2HE3

Crystal structure of the selenocysteine to cysteine mutant of human glutathionine peroxidase 2 (GPX2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0009055	molecular_function	electron transfer activity
A	0016491	molecular_function	oxidoreductase activity
A	0045171	cellular_component	intercellular bridge
A	0047066	molecular_function	phospholipid-hydroperoxide glutathione peroxidase activity
A	0072686	cellular_component	mitotic spindle
A	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 189

Chain	Residue
A	PHE57
A	PRO58
A	ARG59
A	ARG60

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 190

Chain	Residue
A	GLY160
A	GLU162
A	GLY163
A	GLU164

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Functional Information from PROSITE/UniProt

site_id	PS00460
Number of Residues	16
Details	GLUTATHIONE_PEROXID_1 Glutathione peroxidases active site. GRaVLIeNVaSlCGtT

Chain	Residue	Details
A	GLY28-THR43

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site_id	PS00763
Number of Residues	8
Details	GLUTATHIONE_PEROXID_2 Glutathione peroxidases signature 2. LGFPCNQF

Chain	Residue	Details
A	LEU64-PHE71

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"O70325","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Non-standard residue: {"description":"Selenocysteine","evidences":[{"source":"UniProtKB","id":"O70325","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1gp1

Chain	Residue	Details
A	TRP152
A	GLN74

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