2HG5

Cs+ complex of a K channel with an amide to ester substitution in the selectivity filter

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0002250	biological_process	adaptive immune response
B	0005576	cellular_component	extracellular region
B	0005886	cellular_component	plasma membrane
B	0030183	biological_process	B cell differentiation
B	0042105	cellular_component	alpha-beta T cell receptor complex
B	0071735	cellular_component	IgG immunoglobulin complex
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0006813	biological_process	potassium ion transport
C	0008076	cellular_component	voltage-gated potassium channel complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CS C 201

Chain	Residue
C	THR75
C	THR75
C	THR75
C	THR75
C	VAL76
C	VAL76
C	VAL76
C	VAL76

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CS C 202

Chain	Residue
C	GLY77
C	GLY77
C	GLY77
C	GLY77

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CS C 203

Chain	Residue
C	THR75
C	THR75
C	THR75
C	THR75

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOA C 79

Chain	Residue
C	GLY77
C	TYR78
C	TYR78
C	ASP80
C	LEU81
C	TYR82

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE B3H C 205

Chain	Residue
C	PRO63
C	LEU66
C	ARG89
C	LEU90

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
B	TYR192-HIS198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	97
Details	Domain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	45
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Topological domain: {"description":"Extracellular"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Intramembrane: {"description":"Helical; Pore-forming"}

Chain

Residue

Details

---