycosylation
A	0009247	biological_process	glycolipid biosynthetic process
A	0009298	biological_process	GDP-mannose biosynthetic process
A	0016020	cellular_component	membrane
A	0016853	molecular_function	isomerase activity
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding
A	0061728	biological_process	GDP-mannose biosynthetic process from mannose
A	0061729	biological_process	GDP-D-mannose biosynthetic process from fructose-6-phosphate
B	0000287	molecular_function	magnesium ion binding
B	0004615	molecular_function	phosphomannomutase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006013	biological_process	mannose metabolic process
B	0006487	biological_process	protein N-linked glycosylation
B	0009247	biological_process	glycolipid biosynthetic process
B	0009298	biological_process	GDP-mannose biosynthetic process
B	0016020	cellular_component	membrane
B	0016853	molecular_function	isomerase activity
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0046872	molecular_function	metal ion binding
B	0061728	biological_process	GDP-mannose biosynthetic process from mannose
B	0061729	biological_process	GDP-D-mannose biosynthetic process from fructose-6-phosphate
C	0000287	molecular_function	magnesium ion binding
C	0004615	molecular_function	phosphomannomutase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006013	biological_process	mannose metabolic process
C	0006487	biological_process	protein N-linked glycosylation
C	0009247	biological_process	glycolipid biosynthetic process
C	0009298	biological_process	GDP-mannose biosynthetic process
C	0016020	cellular_component	membrane
C	0016853	molecular_function	isomerase activity
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0046872	molecular_function	metal ion binding
C	0061728	biological_process	GDP-mannose biosynthetic process from mannose
C	0061729	biological_process	GDP-D-mannose biosynthetic process from fructose-6-phosphate

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1001

Chain	Residue
A	PHE118
A	PHE118
A	VAL119
A	VAL119

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 1002

Chain	Residue
B	PHE118
B	VAL119
C	PHE118
C	VAL119

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 2001

Chain	Residue
B	ASP12
B	ASP207
B	ASP10

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 2002

Chain	Residue
A	ASP10
A	ASP12
A	ASP207

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 2003

Chain	Residue
C	ASP10
C	ASP12
C	ASP207
C	HOH3030

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CIT A 3001

Chain	Residue
A	ARG133
A	ARG140
A	GLY175
A	GLN176
A	ILE177
A	SER178
A	HOH3036

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE CIT B 3002

Chain	Residue
B	SER46
B	LYS50
B	ARG122
B	ASN127
B	ARG133
B	ARG140
B	GLY174
B	GLY175
B	GLN176
B	ILE177
B	SER178
B	ASP180
B	HOH3025
B	HOH3038

---

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CIT C 3003

Chain	Residue
C	SER46
C	LYS50
C	ARG122
C	ASN127
C	ARG133
C	ARG140
C	GLY174
C	GLY175
C	GLN176
C	ILE177
C	SER178
C	ASP180
C	HOH3022
C	HOH3084
C	HOH3085

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PIRSR","id":"PIRSR605002-1","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11689705","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16963079","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PIRSR","id":"PIRSR605002-1","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16963079","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PIRSR","id":"PIRSR605002-3","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16963079","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2I54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I55","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PIRSR","id":"PIRSR605002-2","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16963079","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2I55","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PIRSR","id":"PIRSR605002-3","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16963079","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2I55","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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