2I26

Crystal structure analysis of the nurse shark new antigen receptor ancestral variable domain in complex with lysozyme

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0003796	molecular_function	lysozyme activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005737	cellular_component	cytoplasm
L	0005783	cellular_component	endoplasmic reticulum
L	0016231	molecular_function	beta-N-acetylglucosaminidase activity
L	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
L	0016998	biological_process	cell wall macromolecule catabolic process
L	0031640	biological_process	killing of cells of another organism
L	0042742	biological_process	defense response to bacterium
L	0042802	molecular_function	identical protein binding
L	0050829	biological_process	defense response to Gram-negative bacterium
L	0050830	biological_process	defense response to Gram-positive bacterium
L	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism
M	0003796	molecular_function	lysozyme activity
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0005737	cellular_component	cytoplasm
M	0005783	cellular_component	endoplasmic reticulum
M	0016231	molecular_function	beta-N-acetylglucosaminidase activity
M	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
M	0016998	biological_process	cell wall macromolecule catabolic process
M	0031640	biological_process	killing of cells of another organism
M	0042742	biological_process	defense response to bacterium
M	0042802	molecular_function	identical protein binding
M	0050829	biological_process	defense response to Gram-negative bacterium
M	0050830	biological_process	defense response to Gram-positive bacterium
M	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism
Q	0003796	molecular_function	lysozyme activity
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0005737	cellular_component	cytoplasm
Q	0005783	cellular_component	endoplasmic reticulum
Q	0016231	molecular_function	beta-N-acetylglucosaminidase activity
Q	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
Q	0016998	biological_process	cell wall macromolecule catabolic process
Q	0031640	biological_process	killing of cells of another organism
Q	0042742	biological_process	defense response to bacterium
Q	0042802	molecular_function	identical protein binding
Q	0050829	biological_process	defense response to Gram-negative bacterium
Q	0050830	biological_process	defense response to Gram-positive bacterium
Q	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 L 201

Chain	Residue
L	ARG125
L	GLY126
L	CYS127
L	ARG128
P	THR11

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 M 202

Chain	Residue
M	ARG125
M	GLY126
M	ARG128

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 Q 203

Chain	Residue
Q	GLY126
Q	CYS127
Q	ARG128
Q	ARG125

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 Q 204

Chain	Residue
M	ARG73
Q	ARG14
Q	HIS15

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 M 205

Chain	Residue
M	ALA11
M	ARG14
M	HIS15

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 Q 206

Chain	Residue
M	TYR20
Q	ARG125

---

Functional Information from PROSITE/UniProt

site_id	PS00128
Number of Residues	19
Details	GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC

Chain	Residue	Details
L	CYS76-CYS94

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE:

Chain	Residue	Details
L	GLU35
L	ASP52
M	GLU35
M	ASP52
Q	GLU35
Q	ASP52

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
L	ASP101
M	ASP101
Q	ASP101

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 132l

Chain	Residue	Details
L	GLU35
L	ASP52

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 132l

Chain	Residue	Details
M	GLU35
M	ASP52

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 132l

Chain	Residue	Details
Q	GLU35
Q	ASP52

---

site_id	MCSA1
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
L	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
L	ASN46
L	ASP48
L	SER50
L	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
L	ASN59

---

site_id	MCSA2
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
M	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
M	ASN46
M	ASP48
M	SER50
M	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
M	ASN59

---

site_id	MCSA3
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
Q	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
Q	ASN46
Q	ASP48
Q	SER50
Q	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
Q	ASN59

---