Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| H | 0004252 | molecular_function | serine-type endopeptidase activity |
| H | 0006508 | biological_process | proteolysis |
| L | 0005509 | molecular_function | calcium ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 H 601 |
| Chain | Residue |
| H | TYR184 |
| H | ASP185 |
| H | THR185 |
| H | LYS186 |
| H | HOH743 |
| L | HOH209 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 H 602 |
| Chain | Residue |
| H | ARG115 |
| H | MET116 |
| L | TYR130 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 H 603 |
| Chain | Residue |
| H | GLY78 |
| H | GLY79 |
| H | ARG115 |
| H | ARG149 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PO4 H 604 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PO4 H 605 |
| Chain | Residue |
| H | ARG125 |
| H | LYS236 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 H 606 |
| Chain | Residue |
| H | GLN187 |
| H | ARG222 |
| H | LYS223 |
| H | HOH797 |
| H | HOH861 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT H 701 |
| Chain | Residue |
| H | THR144 |
| H | LYS155 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT H 702 |
| Chain | Residue |
| H | ARG202 |
| H | LYS204 |
| H | ASP205 |
| H | HOH745 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT H 703 |
| Chain | Residue |
| H | ARG164 |
| H | LYS168 |
| H | GLN177 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA H 501 |
| Chain | Residue |
| H | TYR184 |
| H | LYS186 |
| H | ARG222 |
| H | LYS224 |
| H | HOH732 |
| site_id | BC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR CHAIN S OF SELECTIDE INHIBITOR DTY-ILE-ARG-LEU-LPD PEPTIDE |
| Chain | Residue |
| H | HIS57 |
| H | GLU97 |
| H | THR98 |
| H | THR113 |
| H | PHE173 |
| H | ALA190 |
| H | GLN192 |
| H | SER195 |
| H | VAL213 |
| H | SER214 |
| H | TRP215 |
| H | GLY216 |
| H | GLU217 |
| H | ARG222 |
| H | GLY226 |
| H | HOH752 |
| H | HOH754 |
| H | HOH867 |
| S | HOH6 |
| S | HOH7 |
| S | HOH8 |
| S | HOH10 |
| S | HOH13 |
| S | HOH14 |
Functional Information from PROSITE/UniProt
| site_id | PS00010 |
| Number of Residues | 12 |
| Details | ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CkDglgeYtCtC |
| Chain | Residue | Details |
| L | CYS61-CYS72 | |
| site_id | PS00022 |
| Number of Residues | 12 |
| Details | EGF_1 EGF-like domain signature 1. CtCleGfeGKnC |
| Chain | Residue | Details |
| L | CYS70-CYS81 | |
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| H | LEU53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAcqGDSGGPHV |
| Chain | Residue | Details |
| H | ASP189-VAL200 | |
| site_id | PS01186 |
| Number of Residues | 15 |
| Details | EGF_2 EGF-like domain signature 2. CvCeeGFyrnkddk.C |
| Chain | Residue | Details |
| C | CYS50-CYS64 | |
| L | CYS70-CYS81 | |
| L | CYS109-CYS124 | |
| site_id | PS01187 |
| Number of Residues | 25 |
| Details | EGF_CA Calcium-binding EGF-like domain signature. DgDQCetsp..........Cqnqgk..CkDglgeYtC |
| Chain | Residue | Details |
| L | ASP46-CYS70 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 232 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system"} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | ASP102 | |
| H | HIS57 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | SER195 | |
| H | GLY196 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | SER195 | |
| H | GLY193 | |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | ASP102 | |
| H | SER195 | |
| H | HIS57 | |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | SER195 | |
| H | ASP100 | |
| H | GLY193 | |
| H | HIS57 | |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | ASP102 | |
| H | SER195 | |
| H | HIS57 | |
| H | GLY196 | |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | ASP102 | |
| H | SER195 | |
| H | GLY193 | |
| H | HIS57 | |
