2HZV

NikR-operator DNA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0001046	molecular_function	core promoter sequence-specific DNA binding
A	0001217	molecular_function	DNA-binding transcription repressor activity
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005515	molecular_function	protein binding
A	0005667	cellular_component	transcription regulator complex
A	0006355	biological_process	regulation of DNA-templated transcription
A	0010045	biological_process	response to nickel cation
A	0016151	molecular_function	nickel cation binding
A	0032993	cellular_component	protein-DNA complex
A	0042802	molecular_function	identical protein binding
A	0043565	molecular_function	sequence-specific DNA binding
A	0046872	molecular_function	metal ion binding
A	2000143	biological_process	negative regulation of DNA-templated transcription initiation
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0001046	molecular_function	core promoter sequence-specific DNA binding
B	0001217	molecular_function	DNA-binding transcription repressor activity
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005515	molecular_function	protein binding
B	0005667	cellular_component	transcription regulator complex
B	0006355	biological_process	regulation of DNA-templated transcription
B	0010045	biological_process	response to nickel cation
B	0016151	molecular_function	nickel cation binding
B	0032993	cellular_component	protein-DNA complex
B	0042802	molecular_function	identical protein binding
B	0043565	molecular_function	sequence-specific DNA binding
B	0046872	molecular_function	metal ion binding
B	2000143	biological_process	negative regulation of DNA-templated transcription initiation
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0001046	molecular_function	core promoter sequence-specific DNA binding
C	0001217	molecular_function	DNA-binding transcription repressor activity
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005515	molecular_function	protein binding
C	0005667	cellular_component	transcription regulator complex
C	0006355	biological_process	regulation of DNA-templated transcription
C	0010045	biological_process	response to nickel cation
C	0016151	molecular_function	nickel cation binding
C	0032993	cellular_component	protein-DNA complex
C	0042802	molecular_function	identical protein binding
C	0043565	molecular_function	sequence-specific DNA binding
C	0046872	molecular_function	metal ion binding
C	2000143	biological_process	negative regulation of DNA-templated transcription initiation
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0001046	molecular_function	core promoter sequence-specific DNA binding
D	0001217	molecular_function	DNA-binding transcription repressor activity
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005515	molecular_function	protein binding
D	0005667	cellular_component	transcription regulator complex
D	0006355	biological_process	regulation of DNA-templated transcription
D	0010045	biological_process	response to nickel cation
D	0016151	molecular_function	nickel cation binding
D	0032993	cellular_component	protein-DNA complex
D	0042802	molecular_function	identical protein binding
D	0043565	molecular_function	sequence-specific DNA binding
D	0046872	molecular_function	metal ion binding
D	2000143	biological_process	negative regulation of DNA-templated transcription initiation
E	0000976	molecular_function	transcription cis-regulatory region binding
E	0001046	molecular_function	core promoter sequence-specific DNA binding
E	0001217	molecular_function	DNA-binding transcription repressor activity
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0005515	molecular_function	protein binding
E	0005667	cellular_component	transcription regulator complex
E	0006355	biological_process	regulation of DNA-templated transcription
E	0010045	biological_process	response to nickel cation
E	0016151	molecular_function	nickel cation binding
E	0032993	cellular_component	protein-DNA complex
E	0042802	molecular_function	identical protein binding
E	0043565	molecular_function	sequence-specific DNA binding
E	0046872	molecular_function	metal ion binding
E	2000143	biological_process	negative regulation of DNA-templated transcription initiation
F	0000976	molecular_function	transcription cis-regulatory region binding
F	0001046	molecular_function	core promoter sequence-specific DNA binding
F	0001217	molecular_function	DNA-binding transcription repressor activity
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0005515	molecular_function	protein binding
F	0005667	cellular_component	transcription regulator complex
F	0006355	biological_process	regulation of DNA-templated transcription
F	0010045	biological_process	response to nickel cation
F	0016151	molecular_function	nickel cation binding
F	0032993	cellular_component	protein-DNA complex
F	0042802	molecular_function	identical protein binding
F	0043565	molecular_function	sequence-specific DNA binding
F	0046872	molecular_function	metal ion binding
F	2000143	biological_process	negative regulation of DNA-templated transcription initiation
G	0000976	molecular_function	transcription cis-regulatory region binding
G	0001046	molecular_function	core promoter sequence-specific DNA binding
G	0001217	molecular_function	DNA-binding transcription repressor activity
G	0003677	molecular_function	DNA binding
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0005515	molecular_function	protein binding
G	0005667	cellular_component	transcription regulator complex
G	0006355	biological_process	regulation of DNA-templated transcription
G	0010045	biological_process	response to nickel cation
G	0016151	molecular_function	nickel cation binding
G	0032993	cellular_component	protein-DNA complex
G	0042802	molecular_function	identical protein binding
G	0043565	molecular_function	sequence-specific DNA binding
G	0046872	molecular_function	metal ion binding
G	2000143	biological_process	negative regulation of DNA-templated transcription initiation
H	0000976	molecular_function	transcription cis-regulatory region binding
H	0001046	molecular_function	core promoter sequence-specific DNA binding
H	0001217	molecular_function	DNA-binding transcription repressor activity
H	0003677	molecular_function	DNA binding
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0005515	molecular_function	protein binding
H	0005667	cellular_component	transcription regulator complex
H	0006355	biological_process	regulation of DNA-templated transcription
H	0010045	biological_process	response to nickel cation
H	0016151	molecular_function	nickel cation binding
H	0032993	cellular_component	protein-DNA complex
H	0042802	molecular_function	identical protein binding
H	0043565	molecular_function	sequence-specific DNA binding
H	0046872	molecular_function	metal ion binding
H	2000143	biological_process	negative regulation of DNA-templated transcription initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NI D 301

Chain	Residue
B	HIS87
B	HIS89
B	CYS95
D	HIS76

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI A 302

Chain	Residue
C	HIS76
A	HIS87
A	VAL88
A	HIS89
A	CYS95
C	VAL72

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI C 303

Chain	Residue
A	HIS76
C	HIS87
C	VAL88
C	HIS89
C	CYS95

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI D 304

Chain	Residue
B	VAL72
B	HIS76
D	HIS87
D	HIS89
D	CYS95

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI F 305

Chain	Residue
F	HIS87
F	HIS89
F	CYS95
H	VAL72
H	HIS76

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI E 306

Chain	Residue
E	HIS87
E	VAL88
E	HIS89
E	CYS95
G	VAL72
G	HIS76

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI G 307

Chain	Residue
E	VAL72
E	HIS76
G	HIS87
G	HIS89
G	CYS95

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI H 308

Chain	Residue
F	VAL72
F	HIS76
H	HIS87
H	HIS89
H	CYS95

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K A 401

Chain	Residue
A	GLU30
A	ASP34
B	ILE116
B	GLN118
B	VAL121

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 402

Chain	Residue
C	GLU30
C	ASP34
D	ILE116
D	ALA117
D	GLN118
D	VAL121

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 403

Chain	Residue
E	GLU30
E	ASP34
F	ILE116
F	ALA117
F	GLN118
F	VAL121

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K G 404

Chain	Residue
G	GLU30
G	ASP34
H	ILE116
H	ALA117
H	GLN118
H	VAL121

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K H 405

Chain	Residue
F	HIS89
H	HIS79
H	SER82

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K E 406

Chain	Residue
E	HIS79
E	SER82
G	HIS89

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K G 407

Chain	Residue
E	HIS89
G	HIS79
G	SER82

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K F 408

Chain	Residue
F	HIS79
F	SER82
H	HIS89

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K A 409

Chain	Residue
A	HIS79
A	SER82
C	HIS89

---

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K B 410

Chain	Residue
B	HIS79
B	SER82
D	HIS89

---

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K C 411

Chain	Residue
A	HIS89
C	HIS79
C	SER82

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	BINDING:

Chain	Residue	Details
A	HIS76
C	HIS87
C	HIS89
C	CYS95
D	HIS76
D	HIS87
D	HIS89
D	CYS95
E	HIS76
E	HIS87
E	HIS89
A	HIS87
E	CYS95
F	HIS76
F	HIS87
F	HIS89
F	CYS95
G	HIS76
G	HIS87
G	HIS89
G	CYS95
H	HIS76
A	HIS89
H	HIS87
H	HIS89
H	CYS95
A	CYS95
B	HIS76
B	HIS87
B	HIS89
B	CYS95
C	HIS76

---