2HD0
Structure of the catalytic domain of hepatitis C virus NS2
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
C | 0004197 | molecular_function | cysteine-type endopeptidase activity |
D | 0004197 | molecular_function | cysteine-type endopeptidase activity |
E | 0004197 | molecular_function | cysteine-type endopeptidase activity |
F | 0004197 | molecular_function | cysteine-type endopeptidase activity |
G | 0004197 | molecular_function | cysteine-type endopeptidase activity |
H | 0004197 | molecular_function | cysteine-type endopeptidase activity |
I | 0004197 | molecular_function | cysteine-type endopeptidase activity |
J | 0004197 | molecular_function | cysteine-type endopeptidase activity |
K | 0004197 | molecular_function | cysteine-type endopeptidase activity |
L | 0004197 | molecular_function | cysteine-type endopeptidase activity |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 24 |
Details | ACT_SITE: For protease NS2 activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU01030, ECO:0000269|PubMed:16862121, ECO:0000269|PubMed:8248148 |
Chain | Residue | Details |
A | HIS143 | |
E | CYS184 | |
F | HIS143 | |
F | CYS184 | |
G | HIS143 | |
G | CYS184 | |
H | HIS143 | |
H | CYS184 | |
I | HIS143 | |
I | CYS184 | |
J | HIS143 | |
A | CYS184 | |
J | CYS184 | |
K | HIS143 | |
K | CYS184 | |
L | HIS143 | |
L | CYS184 | |
B | HIS143 | |
B | CYS184 | |
C | HIS143 | |
C | CYS184 | |
D | HIS143 | |
D | CYS184 | |
E | HIS143 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | ACT_SITE: For protease NS2 activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU01030 |
Chain | Residue | Details |
A | GLU163 | |
J | GLU163 | |
K | GLU163 | |
L | GLU163 | |
B | GLU163 | |
C | GLU163 | |
D | GLU163 | |
E | GLU163 | |
F | GLU163 | |
G | GLU163 | |
H | GLU163 | |
I | GLU163 |
site_id | SWS_FT_FI3 |
Number of Residues | 12 |
Details | SITE: Cleavage; by protease NS2 => ECO:0000255|PROSITE-ProRule:PRU01030 |
Chain | Residue | Details |
A | LEU217 | |
J | LEU217 | |
K | LEU217 | |
L | LEU217 | |
B | LEU217 | |
C | LEU217 | |
D | LEU217 | |
E | LEU217 | |
F | LEU217 | |
G | LEU217 | |
H | LEU217 | |
I | LEU217 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | LIPID: S-palmitoyl cysteine; by host => ECO:0000269|PubMed:31597774 |
Chain | Residue | Details |
A | CYS113 | |
J | CYS113 | |
K | CYS113 | |
L | CYS113 | |
B | CYS113 | |
C | CYS113 | |
D | CYS113 | |
E | CYS113 | |
F | CYS113 | |
G | CYS113 | |
H | CYS113 | |
I | CYS113 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | |
Details | M-CSA 776 |
Chain | Residue | Details |
site_id | MCSA10 |
Number of Residues | |
Details | M-CSA 776 |
Chain | Residue | Details |
site_id | MCSA11 |
Number of Residues | |
Details | M-CSA 776 |
Chain | Residue | Details |
site_id | MCSA12 |
Number of Residues | |
Details | M-CSA 776 |
Chain | Residue | Details |
site_id | MCSA2 |
Number of Residues | |
Details | M-CSA 776 |
Chain | Residue | Details |
site_id | MCSA3 |
Number of Residues | |
Details | M-CSA 776 |
Chain | Residue | Details |
site_id | MCSA4 |
Number of Residues | |
Details | M-CSA 776 |
Chain | Residue | Details |
site_id | MCSA5 |
Number of Residues | |
Details | M-CSA 776 |
Chain | Residue | Details |
site_id | MCSA6 |
Number of Residues | |
Details | M-CSA 776 |
Chain | Residue | Details |
site_id | MCSA7 |
Number of Residues | |
Details | M-CSA 776 |
Chain | Residue | Details |
site_id | MCSA8 |
Number of Residues | |
Details | M-CSA 776 |
Chain | Residue | Details |
site_id | MCSA9 |
Number of Residues | |
Details | M-CSA 776 |
Chain | Residue | Details |