2HZM

Structure of the Mediator head subcomplex Med18/20

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001094	molecular_function	TFIID-class transcription factor complex binding
A	0003712	molecular_function	transcription coregulator activity
A	0003713	molecular_function	transcription coactivator activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0006351	biological_process	DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0010688	biological_process	negative regulation of ribosomal protein gene transcription by RNA polymerase II
A	0016592	cellular_component	mediator complex
A	0019904	molecular_function	protein domain specific binding
A	0031669	biological_process	cellular response to nutrient levels
A	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
A	0032991	cellular_component	protein-containing complex
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0051123	biological_process	RNA polymerase II preinitiation complex assembly
A	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
A	0070847	cellular_component	core mediator complex
B	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
B	0001113	biological_process	transcription open complex formation at RNA polymerase II promoter
B	0003712	molecular_function	transcription coregulator activity
B	0003713	molecular_function	transcription coactivator activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0006351	biological_process	DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006369	biological_process	termination of RNA polymerase II transcription
B	0016592	cellular_component	mediator complex
B	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
B	0034605	biological_process	cellular response to heat
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0051123	biological_process	RNA polymerase II preinitiation complex assembly
B	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
B	0070847	cellular_component	core mediator complex
C	0001094	molecular_function	TFIID-class transcription factor complex binding
C	0003712	molecular_function	transcription coregulator activity
C	0003713	molecular_function	transcription coactivator activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0006351	biological_process	DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0010688	biological_process	negative regulation of ribosomal protein gene transcription by RNA polymerase II
C	0016592	cellular_component	mediator complex
C	0019904	molecular_function	protein domain specific binding
C	0031669	biological_process	cellular response to nutrient levels
C	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
C	0032991	cellular_component	protein-containing complex
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0051123	biological_process	RNA polymerase II preinitiation complex assembly
C	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
C	0070847	cellular_component	core mediator complex
D	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
D	0001113	biological_process	transcription open complex formation at RNA polymerase II promoter
D	0003712	molecular_function	transcription coregulator activity
D	0003713	molecular_function	transcription coactivator activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0006351	biological_process	DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006369	biological_process	termination of RNA polymerase II transcription
D	0016592	cellular_component	mediator complex
D	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
D	0034605	biological_process	cellular response to heat
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0051123	biological_process	RNA polymerase II preinitiation complex assembly
D	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
D	0070847	cellular_component	core mediator complex
E	0001094	molecular_function	TFIID-class transcription factor complex binding
E	0003712	molecular_function	transcription coregulator activity
E	0003713	molecular_function	transcription coactivator activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0006351	biological_process	DNA-templated transcription
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0010688	biological_process	negative regulation of ribosomal protein gene transcription by RNA polymerase II
E	0016592	cellular_component	mediator complex
E	0019904	molecular_function	protein domain specific binding
E	0031669	biological_process	cellular response to nutrient levels
E	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
E	0032991	cellular_component	protein-containing complex
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0051123	biological_process	RNA polymerase II preinitiation complex assembly
E	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
E	0070847	cellular_component	core mediator complex
F	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
F	0001113	biological_process	transcription open complex formation at RNA polymerase II promoter
F	0003712	molecular_function	transcription coregulator activity
F	0003713	molecular_function	transcription coactivator activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0006351	biological_process	DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006369	biological_process	termination of RNA polymerase II transcription
F	0016592	cellular_component	mediator complex
F	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
F	0034605	biological_process	cellular response to heat
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0051123	biological_process	RNA polymerase II preinitiation complex assembly
F	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
F	0070847	cellular_component	core mediator complex
G	0001094	molecular_function	TFIID-class transcription factor complex binding
G	0003712	molecular_function	transcription coregulator activity
G	0003713	molecular_function	transcription coactivator activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0006351	biological_process	DNA-templated transcription
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0010688	biological_process	negative regulation of ribosomal protein gene transcription by RNA polymerase II
G	0016592	cellular_component	mediator complex
G	0019904	molecular_function	protein domain specific binding
G	0031669	biological_process	cellular response to nutrient levels
G	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
G	0032991	cellular_component	protein-containing complex
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0051123	biological_process	RNA polymerase II preinitiation complex assembly
G	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
G	0070847	cellular_component	core mediator complex
H	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
H	0001113	biological_process	transcription open complex formation at RNA polymerase II promoter
H	0003712	molecular_function	transcription coregulator activity
H	0003713	molecular_function	transcription coactivator activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0006351	biological_process	DNA-templated transcription
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0006369	biological_process	termination of RNA polymerase II transcription
H	0016592	cellular_component	mediator complex
H	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
H	0034605	biological_process	cellular response to heat
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0051123	biological_process	RNA polymerase II preinitiation complex assembly
H	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
H	0070847	cellular_component	core mediator complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 211

Chain	Residue
A	ARG32
A	ASP33
A	HIS64
A	THR129
A	ARG138
A	HOH243

---