2HEN

Crystal Structure of the EphB2 Receptor Kinase domain in complex with ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 404

Chain	Residue
A	HOH61
A	ADP400
A	ASN759

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 405

Chain	Residue
B	ADP401
B	ARG758
B	ASN759
B	ASP772

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG C 406

Chain	Residue
C	ADP402
C	ASN759

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 407

Chain	Residue
D	ADP403
D	ARG758
D	ASN759
D	ASP772

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP A 400

Chain	Residue
A	HOH61
A	HOH126
A	HOH151
A	HOH292
A	MG404
A	ILE635
A	ALA637
A	GLU639
A	ALA659
A	LYS661
A	THR707
A	GLU708
A	MET710
A	SER714

---

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP B 401

Chain	Residue
B	HOH44
B	HOH62
B	HOH171
B	MG405
B	ILE635
B	ALA637
B	GLU639
B	VAL643
B	ALA659
B	LYS661
B	THR707
B	GLU708
B	MET710
B	SER714
B	LEU761
B	ASP772

---

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP C 402

Chain	Residue
C	HOH90
C	HOH239
C	MG406
C	ILE635
C	ALA637
C	GLU639
C	ALA659
C	LYS661
C	THR707
C	GLU708
C	MET710
C	SER714

---

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADP D 403

Chain	Residue
D	HOH6
D	MG407
D	ILE635
D	ALA637
D	GLU639
D	VAL643
D	ALA659
D	LYS661
D	THR707
D	GLU708
D	PHE709
D	MET710
D	SER714
D	LEU761
D	ASP772

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	27
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGAGEFGEVCsGhlklpgkreif.......VAIK

Chain	Residue	Details
A	ILE635-LYS661

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ALA746
B	ALA746
C	ALA746
D	ALA746

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	SER627
A	LYS653
B	SER627
B	LYS653
C	SER627
C	LYS653
D	SER627
D	LYS653

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P29323

Chain	Residue	Details
A	MET891
B	MET891
C	MET891
D	MET891

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ALA754
A	ARG758

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ALA754
B	ARG758

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site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ALA754
C	ARG758

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site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ALA754
D	ARG758

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