2HD0
Structure of the catalytic domain of hepatitis C virus NS2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| C | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| D | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| E | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| F | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| G | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| H | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| I | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| J | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| K | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| L | 0004197 | molecular_function | cysteine-type endopeptidase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | ACT_SITE: For protease NS2 activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU01030, ECO:0000269|PubMed:16862121, ECO:0000269|PubMed:8248148 |
| Chain | Residue | Details |
| A | HIS143 | |
| E | CYS184 | |
| F | HIS143 | |
| F | CYS184 | |
| G | HIS143 | |
| G | CYS184 | |
| H | HIS143 | |
| H | CYS184 | |
| I | HIS143 | |
| I | CYS184 | |
| J | HIS143 | |
| A | CYS184 | |
| J | CYS184 | |
| K | HIS143 | |
| K | CYS184 | |
| L | HIS143 | |
| L | CYS184 | |
| B | HIS143 | |
| B | CYS184 | |
| C | HIS143 | |
| C | CYS184 | |
| D | HIS143 | |
| D | CYS184 | |
| E | HIS143 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | ACT_SITE: For protease NS2 activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU01030 |
| Chain | Residue | Details |
| A | GLU163 | |
| J | GLU163 | |
| K | GLU163 | |
| L | GLU163 | |
| B | GLU163 | |
| C | GLU163 | |
| D | GLU163 | |
| E | GLU163 | |
| F | GLU163 | |
| G | GLU163 | |
| H | GLU163 | |
| I | GLU163 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | SITE: Cleavage; by protease NS2 => ECO:0000255|PROSITE-ProRule:PRU01030 |
| Chain | Residue | Details |
| A | LEU217 | |
| J | LEU217 | |
| K | LEU217 | |
| L | LEU217 | |
| B | LEU217 | |
| C | LEU217 | |
| D | LEU217 | |
| E | LEU217 | |
| F | LEU217 | |
| G | LEU217 | |
| H | LEU217 | |
| I | LEU217 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | LIPID: S-palmitoyl cysteine; by host => ECO:0000269|PubMed:31597774 |
| Chain | Residue | Details |
| A | CYS113 | |
| J | CYS113 | |
| K | CYS113 | |
| L | CYS113 | |
| B | CYS113 | |
| C | CYS113 | |
| D | CYS113 | |
| E | CYS113 | |
| F | CYS113 | |
| G | CYS113 | |
| H | CYS113 | |
| I | CYS113 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | |
| Details | M-CSA 776 |
| Chain | Residue | Details |
| site_id | MCSA10 |
| Number of Residues | |
| Details | M-CSA 776 |
| Chain | Residue | Details |
| site_id | MCSA11 |
| Number of Residues | |
| Details | M-CSA 776 |
| Chain | Residue | Details |
| site_id | MCSA12 |
| Number of Residues | |
| Details | M-CSA 776 |
| Chain | Residue | Details |
| site_id | MCSA2 |
| Number of Residues | |
| Details | M-CSA 776 |
| Chain | Residue | Details |
| site_id | MCSA3 |
| Number of Residues | |
| Details | M-CSA 776 |
| Chain | Residue | Details |
| site_id | MCSA4 |
| Number of Residues | |
| Details | M-CSA 776 |
| Chain | Residue | Details |
| site_id | MCSA5 |
| Number of Residues | |
| Details | M-CSA 776 |
| Chain | Residue | Details |
| site_id | MCSA6 |
| Number of Residues | |
| Details | M-CSA 776 |
| Chain | Residue | Details |
| site_id | MCSA7 |
| Number of Residues | |
| Details | M-CSA 776 |
| Chain | Residue | Details |
| site_id | MCSA8 |
| Number of Residues | |
| Details | M-CSA 776 |
| Chain | Residue | Details |
| site_id | MCSA9 |
| Number of Residues | |
| Details | M-CSA 776 |
| Chain | Residue | Details |
