2HHJ
Human bisphosphoglycerate mutase complexed with 2,3-bisphosphoglycerate (15 days)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004082 | molecular_function | bisphosphoglycerate mutase activity |
A | 0004619 | molecular_function | phosphoglycerate mutase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005829 | cellular_component | cytosol |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0006096 | biological_process | glycolytic process |
A | 0006753 | biological_process | nucleoside phosphate metabolic process |
A | 0007585 | biological_process | respiratory gaseous exchange by respiratory system |
A | 0015671 | biological_process | oxygen transport |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016853 | molecular_function | isomerase activity |
A | 0016868 | molecular_function | intramolecular phosphotransferase activity |
A | 0033554 | biological_process | cellular response to stress |
A | 0042832 | biological_process | defense response to protozoan |
A | 0046538 | molecular_function | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity |
A | 0048821 | biological_process | erythrocyte development |
A | 0060856 | biological_process | establishment of blood-brain barrier |
A | 0070062 | cellular_component | extracellular exosome |
A | 0150076 | biological_process | neuroinflammatory response |
A | 1901136 | biological_process | carbohydrate derivative catabolic process |
B | 0003824 | molecular_function | catalytic activity |
B | 0004082 | molecular_function | bisphosphoglycerate mutase activity |
B | 0004619 | molecular_function | phosphoglycerate mutase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005829 | cellular_component | cytosol |
B | 0005975 | biological_process | carbohydrate metabolic process |
B | 0006096 | biological_process | glycolytic process |
B | 0006753 | biological_process | nucleoside phosphate metabolic process |
B | 0007585 | biological_process | respiratory gaseous exchange by respiratory system |
B | 0015671 | biological_process | oxygen transport |
B | 0016787 | molecular_function | hydrolase activity |
B | 0016853 | molecular_function | isomerase activity |
B | 0016868 | molecular_function | intramolecular phosphotransferase activity |
B | 0033554 | biological_process | cellular response to stress |
B | 0042832 | biological_process | defense response to protozoan |
B | 0046538 | molecular_function | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity |
B | 0048821 | biological_process | erythrocyte development |
B | 0060856 | biological_process | establishment of blood-brain barrier |
B | 0070062 | cellular_component | extracellular exosome |
B | 0150076 | biological_process | neuroinflammatory response |
B | 1901136 | biological_process | carbohydrate derivative catabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE HAI A 2000 |
Chain | Residue |
A | LEU95 |
A | HIS107 |
A | PRO124 |
site_id | AC2 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE DG2 B 2200 |
Chain | Residue |
B | ARG62 |
B | GLU89 |
B | TYR92 |
B | ARG100 |
B | ARG116 |
B | ARG117 |
B | HIS188 |
B | GLY189 |
B | ASN190 |
B | HOH3212 |
B | HOH3345 |
B | HOH3422 |
B | HOH3423 |
B | ARG10 |
B | NEP11 |
B | ASN17 |
B | PHE22 |
B | CYS23 |
B | SER24 |
site_id | AC3 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE DG2 A 2201 |
Chain | Residue |
A | ARG10 |
A | NEP11 |
A | ASN17 |
A | PHE22 |
A | CYS23 |
A | SER24 |
A | ARG62 |
A | GLU89 |
A | TYR92 |
A | ARG100 |
A | ARG116 |
A | ARG117 |
A | HIS188 |
A | GLY189 |
A | ASN190 |
A | HOH3236 |
A | HOH3238 |
A | HOH3465 |
A | HOH3466 |
site_id | AC4 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 3PG A 3200 |
Chain | Residue |
A | ARG10 |
A | NEP11 |
A | PHE22 |
A | CYS23 |
A | SER24 |
A | GLU89 |
A | TYR92 |
A | ARG100 |
A | ARG116 |
A | ARG117 |
A | ASN190 |
A | HOH3236 |
A | HOH3238 |
A | HOH3465 |
A | HOH3466 |
site_id | AC5 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 3PG B 3201 |
Chain | Residue |
B | ARG10 |
B | NEP11 |
B | PHE22 |
B | CYS23 |
B | SER24 |
B | GLU89 |
B | TYR92 |
B | ARG100 |
B | ARG116 |
B | ARG117 |
B | ASN190 |
B | HOH3212 |
B | HOH3345 |
B | HOH3422 |
B | HOH3423 |
Functional Information from PROSITE/UniProt
site_id | PS00175 |
Number of Residues | 10 |
Details | PG_MUTASE Phosphoglycerate mutase family phosphohistidine signature. MlRHGEgAwN |
Chain | Residue | Details |
A | MET8-ASN17 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Tele-phosphohistidine intermediate => ECO:0000269|PubMed:17052986 |
Chain | Residue | Details |
A | NEP11 | |
B | NEP11 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:17052986 |
Chain | Residue | Details |
A | GLU89 | |
B | GLU89 |
site_id | SWS_FT_FI3 |
Number of Residues | 14 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17052986 |
Chain | Residue | Details |
A | ARG10 | |
B | ARG62 | |
B | GLU89 | |
B | ARG100 | |
B | ARG116 | |
B | GLY189 | |
A | CYS23 | |
A | ARG62 | |
A | GLU89 | |
A | ARG100 | |
A | ARG116 | |
A | GLY189 | |
B | ARG10 | |
B | CYS23 |
site_id | SWS_FT_FI4 |
Number of Residues | 16 |
Details | SITE: Not glycated => ECO:0000269|PubMed:9832630 |
Chain | Residue | Details |
A | LYS29 | |
B | LYS46 | |
B | LYS143 | |
B | LYS181 | |
B | LYS246 | |
B | LYS247 | |
B | LYS253 | |
B | LYS258 | |
A | LYS46 | |
A | LYS143 | |
A | LYS181 | |
A | LYS246 | |
A | LYS247 | |
A | LYS253 | |
A | LYS258 | |
B | LYS29 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | SITE: Transition state stabilizer => ECO:0000269|PubMed:17052986 |
Chain | Residue | Details |
A | HIS188 | |
B | HIS188 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378 |
Chain | Residue | Details |
A | SER2 | |
B | SER2 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | THR122 | |
B | THR122 |
site_id | SWS_FT_FI8 |
Number of Residues | 10 |
Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:9832630 |
Chain | Residue | Details |
A | LYS3 | |
B | LYS197 | |
A | LYS5 | |
A | LYS18 | |
A | LYS43 | |
A | LYS197 | |
B | LYS3 | |
B | LYS5 | |
B | LYS18 | |
B | LYS43 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:9832630 |
Chain | Residue | Details |
A | LYS159 | |
B | LYS159 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1qhf |
Chain | Residue | Details |
A | ARG62 | |
A | HIS188 | |
A | GLU89 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1qhf |
Chain | Residue | Details |
B | ARG62 | |
B | HIS188 | |
B | GLU89 |