2HPC

Crystal structure of fragment D from Human Fibrinogen Complexed with Gly-Pro-Arg-Pro-amide.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005102	molecular_function	signaling receptor binding
A	0005577	cellular_component	fibrinogen complex
A	0007596	biological_process	blood coagulation
A	0030168	biological_process	platelet activation
A	0051258	biological_process	protein polymerization
B	0005102	molecular_function	signaling receptor binding
B	0005577	cellular_component	fibrinogen complex
B	0007596	biological_process	blood coagulation
B	0030168	biological_process	platelet activation
B	0051258	biological_process	protein polymerization
C	0005102	molecular_function	signaling receptor binding
C	0005577	cellular_component	fibrinogen complex
C	0007596	biological_process	blood coagulation
C	0030168	biological_process	platelet activation
C	0051258	biological_process	protein polymerization
D	0005102	molecular_function	signaling receptor binding
D	0005577	cellular_component	fibrinogen complex
D	0007596	biological_process	blood coagulation
D	0030168	biological_process	platelet activation
D	0051258	biological_process	protein polymerization
E	0005102	molecular_function	signaling receptor binding
E	0005577	cellular_component	fibrinogen complex
E	0007596	biological_process	blood coagulation
E	0030168	biological_process	platelet activation
E	0051258	biological_process	protein polymerization
F	0005102	molecular_function	signaling receptor binding
F	0005577	cellular_component	fibrinogen complex
F	0007596	biological_process	blood coagulation
F	0030168	biological_process	platelet activation
F	0051258	biological_process	protein polymerization
G	0005102	molecular_function	signaling receptor binding
G	0005577	cellular_component	fibrinogen complex
G	0007596	biological_process	blood coagulation
G	0030168	biological_process	platelet activation
G	0051258	biological_process	protein polymerization
H	0005102	molecular_function	signaling receptor binding
H	0005577	cellular_component	fibrinogen complex
H	0007596	biological_process	blood coagulation
H	0030168	biological_process	platelet activation
H	0051258	biological_process	protein polymerization
I	0005102	molecular_function	signaling receptor binding
I	0005577	cellular_component	fibrinogen complex
I	0007596	biological_process	blood coagulation
I	0030168	biological_process	platelet activation
I	0051258	biological_process	protein polymerization
J	0005102	molecular_function	signaling receptor binding
J	0005577	cellular_component	fibrinogen complex
J	0007596	biological_process	blood coagulation
J	0030168	biological_process	platelet activation
J	0051258	biological_process	protein polymerization
K	0005102	molecular_function	signaling receptor binding
K	0005577	cellular_component	fibrinogen complex
K	0007596	biological_process	blood coagulation
K	0030168	biological_process	platelet activation
K	0051258	biological_process	protein polymerization
L	0005102	molecular_function	signaling receptor binding
L	0005577	cellular_component	fibrinogen complex
L	0007596	biological_process	blood coagulation
L	0030168	biological_process	platelet activation
L	0051258	biological_process	protein polymerization

Functional Information from PROSITE/UniProt

site_id	PS00514
Number of Residues	13
Details	FIBRINOGEN_C_1 Fibrinogen C-terminal domain signature. WWYnrChaAnpNG

Chain	Residue	Details
B	TRP402-GLY414
C	TRP334-GLY346

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:10074346, ECO:0000269|PubMed:19296670, ECO:0000269|PubMed:9016719, ECO:0000269|PubMed:9207064, ECO:0000269|PubMed:9333233, ECO:0000269|PubMed:9628725, ECO:0007744|PDB:1FID

Chain	Residue	Details
C	ASP318
I	ASP320
I	PHE322
I	GLY324
L	ASP318
L	ASP320
L	PHE322
L	GLY324
C	ASP320
C	PHE322
C	GLY324
F	ASP318
F	ASP320
F	PHE322
F	GLY324
I	ASP318

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; in variant Asahi

Chain	Residue	Details
C	ASN308
F	ASN308
I	ASN308
L	ASN308

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-432)

Chain	Residue	Details
C	GLN398
F	GLN398
I	GLN398
L	GLN398

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site_id	SWS_FT_FI4
Number of Residues	8
Details	CROSSLNK: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-424)

Chain	Residue	Details
C	LYS406
F	LYS406
I	LYS406
L	LYS406

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