Functional Information from GO Data
Chain | GOid | namespace | contents |
C | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
C | 0005576 | cellular_component | extracellular region |
C | 0010466 | biological_process | negative regulation of peptidase activity |
H | 0004252 | molecular_function | serine-type endopeptidase activity |
H | 0006508 | biological_process | proteolysis |
L | 0005509 | molecular_function | calcium ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PO4 H 601 |
Chain | Residue |
H | TYR184 |
H | ASP185 |
H | THR185 |
H | LYS186 |
H | HOH743 |
L | HOH209 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PO4 H 602 |
Chain | Residue |
H | ARG115 |
H | MET116 |
L | TYR130 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PO4 H 603 |
Chain | Residue |
H | GLY78 |
H | GLY79 |
H | ARG115 |
H | ARG149 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PO4 H 604 |
site_id | AC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PO4 H 605 |
Chain | Residue |
H | ARG125 |
H | LYS236 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PO4 H 606 |
Chain | Residue |
H | GLN187 |
H | ARG222 |
H | LYS223 |
H | HOH797 |
H | HOH861 |
site_id | AC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE ACT H 701 |
Chain | Residue |
H | THR144 |
H | LYS155 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ACT H 702 |
Chain | Residue |
H | ARG202 |
H | LYS204 |
H | ASP205 |
H | HOH745 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ACT H 703 |
Chain | Residue |
H | ARG164 |
H | LYS168 |
H | GLN177 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA H 501 |
Chain | Residue |
H | TYR184 |
H | LYS186 |
H | ARG222 |
H | LYS224 |
H | HOH732 |
site_id | BC2 |
Number of Residues | 24 |
Details | BINDING SITE FOR CHAIN S OF SELECTIDE INHIBITOR DTY-ILE-ARG-LEU-LPD PEPTIDE |
Chain | Residue |
H | HIS57 |
H | GLU97 |
H | THR98 |
H | THR113 |
H | PHE173 |
H | ALA190 |
H | GLN192 |
H | SER195 |
H | VAL213 |
H | SER214 |
H | TRP215 |
H | GLY216 |
H | GLU217 |
H | ARG222 |
H | GLY226 |
H | HOH752 |
H | HOH754 |
H | HOH867 |
S | HOH6 |
S | HOH7 |
S | HOH8 |
S | HOH10 |
S | HOH13 |
S | HOH14 |
Functional Information from PROSITE/UniProt
site_id | PS00010 |
Number of Residues | 12 |
Details | ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CkDglgeYtCtC |
Chain | Residue | Details |
L | CYS61-CYS72 | |
site_id | PS00022 |
Number of Residues | 12 |
Details | EGF_1 EGF-like domain signature 1. CtCleGfeGKnC |
Chain | Residue | Details |
L | CYS70-CYS81 | |
site_id | PS00134 |
Number of Residues | 6 |
Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
Chain | Residue | Details |
H | LEU53-CYS58 | |
site_id | PS00135 |
Number of Residues | 12 |
Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAcqGDSGGPHV |
Chain | Residue | Details |
H | ASP189-VAL200 | |
site_id | PS01186 |
Number of Residues | 15 |
Details | EGF_2 EGF-like domain signature 2. CvCeeGFyrnkddk.C |
Chain | Residue | Details |
C | CYS50-CYS64 | |
L | CYS70-CYS81 | |
L | CYS109-CYS124 | |
site_id | PS01187 |
Number of Residues | 25 |
Details | EGF_CA Calcium-binding EGF-like domain signature. DgDQCetsp..........Cqnqgk..CkDglgeYtC |
Chain | Residue | Details |
L | ASP46-CYS70 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
L | ASP63 | |
H | ASP102 | |
H | SER195 | |
Chain | Residue | Details |
L | THR159 | |
L | THR171 | |
Chain | Residue | Details |
L | ASN181 | |
L | ASN191 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
H | ASP102 | |
H | HIS57 | |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
H | SER195 | |
H | GLY196 | |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
H | SER195 | |
H | GLY193 | |
site_id | CSA4 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
H | ASP102 | |
H | SER195 | |
H | HIS57 | |
site_id | CSA5 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
H | SER195 | |
H | ASP100 | |
H | GLY193 | |
H | HIS57 | |
site_id | CSA6 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
H | ASP102 | |
H | SER195 | |
H | HIS57 | |
H | GLY196 | |
site_id | CSA7 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
H | ASP102 | |
H | SER195 | |
H | GLY193 | |
H | HIS57 | |