2HLZ
Crystal Structure of human ketohexokinase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004454 | molecular_function | ketohexokinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006000 | biological_process | fructose metabolic process |
A | 0006796 | biological_process | phosphate-containing compound metabolic process |
A | 0009744 | biological_process | response to sucrose |
A | 0009749 | biological_process | response to glucose |
A | 0009750 | biological_process | response to fructose |
A | 0010043 | biological_process | response to zinc ion |
A | 0016301 | molecular_function | kinase activity |
A | 0032868 | biological_process | response to insulin |
A | 0046835 | biological_process | carbohydrate phosphorylation |
A | 0070062 | cellular_component | extracellular exosome |
A | 0070873 | biological_process | regulation of glycogen metabolic process |
B | 0004454 | molecular_function | ketohexokinase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006000 | biological_process | fructose metabolic process |
B | 0006796 | biological_process | phosphate-containing compound metabolic process |
B | 0009744 | biological_process | response to sucrose |
B | 0009749 | biological_process | response to glucose |
B | 0009750 | biological_process | response to fructose |
B | 0010043 | biological_process | response to zinc ion |
B | 0016301 | molecular_function | kinase activity |
B | 0032868 | biological_process | response to insulin |
B | 0046835 | biological_process | carbohydrate phosphorylation |
B | 0070062 | cellular_component | extracellular exosome |
B | 0070873 | biological_process | regulation of glycogen metabolic process |
C | 0004454 | molecular_function | ketohexokinase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005524 | molecular_function | ATP binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006000 | biological_process | fructose metabolic process |
C | 0006796 | biological_process | phosphate-containing compound metabolic process |
C | 0009744 | biological_process | response to sucrose |
C | 0009749 | biological_process | response to glucose |
C | 0009750 | biological_process | response to fructose |
C | 0010043 | biological_process | response to zinc ion |
C | 0016301 | molecular_function | kinase activity |
C | 0032868 | biological_process | response to insulin |
C | 0046835 | biological_process | carbohydrate phosphorylation |
C | 0070062 | cellular_component | extracellular exosome |
C | 0070873 | biological_process | regulation of glycogen metabolic process |
D | 0004454 | molecular_function | ketohexokinase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005524 | molecular_function | ATP binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006000 | biological_process | fructose metabolic process |
D | 0006796 | biological_process | phosphate-containing compound metabolic process |
D | 0009744 | biological_process | response to sucrose |
D | 0009749 | biological_process | response to glucose |
D | 0009750 | biological_process | response to fructose |
D | 0010043 | biological_process | response to zinc ion |
D | 0016301 | molecular_function | kinase activity |
D | 0032868 | biological_process | response to insulin |
D | 0046835 | biological_process | carbohydrate phosphorylation |
D | 0070062 | cellular_component | extracellular exosome |
D | 0070873 | biological_process | regulation of glycogen metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE UNX A 701 |
Chain | Residue |
A | ALA256 |
A | GLY257 |
A | HOH375 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE UNX B 702 |
Chain | Residue |
B | THR253 |
B | ALA256 |
B | GLY257 |
B | HOH369 |
site_id | AC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE UNX C 703 |
Chain | Residue |
C | GLY255 |
C | GLY257 |
site_id | AC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE UNX D 704 |
Chain | Residue |
D | ARG108 |
site_id | AC5 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE UNX B 706 |
Chain | Residue |
B | HIS156 |
site_id | AC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE UNX A 707 |
Chain | Residue |
A | ALA143 |
A | SER144 |
site_id | AC7 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE UNX A 708 |
Chain | Residue |
A | ARG31 |
site_id | AC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE UNX D 709 |
Chain | Residue |
D | VAL68 |
D | ARG115 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE UNX B 710 |
Chain | Residue |
B | ARG272 |
B | SER273 |
B | GLU276 |
site_id | BC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE UNX B 711 |
Chain | Residue |
B | ALA226 |
B | GLY229 |
site_id | BC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE UNX A 712 |
Chain | Residue |
A | ARG115 |
A | HOH316 |
site_id | BC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE UNX A 713 |
Chain | Residue |
A | ALA226 |
site_id | BC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE UNX D 714 |
Chain | Residue |
D | HIS156 |
site_id | BC5 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE UNX A 715 |
Chain | Residue |
A | ILE96 |
site_id | BC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE UNX C 716 |
Chain | Residue |
B | HOH513 |
C | ILE96 |
site_id | BC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE UNX D 717 |
Chain | Residue |
D | ALA226 |
D | GLY229 |
site_id | BC8 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE UNX B 718 |
Chain | Residue |
B | ARG115 |
site_id | BC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE UNX D 719 |
Chain | Residue |
B | GLU227 |
D | SER203 |
D | GLU205 |
site_id | CC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE UNX B 721 |
Chain | Residue |
B | ALA143 |
B | GLU178 |
site_id | CC2 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE UNX C 722 |
Chain | Residue |
C | HIS156 |
site_id | CC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE UNX C 723 |
Chain | Residue |
C | ALA226 |
C | GLY229 |
site_id | CC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE UNX C 724 |
Chain | Residue |
C | ARG115 |
site_id | CC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE UNX A 726 |
Chain | Residue |
A | ARG77 |
C | LYS127 |
site_id | CC6 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE UNX D 727 |
Chain | Residue |
D | SER273 |
site_id | CC7 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE UNX D 728 |
Chain | Residue |
D | SER267 |
site_id | CC8 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE UNX C 729 |
Chain | Residue |
D | HIS198 |
site_id | CC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE UNX C 730 |
Chain | Residue |
C | ASP15 |
C | GLY41 |
site_id | DC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE UNX B 731 |
Chain | Residue |
B | ASP70 |
D | ARG77 |
site_id | DC2 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE UNX A 732 |
Chain | Residue |
A | SER273 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:19237742, ECO:0007744|PDB:2HW1 |
Chain | Residue | Details |
A | ASP15 | |
B | ASP15 | |
C | ASP15 | |
D | ASP15 |
site_id | SWS_FT_FI2 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0007744|PDB:2HW1 |
Chain | Residue | Details |
A | GLY41 | |
C | ASN42 | |
C | ASN45 | |
C | ASP258 | |
D | GLY41 | |
D | ASN42 | |
D | ASN45 | |
D | ASP258 | |
A | ASN42 | |
A | ASN45 | |
A | ASP258 | |
B | GLY41 | |
B | ASN42 | |
B | ASN45 | |
B | ASP258 | |
C | GLY41 |
site_id | SWS_FT_FI3 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000305|PubMed:19237742, ECO:0007744|PDB:2HW1 |
Chain | Residue | Details |
A | ARG108 | |
D | ARG108 | |
D | ALA226 | |
D | GLY255 | |
A | ALA226 | |
A | GLY255 | |
B | ARG108 | |
B | ALA226 | |
B | GLY255 | |
C | ARG108 | |
C | ALA226 | |
C | GLY255 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1lio |
Chain | Residue | Details |
A | ASP258 | |
A | ARG108 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1lio |
Chain | Residue | Details |
B | ASP258 | |
B | ARG108 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1lio |
Chain | Residue | Details |
C | ASP258 | |
C | ARG108 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1lio |
Chain | Residue | Details |
D | ASP258 | |
D | ARG108 |
site_id | CSA5 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1lio |
Chain | Residue | Details |
A | GLY257 | |
A | GLY255 | |
A | ASP258 | |
A | ALA256 |
site_id | CSA6 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1lio |
Chain | Residue | Details |
B | GLY257 | |
B | GLY255 | |
B | ASP258 | |
B | ALA256 |
site_id | CSA7 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1lio |
Chain | Residue | Details |
C | GLY257 | |
C | GLY255 | |
C | ASP258 | |
C | ALA256 |
site_id | CSA8 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1lio |
Chain | Residue | Details |
D | GLY257 | |
D | GLY255 | |
D | ASP258 | |
D | ALA256 |