2HLZ
Crystal Structure of human ketohexokinase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004454 | molecular_function | ketohexokinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006000 | biological_process | fructose metabolic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032868 | biological_process | response to insulin |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046835 | biological_process | carbohydrate phosphorylation |
| A | 0070061 | molecular_function | fructose binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070873 | biological_process | regulation of glycogen metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004454 | molecular_function | ketohexokinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006000 | biological_process | fructose metabolic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032868 | biological_process | response to insulin |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046835 | biological_process | carbohydrate phosphorylation |
| B | 0070061 | molecular_function | fructose binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070873 | biological_process | regulation of glycogen metabolic process |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004454 | molecular_function | ketohexokinase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006000 | biological_process | fructose metabolic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0032868 | biological_process | response to insulin |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0046835 | biological_process | carbohydrate phosphorylation |
| C | 0070061 | molecular_function | fructose binding |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0070873 | biological_process | regulation of glycogen metabolic process |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004454 | molecular_function | ketohexokinase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006000 | biological_process | fructose metabolic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0032868 | biological_process | response to insulin |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0046835 | biological_process | carbohydrate phosphorylation |
| D | 0070061 | molecular_function | fructose binding |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0070873 | biological_process | regulation of glycogen metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX A 701 |
| Chain | Residue |
| A | ALA256 |
| A | GLY257 |
| A | HOH375 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX B 702 |
| Chain | Residue |
| B | THR253 |
| B | ALA256 |
| B | GLY257 |
| B | HOH369 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX C 703 |
| Chain | Residue |
| C | GLY255 |
| C | GLY257 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX D 704 |
| Chain | Residue |
| D | ARG108 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX B 706 |
| Chain | Residue |
| B | HIS156 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 707 |
| Chain | Residue |
| A | ALA143 |
| A | SER144 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 708 |
| Chain | Residue |
| A | ARG31 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX D 709 |
| Chain | Residue |
| D | VAL68 |
| D | ARG115 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX B 710 |
| Chain | Residue |
| B | ARG272 |
| B | SER273 |
| B | GLU276 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX B 711 |
| Chain | Residue |
| B | ALA226 |
| B | GLY229 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 712 |
| Chain | Residue |
| A | ARG115 |
| A | HOH316 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 713 |
| Chain | Residue |
| A | ALA226 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX D 714 |
| Chain | Residue |
| D | HIS156 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 715 |
| Chain | Residue |
| A | ILE96 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX C 716 |
| Chain | Residue |
| B | HOH513 |
| C | ILE96 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX D 717 |
| Chain | Residue |
| D | ALA226 |
| D | GLY229 |
| site_id | BC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX B 718 |
| Chain | Residue |
| B | ARG115 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX D 719 |
| Chain | Residue |
| B | GLU227 |
| D | SER203 |
| D | GLU205 |
| site_id | CC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX B 721 |
| Chain | Residue |
| B | ALA143 |
| B | GLU178 |
| site_id | CC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX C 722 |
| Chain | Residue |
| C | HIS156 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX C 723 |
| Chain | Residue |
| C | ALA226 |
| C | GLY229 |
| site_id | CC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX C 724 |
| Chain | Residue |
| C | ARG115 |
| site_id | CC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 726 |
| Chain | Residue |
| A | ARG77 |
| C | LYS127 |
| site_id | CC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX D 727 |
| Chain | Residue |
| D | SER273 |
| site_id | CC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX D 728 |
| Chain | Residue |
| D | SER267 |
| site_id | CC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX C 729 |
| Chain | Residue |
| D | HIS198 |
| site_id | CC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX C 730 |
| Chain | Residue |
| C | ASP15 |
| C | GLY41 |
| site_id | DC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX B 731 |
| Chain | Residue |
| B | ASP70 |
| D | ARG77 |
| site_id | DC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 732 |
| Chain | Residue |
| A | SER273 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19237742","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HW1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"2HW1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19237742","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2HW1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1lio |
| Chain | Residue | Details |
| A | ASP258 | |
| A | ARG108 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1lio |
| Chain | Residue | Details |
| B | ASP258 | |
| B | ARG108 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1lio |
| Chain | Residue | Details |
| C | ASP258 | |
| C | ARG108 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1lio |
| Chain | Residue | Details |
| D | ASP258 | |
| D | ARG108 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1lio |
| Chain | Residue | Details |
| A | GLY257 | |
| A | GLY255 | |
| A | ASP258 | |
| A | ALA256 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1lio |
| Chain | Residue | Details |
| B | GLY257 | |
| B | GLY255 | |
| B | ASP258 | |
| B | ALA256 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1lio |
| Chain | Residue | Details |
| C | GLY257 | |
| C | GLY255 | |
| C | ASP258 | |
| C | ALA256 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1lio |
| Chain | Residue | Details |
| D | GLY257 | |
| D | GLY255 | |
| D | ASP258 | |
| D | ALA256 |
