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2I3U

Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors

Functional Information from GO Data
ChainGOidnamespacecontents
A0004725molecular_functionprotein tyrosine phosphatase activity
A0006470biological_processprotein dephosphorylation
A0016311biological_processdephosphorylation
Functional Information from PROSITE/UniProt
site_idPS00383
Number of Residues11
DetailsTYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGvgRTG
ChainResidueDetails
AVAL1902-GLY1912

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044, ECO:0000269|PubMed:17139078
ChainResidueDetails
ACYS1904

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING:
ChainResidueDetails
AASP1870

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ACYS1904
AGLN1948

Catalytic Information from CSA
site_idCSA1
Number of Residues5
DetailsAnnotated By Reference To The Literature 1ytw
ChainResidueDetails
AARG1910
ACYS1904
AASP1870
AHIS1903
ATHR1911

site_idCSA2
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ytw
ChainResidueDetails
AARG1910
ACYS1904
AASP1870
ATHR1911

229183

PDB entries from 2024-12-18

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