Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2HI9

Crystal Structure of human native protein C inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001972	molecular_function	retinoic acid binding
A	0002020	molecular_function	protease binding
A	0002080	cellular_component	acrosomal membrane
A	0004867	molecular_function	serine-type endopeptidase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005539	molecular_function	glycosaminoglycan binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006869	biological_process	lipid transport
A	0007283	biological_process	spermatogenesis
A	0007338	biological_process	single fertilization
A	0007342	biological_process	fusion of sperm to egg plasma membrane involved in single fertilization
A	0008201	molecular_function	heparin binding
A	0009897	cellular_component	external side of plasma membrane
A	0010466	biological_process	negative regulation of peptidase activity
A	0016020	cellular_component	membrane
A	0031091	cellular_component	platelet alpha granule
A	0031094	cellular_component	platelet dense tubular network
A	0031210	molecular_function	phosphatidylcholine binding
A	0032190	molecular_function	acrosin binding
A	0032991	cellular_component	protein-containing complex
A	0036024	cellular_component	protein C inhibitor-TMPRSS7 complex
A	0036025	cellular_component	protein C inhibitor-TMPRSS11E complex
A	0036026	cellular_component	protein C inhibitor-PLAT complex
A	0036027	cellular_component	protein C inhibitor-PLAU complex
A	0036028	cellular_component	protein C inhibitor-thrombin complex
A	0036029	cellular_component	protein C inhibitor-KLK3 complex
A	0036030	cellular_component	protein C inhibitor-plasma kallikrein complex
A	0051346	biological_process	negative regulation of hydrolase activity
A	0062023	cellular_component	collagen-containing extracellular matrix
A	0070062	cellular_component	extracellular exosome
A	0097181	cellular_component	protein C inhibitor-coagulation factor V complex
A	0097182	cellular_component	protein C inhibitor-coagulation factor Xa complex
A	0097183	cellular_component	protein C inhibitor-coagulation factor XI complex
B	0001972	molecular_function	retinoic acid binding
B	0002020	molecular_function	protease binding
B	0002080	cellular_component	acrosomal membrane
B	0004867	molecular_function	serine-type endopeptidase inhibitor activity
B	0005515	molecular_function	protein binding
B	0005539	molecular_function	glycosaminoglycan binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006869	biological_process	lipid transport
B	0007283	biological_process	spermatogenesis
B	0007338	biological_process	single fertilization
B	0007342	biological_process	fusion of sperm to egg plasma membrane involved in single fertilization
B	0008201	molecular_function	heparin binding
B	0009897	cellular_component	external side of plasma membrane
B	0010466	biological_process	negative regulation of peptidase activity
B	0016020	cellular_component	membrane
B	0031091	cellular_component	platelet alpha granule
B	0031094	cellular_component	platelet dense tubular network
B	0031210	molecular_function	phosphatidylcholine binding
B	0032190	molecular_function	acrosin binding
B	0032991	cellular_component	protein-containing complex
B	0036024	cellular_component	protein C inhibitor-TMPRSS7 complex
B	0036025	cellular_component	protein C inhibitor-TMPRSS11E complex
B	0036026	cellular_component	protein C inhibitor-PLAT complex
B	0036027	cellular_component	protein C inhibitor-PLAU complex
B	0036028	cellular_component	protein C inhibitor-thrombin complex
B	0036029	cellular_component	protein C inhibitor-KLK3 complex
B	0036030	cellular_component	protein C inhibitor-plasma kallikrein complex
B	0051346	biological_process	negative regulation of hydrolase activity
B	0062023	cellular_component	collagen-containing extracellular matrix
B	0070062	cellular_component	extracellular exosome
B	0097181	cellular_component	protein C inhibitor-coagulation factor V complex
B	0097182	cellular_component	protein C inhibitor-coagulation factor Xa complex
B	0097183	cellular_component	protein C inhibitor-coagulation factor XI complex
C	0001972	molecular_function	retinoic acid binding
C	0002020	molecular_function	protease binding
C	0002080	cellular_component	acrosomal membrane
C	0004867	molecular_function	serine-type endopeptidase inhibitor activity
C	0005515	molecular_function	protein binding
C	0005539	molecular_function	glycosaminoglycan binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006869	biological_process	lipid transport
C	0007283	biological_process	spermatogenesis
C	0007338	biological_process	single fertilization
C	0007342	biological_process	fusion of sperm to egg plasma membrane involved in single fertilization
C	0008201	molecular_function	heparin binding
C	0009897	cellular_component	external side of plasma membrane
C	0010466	biological_process	negative regulation of peptidase activity
C	0016020	cellular_component	membrane
C	0031091	cellular_component	platelet alpha granule
C	0031094	cellular_component	platelet dense tubular network
C	0031210	molecular_function	phosphatidylcholine binding
C	0032190	molecular_function	acrosin binding
C	0032991	cellular_component	protein-containing complex
C	0036024	cellular_component	protein C inhibitor-TMPRSS7 complex
C	0036025	cellular_component	protein C inhibitor-TMPRSS11E complex
C	0036026	cellular_component	protein C inhibitor-PLAT complex
C	0036027	cellular_component	protein C inhibitor-PLAU complex
C	0036028	cellular_component	protein C inhibitor-thrombin complex
C	0036029	cellular_component	protein C inhibitor-KLK3 complex
C	0036030	cellular_component	protein C inhibitor-plasma kallikrein complex
C	0051346	biological_process	negative regulation of hydrolase activity
C	0062023	cellular_component	collagen-containing extracellular matrix
C	0070062	cellular_component	extracellular exosome
C	0097181	cellular_component	protein C inhibitor-coagulation factor V complex
C	0097182	cellular_component	protein C inhibitor-coagulation factor Xa complex
C	0097183	cellular_component	protein C inhibitor-coagulation factor XI complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CIT A 1001

Chain	Residue
A	TYR225
A	LEU227
A	ARG229
A	ARG234
A	ARG278
A	GLN361
A	HOH1091

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CIT B 1002

Chain	Residue
B	ARG229
B	ARG234
B	ARG278
B	GLN361
B	TYR225
B	LEU227

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CIT C 1003

Chain	Residue
C	TYR225
C	LEU227
C	ARG229
C	ARG234
C	ARG278
C	GLN361

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 2001

Chain	Residue
B	SER146
B	ASN171
B	LEU172

Functional Information from PROSITE/UniProt

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. LVFNRPFLMfI

Chain	Residue	Details
A	LEU363-ILE373

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	SITE: Reactive bond

Chain	Residue	Details
A	ARG354
B	ARG354
C	ARG354

site_id	SWS_FT_FI2
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:14760718, ECO:0000269\|PubMed:18467335

Chain	Residue	Details
A	ASN230
B	ASN230
C	ASN230

site_id	SWS_FT_FI3
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12575940, ECO:0000269\|PubMed:16335952, ECO:0000269\|PubMed:18467335

Chain	Residue	Details
A	ASN243
B	ASN243
C	ASN243

site_id	SWS_FT_FI4
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:16335952, ECO:0000269\|PubMed:18467335

Chain	Residue	Details
A	ASN319
B	ASN319
C	ASN319

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)