2I3A

Crystal structure of N-Acetyl-gamma-Glutamyl-Phosphate Reductase (Rv1652) from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006526	biological_process	L-arginine biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0051287	molecular_function	NAD binding
A	0070401	molecular_function	NADP+ binding
B	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006526	biological_process	L-arginine biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0051287	molecular_function	NAD binding
B	0070401	molecular_function	NADP+ binding
C	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006526	biological_process	L-arginine biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0051287	molecular_function	NAD binding
C	0070401	molecular_function	NADP+ binding
D	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006526	biological_process	L-arginine biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0051287	molecular_function	NAD binding
D	0070401	molecular_function	NADP+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BTB A 1400

Chain	Residue
A	HIS32
A	ALA34
A	ASP37
A	ARG39
A	TRP339
A	PRO340
A	ASP343

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BTB B 1500

Chain	Residue
B	ASP37
B	ARG39
B	TRP339
B	PRO340
B	ASP343
B	HIS32
B	ALA34

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BTB C 1600

Chain	Residue
C	HIS32
C	ALA34
C	ASP37
C	ARG39
C	TRP339
C	ASP343

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BTB D 1700

Chain	Residue
D	HIS32
D	ALA34
D	ASP37
D	ARG39
D	ASP343

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Functional Information from PROSITE/UniProt

site_id	PS01224
Number of Residues	17
Details	ARGC N-acetyl-gamma-glutamyl-phosphate reductase active site. IAvPGCYPTAallALfP

Chain	Residue	Details
A	ILE153-PRO169

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00150

Chain	Residue	Details
A	CYS158
B	CYS158
C	CYS158
D	CYS158

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