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2HRB

Crystal Structure of human Carbonyl Reductase 3, complexed with NADP+

Functional Information from GO Data
ChainGOidnamespacecontents
A0000253molecular_function3-keto sterol reductase activity
A0004090molecular_functioncarbonyl reductase (NADPH) activity
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006805biological_processxenobiotic metabolic process
A0008753molecular_functionNADPH dehydrogenase (quinone) activity
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0042376biological_processphylloquinone catabolic process
A0050890biological_processcognition
A0070402molecular_functionNADPH binding
Functional Information from PDB Data
site_idAC1
Number of Residues31
DetailsBINDING SITE FOR RESIDUE NAP A 1001
ChainResidue
AGLY12
AILE64
AASP65
AASN90
AALA91
AALA92
AILE138
ASER139
ATYR194
ALYS198
APRO228
AASN14
AGLY229
AVAL231
AASP239
AGOL2001
AHOH2006
AHOH2012
AHOH2017
AHOH2036
AHOH2060
AHOH2076
AARG15
AHOH2139
AHOH2169
AGLY16
AILE17
AARG38
AARG42
ALEU62
AASP63

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 2001
ChainResidue
AALA92
AVAL93
AALA94
ATYR194
ANAP1001
AHOH2169

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 2002
ChainResidue
AHIS159
AARG206
AASN276
ATRP277
AHOH2130
AHOH2135
AHOH2219

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL A 2003
ChainResidue
AARG38
AASP39
AVAL40
AALA41
AARG78
AGLY82
APRO127
AILE128
AHOH2030
AHOH2108

Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. NevheregwpNspYGVSKLGVtVLSrILA
ChainResidueDetails
AASN181-ALA209

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001
ChainResidueDetails
AVAL196

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|Ref.13
ChainResidueDetails
AGLY12
AVAL40
AASP65
AALA92
AVAL196
AILE241

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLN142

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P48758
ChainResidueDetails
AASP32

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PDB entries from 2024-04-24

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