Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2HDN

Trypsin-modified Elongation Factor Tu in complex with tetracycline at 2.8 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
B	0003746	molecular_function	translation elongation factor activity
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0006414	biological_process	translational elongation
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
D	0003746	molecular_function	translation elongation factor activity
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
D	0006414	biological_process	translational elongation
E	0003924	molecular_function	GTPase activity
E	0005525	molecular_function	GTP binding
F	0003746	molecular_function	translation elongation factor activity
F	0003924	molecular_function	GTPase activity
F	0005525	molecular_function	GTP binding
F	0006414	biological_process	translational elongation
G	0003924	molecular_function	GTPase activity
G	0005525	molecular_function	GTP binding
H	0003746	molecular_function	translation elongation factor activity
H	0003924	molecular_function	GTPase activity
H	0005525	molecular_function	GTP binding
H	0006414	biological_process	translational elongation
I	0003924	molecular_function	GTPase activity
I	0005525	molecular_function	GTP binding
J	0003746	molecular_function	translation elongation factor activity
J	0003924	molecular_function	GTPase activity
J	0005525	molecular_function	GTP binding
J	0006414	biological_process	translational elongation
K	0003924	molecular_function	GTPase activity
K	0005525	molecular_function	GTP binding
L	0003746	molecular_function	translation elongation factor activity
L	0003924	molecular_function	GTPase activity
L	0005525	molecular_function	GTP binding
L	0006414	biological_process	translational elongation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1998

Chain	Residue
A	THR25
B	HOH1001
B	HOH1002
B	TAC1888
B	GDP1999

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 2998

Chain	Residue
D	GDP2999
C	THR25
D	HOH2001
D	HOH2002
D	TAC2888

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG E 3998

Chain	Residue
E	THR25
F	HOH3001
F	HOH3002
F	TAC3888
F	GDP3999

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG G 4998

Chain	Residue
G	THR25
H	CYS81
H	HOH4001
H	HOH4002
H	TAC4888
H	GDP4999

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG I 5998

Chain	Residue
I	THR25
J	HOH5001
J	HOH5002
J	TAC5888
J	GDP5999

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG K 6998

Chain	Residue
K	THR25
L	HOH6001
L	HOH6002
L	TAC6888
L	GDP6999

site_id	AC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GDP B 1999

Chain	Residue
A	ASP21
A	HIS22
A	GLY23
A	LYS24
A	THR25
A	THR26
A	MG1998
B	ASN135
B	LYS136
B	ASP138
B	MET139
B	SER173
B	ALA174
B	LEU175
B	HOH1002
B	TAC1888

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TAC B 1888

Chain	Residue
A	THR25
A	MG1998
B	THR64
B	SER65
B	ASP80
B	CYS81
B	PRO82
B	HOH1001
B	HOH1002
B	HOH1003
B	GDP1999
D	TAC2888

site_id	AC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GDP D 2999

Chain	Residue
C	ASP21
C	HIS22
C	GLY23
C	LYS24
C	THR25
C	THR26
C	MG2998
D	ASN135
D	LYS136
D	ASP138
D	MET139
D	SER173
D	ALA174
D	LEU175
D	HOH2002
D	TAC2888

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TAC D 2888

Chain	Residue
B	TAC1888
C	THR25
C	HOH2003
C	MG2998
D	THR64
D	SER65
D	ASP80
D	CYS81
D	PRO82
D	HOH2001
D	GDP2999

site_id	BC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GDP F 3999

Chain	Residue
F	LEU175
F	HOH3002
F	HOH3114
F	TAC3888
E	ASP21
E	HIS22
E	GLY23
E	LYS24
E	THR25
E	THR26
E	MG3998
F	ASN135
F	LYS136
F	ASP138
F	MET139
F	SER173
F	ALA174

site_id	BC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TAC F 3888

Chain	Residue
E	THR25
E	MG3998
F	THR64
F	SER65
F	ASP80
F	CYS81
F	PRO82
F	HOH3001
F	HOH3003
F	GDP3999
H	VAL67
H	TAC4888

site_id	BC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GDP H 4999

Chain	Residue
G	ASP21
G	HIS22
G	GLY23
G	LYS24
G	THR25
G	THR26
G	MG4998
H	ASN135
H	LYS136
H	ASP138
H	MET139
H	SER173
H	ALA174
H	LEU175
H	HOH4002
H	HOH4115
H	TAC4888

site_id	BC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE TAC H 4888

Chain	Residue
F	VAL67
F	LEU178
F	TAC3888
G	THR25
G	MG4998
H	THR64
H	SER65
H	ASP80
H	CYS81
H	PRO82
H	HOH4001
H	HOH4003
H	HOH4115
H	GDP4999

site_id	BC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GDP J 5999

Chain	Residue
I	ASP21
I	HIS22
I	GLY23
I	LYS24
I	THR25
I	THR26
I	MG5998
J	ASN135
J	LYS136
J	ASP138
J	MET139
J	SER173
J	ALA174
J	LEU175
J	HOH5002
J	TAC5888

site_id	BC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TAC J 5888

Chain	Residue
I	THR25
I	MG5998
J	THR64
J	SER65
J	ASP80
J	CYS81
J	PRO82
J	HOH5001
J	HOH5002
J	HOH5003
J	GDP5999
L	TAC6888

site_id	BC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GDP L 6999

Chain	Residue
K	ASP21
K	HIS22
K	GLY23
K	LYS24
K	THR25
K	THR26
K	MG6998
L	ASN135
L	LYS136
L	ASP138
L	MET139
L	SER173
L	ALA174
L	LEU175
L	HOH6002
L	TAC6888

site_id	BC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TAC L 6888

Chain	Residue
J	VAL67
J	TAC5888
K	THR25
K	MG6998
L	THR64
L	SER65
L	ASP80
L	CYS81
L	PRO82
L	HOH6001
L	HOH6003
L	GDP6999

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Region: {"description":"G1","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	84
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29546243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5MI3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OPD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	30
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"21151122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	54
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29546243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5OPD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	24
Details	Region: {"description":"G2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	18
Details	Region: {"description":"G3","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	18
Details	Region: {"description":"G4","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	12
Details	Region: {"description":"G5","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19150849","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24141193","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8416965","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	ASP21

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
H	HIS84

site_id	CSA11
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
J	HIS84

site_id	CSA12
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
L	HIS84

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	ASP21

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
E	ASP21

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
G	ASP21

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
I	ASP21

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
K	ASP21

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	HIS84

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
D	HIS84

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
F	HIS84

site_id	MCSA1
Number of Residues	1
Details	M-CSA 535

Chain	Residue	Details
B	HIS84	electrostatic stabiliser
A	LYS24	electrostatic stabiliser
A	THR25	metal ligand

site_id	MCSA2
Number of Residues	1
Details	M-CSA 535

Chain	Residue	Details
D	HIS84	electrostatic stabiliser
C	LYS24	electrostatic stabiliser
C	THR25	metal ligand

site_id	MCSA3
Number of Residues	1
Details	M-CSA 535

Chain	Residue	Details
F	HIS84	electrostatic stabiliser
E	LYS24	electrostatic stabiliser
E	THR25	metal ligand

site_id	MCSA4
Number of Residues	1
Details	M-CSA 535

Chain	Residue	Details
H	HIS84	electrostatic stabiliser
G	LYS24	electrostatic stabiliser
G	THR25	metal ligand

site_id	MCSA5
Number of Residues	1
Details	M-CSA 535

Chain	Residue	Details
J	HIS84	electrostatic stabiliser
I	LYS24	electrostatic stabiliser
I	THR25	metal ligand

site_id	MCSA6
Number of Residues	1
Details	M-CSA 535

Chain	Residue	Details
L	HIS84	electrostatic stabiliser
K	LYS24	electrostatic stabiliser
K	THR25	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)