2I3U

Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation

Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGvgRTG

Chain	Residue	Details
A	VAL1902-GLY1912

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044, ECO:0000269|PubMed:17139078

Chain	Residue	Details
A	CYS1904

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	ASP1870

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	CYS1904
A	GLN1948

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 1ytw

Chain	Residue	Details
A	ARG1910
A	CYS1904
A	ASP1870
A	HIS1903
A	THR1911

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site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1ytw

Chain	Residue	Details
A	ARG1910
A	CYS1904
A	ASP1870
A	THR1911

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